Detailed information for compound 1873698

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 325.34 | Formula: C13H15N3O5S
  • H donors: 5 H acceptors: 6 LogP: 0.31 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OS(=O)(=O)O.Nc1ccc2c(c1)nc1c(c2)ccc(c1)N.O
  • InChi: 1S/C13H11N3.H2O4S.H2O/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h1-7H,14-15H2;(H2,1,2,3,4);1H2
  • InChiKey: MSAVMVWXUVKHBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuroligin 0.0486 0.1641 0.1641
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0053 0.0053
Echinococcus multilocularis small conductance calcium activated potassium 0.0121 0.0364 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0053 0.0053
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0748 0.2559 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.007 0.0198
Trichomonas vaginalis mismatch repair protein Pms1 (mutL homolog) 0.0023 0.0022 0.0038
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0292 0.0966 0.0965
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0032 0.0032
Mycobacterium ulcerans two component sensor kinase MprB 0.0152 0.0474 0.1209
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0028 0.0057
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0152 0.0474 0.1209
Trichomonas vaginalis heat shock protein, putative 0.0538 0.1824 0.6045
Onchocerca volvulus 0.0028 0.0039 0.0214
Brugia malayi kinase, mitochondrial precursor 0.0152 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0094 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.0708 0.2419 0.2418
Plasmodium vivax heat shock protein 90, putative 0.0498 0.1684 0.556
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0152 0.0474 0.0473
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0062 0.0133
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0022
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis epidermal growth factor receptor 0.0154 0.0481 0.048
Leishmania major DNA topoisomerase ii 0.0152 0.0474 0.1511
Brugia malayi Uncoordinated protein 44 0.0017 0.0003 0.0003
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.001
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.007 0.0205
Schistosoma mansoni hypothetical protein 0.0121 0.0364 0.0364
Brugia malayi aspartic protease BmAsp-2, identical 0.006 0.0151 0.0151
Onchocerca volvulus 0.0028 0.0039 0.0214
Schistosoma mansoni heat shock protein 0.0877 0.3011 0.301
Loa Loa (eye worm) hypothetical protein 0.006 0.0151 0.0151
Onchocerca volvulus 0.0031 0.0049 0.0276
Loa Loa (eye worm) hypothetical protein 0.2874 1 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0103 0.0271
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0152 0.0474 0.0473
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0011 0.0011
Echinococcus granulosus BC026374 protein S09 family 0.0486 0.1641 0.1641
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0011 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0053 0.0052
Schistosoma mansoni aryl hydrocarbon receptor 0.0094 0.0273 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0103 0.0103
Mycobacterium ulcerans heat shock protein 90 0.0748 0.2559 1
Plasmodium falciparum plasmepsin II 0.006 0.0151 0.0432
Brugia malayi Protein kinase domain containing protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) TK/INSR protein kinase 0.005 0.0117 0.0116
Brugia malayi intermediate filament protein 0.0028 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.005 0.0131
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0033 0.0021
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0083 0.0233 0.0233
Schistosoma mansoni survival motor neuron protein 0.0049 0.0115 0.0114
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0152 0.0474 0.178
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.001
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0049 0.0048
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0011 0.001
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.0117 0.0116
Schistosoma mansoni lamin 0.0028 0.0039 0.0038
Entamoeba histolytica DNA mismatch repair protein PMS1, putative 0.0023 0.0022 0.0038
Trypanosoma cruzi heat shock protein 85, putative 0.0877 0.3011 1
Toxoplasma gondii aspartyl protease ASP3 0.006 0.0151 0.0432
Trichomonas vaginalis heat shock protein, putative 0.0877 0.3011 1
Plasmodium falciparum plasmepsin III 0.006 0.0151 0.0432
Entamoeba histolytica DNA mismatch repair protein MLH1, putative 0.0023 0.0022 0.0038
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0748 0.2559 1
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi hypothetical protein 0.006 0.0151 0.0151
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0103 0.0103
Entamoeba histolytica hypothetical protein 0.0043 0.0094 0.0278
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0003 0.0003
Brugia malayi aspartic protease BmAsp-1, identical 0.006 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0049 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0028 0.0057
Schistosoma mansoni tyrosine kinase 0.005 0.0117 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0049 0.0048
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0638 0.2174 0.2174
Schistosoma mansoni pyruvate dehydrogenase 0.0152 0.0474 0.0473
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0053 0.0052
Echinococcus multilocularis acetylcholinesterase 0.2874 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0179 0.0179
Brugia malayi hypothetical protein 0.006 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0038
Brugia malayi hypothetical protein 0.002 0.0011 0.0011
Brugia malayi hypothetical protein 0.0486 0.1641 0.1641
Brugia malayi nuclear hormone receptor 0.0032 0.0053 0.0053
Brugia malayi Pepsin A precursor 0.006 0.0151 0.0151
Plasmodium falciparum plasmepsin IX 0.006 0.0151 0.0432
Trypanosoma brucei heat shock protein 90, putative 0.0877 0.3011 1
Schistosoma mansoni tyrosine kinase 0.0081 0.0227 0.0226
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0152 0.0474 0.178
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0033 0.0037
Trypanosoma cruzi Heat shock protein 83, putative 0.0877 0.3011 1
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.0791 0.079
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0028 0.0027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0206
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0152 0.0474 0.1209
Loa Loa (eye worm) heat shock protein 75 0.0498 0.1684 0.1683
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0486 0.1641 0.1641
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0053 0.0052
Echinococcus multilocularis lamin dm0 0.0028 0.0039 0.0038
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0152 0.0474 0.178
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0011 0.001
Giardia lamblia Heat shock protein HSP 90-alpha 0.0877 0.3011 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0052 0.0051
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0152 0.0474 0.1548
Onchocerca volvulus 0.006 0.0151 0.0884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0053 0.0052
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0053 0.0053
Plasmodium falciparum plasmepsin VII 0.006 0.0151 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0053 0.0053
Echinococcus multilocularis endoplasmin 0.0748 0.2559 0.2559
Schistosoma mansoni microtubule-associated protein tau 0.0708 0.2419 0.2418
Brugia malayi PAS domain containing protein 0.0094 0.0273 0.0273
Plasmodium falciparum plasmepsin I 0.006 0.0151 0.0432
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0011 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0053 0.0299
Schistosoma mansoni Microrchidia 2a 0.0023 0.0022 0.0022
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Echinococcus multilocularis geminin 0.0346 0.1154 0.1154
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0092
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.0117 0.0116
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Loa Loa (eye worm) carboxylesterase 0.0486 0.1641 0.1641
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0028 0.0057
Trichomonas vaginalis receptor histidine kinase, putative 0.0152 0.0474 0.1543
Echinococcus granulosus endoplasmin 0.0748 0.2559 0.2559
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0053 0.0052
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0011 0.001
Trichomonas vaginalis endoplasmin, putative 0.0538 0.1824 0.6045
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0103 0.0308
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0028 0.0027
Plasmodium falciparum plasmepsin VIII, putative 0.006 0.0151 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.007 0.0198
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0049 0.0048
Loa Loa (eye worm) acetylcholinesterase 1 0.2874 1 1
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0152 0.0474 0.178
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Trichomonas vaginalis mismatch repair protein Mlh3 (mutL homolog) 0.0023 0.0022 0.0038
Echinococcus granulosus para nitrobenzyl esterase 0.0486 0.1641 0.1641
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0002
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0152 0.0474 0.1511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0092
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0152 0.0474 0.1466
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0011 0.0011
Echinococcus granulosus intermediate filament protein 0.0028 0.0039 0.0038
Plasmodium vivax aspartyl protease, putative 0.006 0.0151 0.0432
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0051
Trichomonas vaginalis sensor histidine kinase, putative 0.0152 0.0474 0.1543
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0207 0.0706
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0011 0.001
Onchocerca volvulus 0.0049 0.0115 0.0668
Trichomonas vaginalis heat shock protein, putative 0.0725 0.2479 0.8228
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0152 0.0474 0.1548
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0022
Plasmodium falciparum plasmepsin VI 0.006 0.0151 0.0432
Brugia malayi PXA domain containing protein 0.002 0.0011 0.0011
Schistosoma mansoni tyrosine kinase 0.0083 0.0233 0.0233
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0289 0.0289
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Schistosoma mansoni coup transcription factor 0.0032 0.0053 0.0052
Brugia malayi steroid hormone receptor 0.0032 0.0053 0.0053
Plasmodium falciparum DNA gyrase subunit B 0.0152 0.0474 0.1511
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0103 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0152 0.0474 0.1209
Echinococcus multilocularis para nitrobenzyl esterase 0.0486 0.1641 0.1641
Trypanosoma cruzi heat shock protein 85, putative 0.0725 0.2479 0.8221
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0052 0.0052
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.006 0.0151 0.0469
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0011 0.001
Giardia lamblia Grp94/Hsp90 0.0748 0.2559 0.8489
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0207 0.0617
Trypanosoma brucei Heat shock protein 83, putative 0.0877 0.3011 1
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0053 0.0052
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0152 0.0474 0.0473
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.0114
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.3434
Echinococcus granulosus single minded 2 0.007 0.0187 0.0186
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Onchocerca volvulus 0.0486 0.1641 0.9748
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0028 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.007 0.0198
Loa Loa (eye worm) hypothetical protein 0.0026 0.0032 0.0031
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0152 0.0474 0.1548
Giardia lamblia Fructose-bisphosphate aldolase 0.0582 0.1979 0.6549
Trypanosoma cruzi DNA topoisomerase II, putative 0.0152 0.0474 0.1511
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.006 0.0151 0.0432
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Echinococcus multilocularis heat shock protein 0.0877 0.3011 0.301
Trypanosoma brucei DNA topoisomerase ii 0.0152 0.0474 0.1548
Giardia lamblia Heat shock protein HSP 90-alpha 0.0725 0.2479 0.8221
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0011 0.0011
Mycobacterium ulcerans putative regultory protein 0.0152 0.0474 0.1209
Brugia malayi Probable DNA topoisomerase II 0.0152 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Echinococcus granulosus microtubule associated protein 2 0.0708 0.2419 0.2418
Schistosoma mansoni tyrosine kinase 0.0081 0.0227 0.0226
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0103 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0103 0.0308
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0039 0.0038
Brugia malayi Carboxylesterase family protein 0.0486 0.1641 0.1641
Echinococcus granulosus heat shock protein 90 0.0725 0.2479 0.2479
Leishmania major protein kinase, putative 0.0025 0.0028 0.0019
Plasmodium vivax aspartyl protease, putative 0.006 0.0151 0.0432
Plasmodium vivax SET domain protein, putative 0.0031 0.0049 0.009
Brugia malayi Pre-SET motif family protein 0.0213 0.0689 0.0689
Trichomonas vaginalis heat shock protein, putative 0.0748 0.2559 0.8495
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.012
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0028 0.0057
Loa Loa (eye worm) hypothetical protein 0.0152 0.0474 0.0473
Schistosoma mansoni endoplasmin 0.0877 0.3011 0.301
Brugia malayi hypothetical protein 0.002 0.0011 0.0011
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0011 0.0011
Plasmodium vivax aspartyl proteinase, putative 0.006 0.0151 0.0432
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0011 0.001
Trypanosoma brucei developmentally regulated phosphoprotein 0.0152 0.0474 0.1548
Trypanosoma cruzi heat shock protein 90, putative 0.0491 0.166 0.5481
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Chlamydia trachomatis DNA gyrase subunit B 0.0152 0.0474 0.8401
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0152 0.0474 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0053 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0028 0.0019
Trypanosoma brucei mismatch repair protein MLH1 0.0023 0.0022 0.0044
Brugia malayi Carboxylesterase family protein 0.0486 0.1641 0.1641
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0053 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.006 0.0151 0.0151
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0103 0.0314
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.007 0.0161
Entamoeba histolytica DNA topoisomerase II, putative 0.0152 0.0474 0.1543
Schistosoma mansoni DNA topoisomerase II 0.0152 0.0474 0.0473
Entamoeba histolytica hypothetical protein 0.0043 0.0094 0.0278
Loa Loa (eye worm) hypothetical protein 0.2874 1 1
Leishmania major mitochondrial DNA topoisomerase II 0.0152 0.0474 0.1511
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0028 0.0057
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0028 0.0057
Plasmodium falciparum heat shock protein 90 0.0877 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0409 0.1373 0.454
Schistosoma mansoni hypothetical protein 0.0137 0.0421 0.042
Chlamydia trachomatis DNA gyrase subunit B 0.0152 0.0474 0.8401
Schistosoma mansoni DNA mismatch repair protein MLH1 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0289 0.0289
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0152 0.0474 0.2801
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0003
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0617
Echinococcus granulosus Desert hedgehog protein 0.0188 0.0599 0.0599
Schistosoma mansoni calcium-activated potassium channel 0.0121 0.0364 0.0364
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0037 0.0089
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0084
Mycobacterium tuberculosis Conserved protein 0.0152 0.0474 0.1466
Echinococcus granulosus GPCR family 2 0.0031 0.0052 0.0051
Echinococcus multilocularis transfer RNA-Lys 0.007 0.0187 0.0186
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0152 0.0474 0.1543
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0152 0.0474 0.1209
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0498 0.1684 1
Echinococcus granulosus acetylcholinesterase 0.2874 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0115 0.0115
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0289 0.0288
Trichomonas vaginalis mismatch repair protein Mlh2 (mutL homolog) 0.0023 0.0022 0.0038
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0486 0.1641 0.5436
Trypanosoma brucei mismatch repair protein PMS1, putative 0.0023 0.0022 0.0044
Trypanosoma brucei heat shock protein 84, putative 0.0498 0.1684 0.558
Brugia malayi Endoplasmin precursor 0.0877 0.3011 0.3011
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.008 0.023
Plasmodium vivax aspartyl proteinase, putative 0.006 0.0151 0.0432
Echinococcus multilocularis MORC family CW type zinc finger protein 2B 0.0023 0.0022 0.0022
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0152 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.007 0.0198
Toxoplasma gondii heat shock protein 75, putative 0.0498 0.1684 0.556
Leishmania major hypothetical protein, conserved 0.0026 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.006 0.0151 0.0151
Brugia malayi Hint module family protein 0.0051 0.0121 0.0121
Trichomonas vaginalis heat shock protein, putative 0.0748 0.2559 0.8495
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0018 0.0031
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0486 0.1641 0.6244
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.0791 0.079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0053 0.0052
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0053 0.0052
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0152 0.0474 0.1466
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Schistosoma mansoni hypothetical protein 0.0053 0.0128 0.0127
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0152 0.0474 0.1466
Leishmania major hypothetical protein, conserved 0.0152 0.0474 0.1511
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Trypanosoma cruzi heat shock protein 85, putative 0.0877 0.3011 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.0937 0.3362
Echinococcus granulosus axis inhibition protein axin 0.002 0.0011 0.001
Trypanosoma cruzi heat shock protein, putative 0.0498 0.1684 0.556
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0052 0.0052
Onchocerca volvulus 0.0243 0.0793 0.4699
Echinococcus granulosus small conductance calcium activated potassium 0.0121 0.0364 0.0364
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0052 0.0051
Echinococcus multilocularis insulin receptor 0.005 0.0117 0.0116
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0053 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0346 0.1154 0.1154
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0053 0.0052
Brugia malayi bHLH-PAS transcription factor 0.007 0.0187 0.0187
Brugia malayi hypoxia-induced factor 1 0.0292 0.0966 0.0966
Echinococcus granulosus acetylcholinesterase 0.2874 1 1
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0028 0.0057
Schistosoma mansoni tyrosine kinase 0.005 0.0117 0.0116
Treponema pallidum fructose-bisphosphate aldolase 0.0582 0.1979 0.7714
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0028 0.0019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0052 0.0051
Loa Loa (eye worm) TOPoisomerase family member 0.0152 0.0474 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0103 0.0308
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0011 0.001
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0152 0.0474 0.1543
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0725 0.2479 0.2479
Echinococcus multilocularis heat shock protein 90 0.0725 0.2479 0.2479
Schistosoma mansoni hypothetical protein 0.0043 0.0094 0.0093
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0011 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0002
Toxoplasma gondii Hsp90 domain-containing protein 0.0409 0.1373 0.4519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Echinococcus granulosus DNA mismatch repair protein Mlh1 0.0023 0.0022 0.0022
Plasmodium falciparum heat shock protein 90, putative 0.0409 0.1373 0.4519
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0003 0.0002
Treponema pallidum heat shock protein 90 0.0748 0.2559 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0011 0.001
Loa Loa (eye worm) carboxylesterase 0.2874 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Plasmodium falciparum heat shock protein 90, putative 0.0475 0.1604 0.5291
Brugia malayi nuclear receptor NHR-88 0.0032 0.0053 0.0053
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Onchocerca volvulus 0.0032 0.0053 0.0299
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0748 0.2559 1
Brugia malayi Carboxylesterase family protein 0.2874 1 1
Schistosoma mansoni tyrosine kinase 0.0154 0.0481 0.048
Entamoeba histolytica heat shock protein 90, putative 0.0877 0.3011 1
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi nuclear receptor RXR 0.0017 0.0001 0.0001
Brugia malayi Furin-like cysteine rich region family protein 0.0154 0.0481 0.0481
Brugia malayi PXA domain containing protein 0.002 0.0011 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0103 0.0103
Echinococcus multilocularis heat shock protein 90 0.0877 0.3011 0.301
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0094 0.0093
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0053 0.0052
Schistosoma mansoni BC026374 protein (S09 family) 0.0486 0.1641 0.1641
Echinococcus multilocularis DNA mismatch repair protein Mlh1 0.0023 0.0022 0.0022
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0206
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Schistosoma mansoni intermediate filament proteins 0.0028 0.0039 0.0038
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0028 0.0057
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0152 0.0474 0.1466
Brugia malayi hypothetical protein 0.0043 0.0094 0.0094
Brugia malayi ecdysteroid receptor 0.0032 0.0053 0.0053
Brugia malayi Probable ClpP-like protease 0.0076 0.0207 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0053 0.0052
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0051
Plasmodium vivax plasmepsin IV, putative 0.006 0.0151 0.0432
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2874 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0486 0.1641 0.1641
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Onchocerca volvulus 0.007 0.0187 0.1095
Onchocerca volvulus 0.0486 0.1641 0.9748
Schistosoma mansoni tyrosine kinase 0.0081 0.0227 0.0226
Brugia malayi hypothetical protein 0.0242 0.0791 0.0791
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0103 0.0271
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0152 0.0474 0.1511
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0152 0.0474 0.178
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0748 0.2559 0.8489
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0152 0.0474 0.1466
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0011 0.001
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.0152 0.0474 0.1511
Toxoplasma gondii DNA topoisomerase 2, putative 0.0152 0.0474 0.1511
Schistosoma mansoni memapsin-2 (A01 family) 0.149 0.5156 0.5156
Echinococcus multilocularis BC026374 protein (S09 family) 0.0486 0.1641 0.1641
Giardia lamblia GTOR 0.0046 0.0103 0.0271
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0053 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Schistosoma mansoni calcium-activated potassium channel 0.0115 0.0344 0.0343
Onchocerca volvulus 0.0025 0.0028 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0038 0.0092
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0498 0.1684 0.1683
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.0032
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0253 0.0253
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0011 0.001
Schistosoma mansoni endoplasmin 0.0877 0.3011 0.301
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0053 0.0052
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0011 0.001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0727
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0152 0.0474 0.1466
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0053 0.0053
Plasmodium vivax aspartyl protease, putative 0.006 0.0151 0.0432
Schistosoma mansoni cathepsin D (A01 family) 0.006 0.0151 0.0151
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0152 0.0474 0.0473
Plasmodium falciparum DNA topoisomerase 2 0.0152 0.0474 0.1511
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0152 0.0474 0.1466
Schistosoma mansoni gliotactin 0.0486 0.1641 0.1641
Schistosoma mansoni hypothetical protein 0.0068 0.0179 0.0178
Echinococcus multilocularis 0.0047 0.0108 0.0107
Echinococcus multilocularis hedgehog 0.0188 0.0599 0.0599
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0011 0.001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0045 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0053 0.0052
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0152 0.0474 0.0473
Schistosoma mansoni acetylcholinesterase 0.0486 0.1641 0.1641
Schistosoma mansoni tyrosine kinase 0.0083 0.0233 0.0233
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0152 0.0474 0.0474
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0053 0.0052
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0027 0.0037 0.0036
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0152 0.0474 0.0473
Loa Loa (eye worm) heat shock protein 90 0.0877 0.3011 0.301
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0103 0.0308
Leishmania major heat shock protein, putative 0.0498 0.1684 0.556
Schistosoma mansoni heat shock protein 0.0877 0.3011 0.301
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0152 0.0474 0.1511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0152 0.0474 0.1511
Mycobacterium ulcerans carboxylesterase, LipT 0.0486 0.1641 0.6131
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0033 0.0043
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0003 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0032 0.0032
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.3434
Brugia malayi Carboxylesterase family protein 0.0486 0.1641 0.1641
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0028 0.0019
Echinococcus granulosus Ankyrin 0.0018 0.0003 0.0003
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0051
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0152 0.0474 0.2801
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0011 0.0011
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0032 0.0032
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0084
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Mycobacterium tuberculosis Possible two component sensor kinase 0.0152 0.0474 0.1466
Brugia malayi Carboxylesterase family protein 0.0486 0.1641 0.1641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.007 0.0198
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0028 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0152 0.0474 0.1466
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.0364 0.0364
Echinococcus granulosus MORC family CW type zinc finger protein 2B 0.0023 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0076 0.0207 0.0206
Plasmodium vivax plasmepsin V, putative 0.006 0.0151 0.0432
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0033 0.0037
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0152 0.0474 0.1761
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0049 0.009
Mycobacterium leprae Probable two-component sensor kinase 0.0152 0.0474 0.1761
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0028 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0039 0.0039
Schistosoma mansoni regulator of G protein signaling 0.002 0.0011 0.001
Schistosoma mansoni single-minded 0.0094 0.0273 0.0272
Schistosoma mansoni DNA mismatch repair protein PMS2 0.0023 0.0022 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0011 0.001
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0003 0.0002
Brugia malayi Eukaryotic aspartyl protease family protein 0.006 0.0151 0.0151
Toxoplasma gondii heat shock protein HSP90 0.0877 0.3011 1
Echinococcus multilocularis epidermal growth factor receptor 0.0083 0.0233 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0047 0.012
Loa Loa (eye worm) hypothetical protein 0.0054 0.0132 0.0131
Mycobacterium ulcerans two component regulator - sensor kinase 0.0152 0.0474 0.1209
Echinococcus multilocularis acetylcholinesterase 0.2874 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Plasmodium vivax heat shock protein, putative 0.0409 0.1373 0.4519
Mycobacterium ulcerans DNA gyrase subunit B 0.0152 0.0474 0.1209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0053 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0026 0.0033 0.0037
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0486 0.1641 0.1641
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0152 0.0474 0.1543
Trypanosoma brucei heat shock protein 90, putative 0.0877 0.3011 1
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0346 0.1154 0.1154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0053 0.0052
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0152 0.0474 0.1511
Loa Loa (eye worm) hypothetical protein 0.006 0.0151 0.0151
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0028 0.0057
Brugia malayi heat shock protein 90 0.0877 0.3011 0.3011
Loa Loa (eye worm) TK/EGFR protein kinase 0.0154 0.0481 0.048
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0022 0.0022
Echinococcus granulosus epidermal growth factor receptor 0.0154 0.0481 0.048
Plasmodium falciparum endoplasmin, putative 0.0538 0.1824 0.603
Plasmodium falciparum plasmepsin IV 0.006 0.0151 0.0432
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0051
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0474 0.0473
Entamoeba histolytica hypothetical protein 0.0043 0.0094 0.0278
Loa Loa (eye worm) aspartic protease BmAsp-1 0.006 0.0151 0.0151
Schistosoma mansoni lamin 0.0028 0.0039 0.0038
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0152 0.0474 0.1209
Echinococcus multilocularis GPCR, family 2 0.0031 0.0052 0.0051
Entamoeba histolytica heat shock protein 90, putative 0.0877 0.3011 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0486 0.1641 0.1641
Trichomonas vaginalis mismatch repair protein Mlh1B (mutL homolog) 0.0023 0.0022 0.0038
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Trypanosoma cruzi heat shock protein 90, putative 0.0877 0.3011 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0486 0.1641 0.6244
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0152 0.0474 0.2801
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0094 0.0093
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0152 0.0474 0.1466
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0053 0.0053
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0103 0.0271
Loa Loa (eye worm) hypothetical protein 0.0068 0.0179 0.0178
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0053 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0011 0.001
Schistosoma mansoni neuroligin 3 (S09 family) 0.0486 0.1641 0.1641
Schistosoma mansoni microrchidia 2a 0.0023 0.0022 0.0022
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0003 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0053 0.0053
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.0937 0.3163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0053 0.0052
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Brugia malayi hypothetical protein 0.0317 0.1052 0.1052
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.006 0.0151 0.0432
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0053 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0011 0.001
Trichomonas vaginalis heat shock protein, putative 0.0386 0.1293 0.4273
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0152 0.0474 0.1466
Echinococcus multilocularis Ankyrin 0.0018 0.0003 0.0003
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0152 0.0474 0.1511
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Loa Loa (eye worm) endoplasmin 0.0877 0.3011 0.301
Brugia malayi Hint module family protein 0.0051 0.0121 0.0121
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0053 0.0053
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0011 0.001
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0028 0.0057
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0053 0.0052
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0028 0.0019
Echinococcus multilocularis carboxylesterase 5A 0.2874 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0049 0.0048
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.006 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0025 0.0028 0.0027
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0011 0.001
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0116 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0053 0.0053
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0011 0.001
Trypanosoma cruzi DNA topoisomerase II, putative 0.0152 0.0474 0.1511
Schistosoma mansoni axis inhibition protein axin 0.002 0.0011 0.001
Echinococcus granulosus carboxylesterase 5A 0.2874 1 1
Plasmodium vivax heat shock protein 86, putative 0.0877 0.3011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0103 0.0308
Plasmodium vivax DNA topoisomerase II, putative 0.0152 0.0474 0.1511
Loa Loa (eye worm) aspartyl protease 6 0.006 0.0151 0.0151
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0053 0.0052
Echinococcus granulosus expressed protein 0.0383 0.1282 0.1281
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.0032
Onchocerca volvulus 0.006 0.0151 0.0884
Schistosoma mansoni axis inhibition protein axin 0.002 0.0011 0.001
Toxoplasma gondii heat shock protein 90, putative 0.0877 0.3011 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0032 0.0076
Schistosoma mansoni cathepsin D (A01 family) 0.006 0.0151 0.0151
Brugia malayi hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0028 0.0057
Loa Loa (eye worm) hypothetical protein 0.0242 0.0791 0.079
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0028 0.0027
Loa Loa (eye worm) hypothetical protein 0.0486 0.1641 0.1641
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0152 0.0474 0.1543
Toxoplasma gondii aspartyl protease ASP1 0.006 0.0151 0.0432
Brugia malayi Pre-SET motif family protein 0.0031 0.0049 0.0049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0053 0.0052
Echinococcus multilocularis musashi 0.0028 0.0039 0.0038
Echinococcus granulosus insulin receptor 0.005 0.0117 0.0116
Echinococcus granulosus geminin 0.0346 0.1154 0.1154
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0049 0.0048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0053 0.0053
Echinococcus granulosus heat shock protein 90 0.0877 0.3011 0.301
Echinococcus granulosus lamin dm0 0.0028 0.0039 0.0038
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0053 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0053 0.0052
Loa Loa (eye worm) hypothetical protein 0.0061 0.0154 0.0153
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0053 0.0052
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0053 0.0299
Schistosoma mansoni heat shock protein 0.0498 0.1684 0.1683
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Trichomonas vaginalis spcc417.12 protein, putative 0.0486 0.1641 0.5436
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0011 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Echinococcus multilocularis lamin 0.0028 0.0039 0.0038
Mycobacterium tuberculosis Probable two component sensor kinase 0.0152 0.0474 0.1466
Toxoplasma gondii aspartyl protease 0.006 0.0151 0.0432
Brugia malayi Protein kinase domain containing protein 0.005 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0028 0.0027
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0103 0.0271
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Leishmania major protein kinase, putative 0.0025 0.0028 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0474 0.1511
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Brugia malayi Death domain containing protein 0.0017 0.0003 0.0003
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0052 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0053 0.0053
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0011 0.001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0486 0.1641 0.6244
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0039 0.0038
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0152 0.0474 0.1511
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0152 0.0474 0.1209
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Loa Loa (eye worm) hypothetical protein 0.0317 0.1052 0.1051
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0053 0.0053
Echinococcus granulosus epidermal growth factor receptor 0.0083 0.0233 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0062 0.0171
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0152 0.0474 0.1466
Loa Loa (eye worm) hypothetical protein 0.0099 0.0289 0.0288
Plasmodium vivax endoplasmin, putative 0.0877 0.3011 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0011 0.001
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0031 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0053 0.0299
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0689 0.0688
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0207 0.0617
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0053 0.0052
Echinococcus multilocularis expressed protein 0.0383 0.1282 0.1281
Trichomonas vaginalis set domain proteins, putative 0.0243 0.0792 0.2605
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0176 0.056 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.0937 0.3592
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0784 0.2687 0.2687
Echinococcus granulosus death domain containing protein 0.0017 0.0003 0.0002
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.006 0.0151 0.0151
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0486 0.1641 0.1641
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0053 0.0052
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0011 0.0011
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.007 0.0161
Plasmodium falciparum plasmepsin V 0.006 0.0151 0.0432
Trypanosoma cruzi heat shock protein 90, putative 0.0725 0.2479 0.8221
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0152 0.0474 0.1511
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.006 0.0151 0.0151
Trypanosoma cruzi heat shock protein 85, putative 0.0877 0.3011 1
Onchocerca volvulus 0.0486 0.1641 0.9748
Echinococcus granulosus heat shock protein 0.0877 0.3011 0.301
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0498 0.1684 0.1683
Giardia lamblia Pms1-like protein 0.0152 0.0474 0.1511
Plasmodium falciparum plasmepsin X 0.006 0.0151 0.0432
Leishmania major heat shock protein 83-1 0.0877 0.3011 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0253 0.0253
Loa Loa (eye worm) carboxylesterase 0.0486 0.1641 0.1641
Echinococcus granulosus neuroligin 0.0486 0.1641 0.1641
Echinococcus granulosus lamin 0.0028 0.0039 0.0038
Loa Loa (eye worm) RGS-3 protein 0.002 0.0011 0.001
Mycobacterium leprae Probable two component sensor kinase MprB 0.0152 0.0474 0.1761
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0053 0.0052
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0028 0.0019
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0152 0.0474 0.1761
Entamoeba histolytica hypothetical protein 0.0043 0.0094 0.0278
Brugia malayi Hsp90 protein 0.0498 0.1684 0.1684
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 0.1979 0.6562
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0207 0.0206
Onchocerca volvulus 0.0486 0.1641 0.9748
Trichomonas vaginalis receptor histidine kinase, putative 0.0152 0.0474 0.1543
Plasmodium vivax DNA gyrase subunit B, putative 0.0152 0.0474 0.1511
Trypanosoma brucei heat shock protein, putative 0.0877 0.3011 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0029 0.0061
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0032 0.0032
Trichomonas vaginalis DNA topoisomerase II, putative 0.0152 0.0474 0.1543
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0103 0.0103
Schistosoma mansoni netrin receptor unc5 0.0017 0.0003 0.0002
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0116 0.0115
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0152 0.0474 0.1543
Onchocerca volvulus 0.0486 0.1641 0.9748
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0152 0.0474 0.1209
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0207 0.0617
Brugia malayi hypothetical protein 0.0026 0.0032 0.0032
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0207 0.0727
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0116 0.0346

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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