TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 291.302 | Formula: C14H17N3O4
H donors: 2 H acceptors: 4 LogP: 2.73 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCCCC1)N/N=C/c1cc(ccc1O)[N+](=O)[O-]
InChi: 1S/C14H17N3O4/c18-13-7-6-12(17(20)21)8-11(13)9-15-16-14(19)10-4-2-1-3-5-10/h6-10,18H,1-5H2,(H,16,19)/b15-9+
InChiKey: YWFZWWKDPLNMRX-OQLLNIDSSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	synuclein, alpha (non A4 component of amyloid precursor)	Starlite/ChEMBL	No references
Homo sapiens	tyrosyl-DNA phosphodiesterase 1	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4E	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	Get druggable targets OG5_129037	All targets in OG5_129037
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	Get druggable targets OG5_129037	All targets in OG5_129037
Trypanosoma congolense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	transcription factor Dp 1	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania major	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210	Get druggable targets OG5_129037	All targets in OG5_129037
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei gambiense	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	tyrosyl-DNA phosphodiesterase 1	Get druggable targets OG5_129037	All targets in OG5_129037
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_129037	All targets in OG5_129037
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	tyrosyl-DNA phosphodiesterase-like protein	Get druggable targets OG5_129037	All targets in OG5_129037
Cryptosporidium parvum	tyrosyl-DNA phodphodiesterase 1 (tdp1)	Get druggable targets OG5_129037	All targets in OG5_129037
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	Get druggable targets OG5_129037	All targets in OG5_129037
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.007	0.0069
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.4048	0.4047
Echinococcus granulosus	cpg binding protein	0.0037	0.0218	0.0217
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.007	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0525	0.0459
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0013	0.0012
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0374	0.0374
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0418	0.3414	0.3346
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.007	0.0069
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0184	0.0184
Echinococcus granulosus	lamin dm0	0.0033	0.0184	0.0183
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.007	0.0069
Schistosoma mansoni	ap endonuclease	0.0023	0.0101	0.0088
Schistosoma mansoni	hypothetical protein	0.0014	0.0026	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0184	0.0183
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0525	0.0524
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0525	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0013	0.0012
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0525	0.0513
Toxoplasma gondii	exonuclease III APE	0.0023	0.0101	0.0032
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0101	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0012
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0166	0.1892
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0038	0.0037
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.8112	0.8112
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0166	0.0097
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0071	0.007
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0418	0.3414	1
Echinococcus granulosus	geminin	0.0205	0.1625	0.1624
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0071	0.0071
Schistosoma mansoni	lamin	0.0033	0.0184	0.0171
Brugia malayi	nuclear hormone receptor	0.0012	0.0013	0.0013
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0184	0.0183
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0013	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0013	0.0013
Brugia malayi	intermediate filament protein	0.0033	0.0184	0.0184
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0013	0.0012
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0101	0.01
Onchocerca volvulus		0.0033	0.0184	0.1196
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0166	0.1892
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0184	0.0171
Brugia malayi	hypothetical protein	0.0148	0.115	0.115
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0013	0.0012
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.007	0.0056
Schistosoma mansoni	hypothetical protein	0.0205	0.1625	0.1614
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.1205	1	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0179	0.0178
Echinococcus multilocularis	lamin dm0	0.0033	0.0184	0.0183
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.1205	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0013	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0013	0.0013
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.4048	0.4047
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.1205	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0013	0.0013
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0202	0.0202
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.007	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0038	0.0037
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0071	0.0506	0.0505
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0026	0.0024
Entamoeba histolytica	hypothetical protein	0.0786	0.6497	0.6461
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.689	0.689
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.007	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0013	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0013	0.0013
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0579	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.008	0.0579	0.0578
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0525	0.128
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0013	0.0012
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0374	0.0373
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.1205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0101	0.0032
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0043	0.0042
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0057	0.0057
Brugia malayi	hypothetical protein	0.002	0.0076	0.0076
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.1205	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0071	0.007
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0256	0.0256
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0184	0.0183
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0374	0.0361
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0418	0.3414	1
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0043	0.0042
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.007	0.0069
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0021	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0043	0.0042
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0013	0.0013
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0462	0.0394
Schistosoma mansoni	lamin	0.0033	0.0184	0.0171
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0013	0.0013
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.1205	1	1
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0418	0.3414	0.3346
Entamoeba histolytica	hypothetical protein	0.1205	1	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0026	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0182	0.144	0.1439
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.1205	1	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0057
Entamoeba histolytica	hypothetical protein	0.0418	0.3414	0.3346
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0166	0.0097
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0166	0.0097
Echinococcus multilocularis	musashi	0.0033	0.0184	0.0183
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0101	0.01
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0166	0.1892
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0418	0.3414	0.5
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0525	0.128
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0415	0.0414
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0415	0.0415
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0527	0.0515
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0166	0.0097
Echinococcus multilocularis	dUTP pyrophosphatase	0.1205	1	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0071	0.007
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.007	0.0056
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.007	0.0069
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0057
Brugia malayi	hypothetical protein	0.0182	0.144	0.144
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.007	0.0056
Echinococcus granulosus	lysine specific demethylase 5A	0.0073	0.0523	0.0522
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.1205	1	1
Leishmania major	hypothetical protein, conserved	0.003	0.0166	0.1892
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0057
Echinococcus granulosus	GPCR family 2	0.0019	0.0071	0.007
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0525	0.0524
Brugia malayi	jmjC domain containing protein	0.0019	0.007	0.007
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0071	0.007
Brugia malayi	steroid hormone receptor	0.0012	0.0013	0.0013
Echinococcus multilocularis	transcription factor Dp 1	0.0046	0.0298	0.0297
Schistosoma mansoni	cpg binding protein	0.0035	0.0202	0.0188
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.008	0.0579	0.0566
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Onchocerca volvulus		0.0182	0.144	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.0523	0.051
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0256	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.0523	0.0522
Onchocerca volvulus	Huntingtin homolog	0.0148	0.115	0.7972
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Schistosoma mansoni	hypothetical protein	0.0041	0.0256	0.0243
Schistosoma mansoni	jumonji domain containing protein	0.0071	0.0506	0.0493
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0415	0.0415
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0013	0.0012
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0374	0.0361
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.1205	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0148	0.115	0.1149
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.1205	1	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.008	0.0579	0.0578
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0013	0.0012
Brugia malayi	jmjC domain containing protein	0.0019	0.007	0.007
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.007	0.0069
Brugia malayi	hypothetical protein	0.003	0.0166	0.0166
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0418	0.3414	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0374	0.0373
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.1205	1	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0101	0.0101
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0057	0.0056
Schistosoma mansoni	hypothetical protein	0.0019	0.0071	0.0057
Brugia malayi	jmjC domain containing protein	0.0071	0.0506	0.0506
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	cpg binding protein	0.0037	0.0218	0.0205
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0101	0.0621
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0101	0.0621
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0202	0.0201
Echinococcus granulosus	lamin	0.0033	0.0184	0.0183
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0071	0.0071
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0374	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0069
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0525	0.0513
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0013	0.0012
Onchocerca volvulus		0.0033	0.0184	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.007
Wolbachia endosymbiont of Brugia malayi	deoxycytidine triphosphate deaminase	0.0418	0.3414	0.3346
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0013	0.0012
Echinococcus granulosus	transcription factor Dp 1	0.0046	0.0298	0.0297
Echinococcus multilocularis	lysine specific demethylase 5A	0.0071	0.0506	0.0505
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.003	0.0166	0.0165
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0101	0.01
Echinococcus multilocularis	geminin	0.0205	0.1625	0.1624
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.008	0.0579	1
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.007	0.0069
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0013	0.0012
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.008	0.0579	0.0579
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0374	0.0361
Echinococcus multilocularis	cpg binding protein	0.0037	0.0218	0.0217
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0071	0.007
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.689	0.689
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.1205	1	1
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.008	0.0579	0.0578
Echinococcus granulosus	phd:f box containing protein	0.0019	0.007	0.0069
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0374	0.0373
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0013	0.0013
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.008	0.0579	0.0482
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0021	0.0086	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0012
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0579	1
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0013	0.0012
Loa Loa (eye worm)	dUTP diphosphatase	0.1205	1	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0101	0.0621
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0071	0.007
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.1205	1	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0218	0.0205
Brugia malayi	jmjC domain containing protein	0.0019	0.007	0.007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0012
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0101	0.0621
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0013	0.0012
Onchocerca volvulus	Huntingtin homolog	0.0148	0.115	0.7972
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0525	0.8949
Schistosoma mansoni	ap endonuclease	0.0023	0.0101	0.0088
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0071	0.0506	0.0505
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0374	0.0373
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.1205	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.007	0.0069
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0013	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0013	0.0013
Entamoeba histolytica	hypothetical protein	0.0786	0.6497	0.6461
Schistosoma mansoni	hypothetical protein	0.0494	0.4048	0.404
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0013	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0013	0.0013
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0148	0.115	0.1149
Echinococcus granulosus	intermediate filament protein	0.0033	0.0184	0.0183
Brugia malayi	jmjC domain containing protein	0.0019	0.007	0.007
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.008	0.0579	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0013	0.0012
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0013	0.0012
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.007	0.0056
Echinococcus granulosus	dUTP pyrophosphatase	0.1205	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0013	0.0012
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0101	0.0032
Onchocerca volvulus		0.0035	0.0202	0.132
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0013	0.0012
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.689	0.6886
Loa Loa (eye worm)	hypothetical protein	0.006	0.0415	0.0414
Echinococcus multilocularis	lamin	0.0033	0.0184	0.0183
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0525	0.128
Entamoeba histolytica	hypothetical protein	0.1205	1	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.007	0.0069
Brugia malayi	jmjC domain containing protein	0.0073	0.0523	0.0523
Brugia malayi	ecdysteroid receptor	0.0012	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.0205	0.1625	0.1614
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0073	0.0523	0.051

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.5012 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.3096 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (binding)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3189301

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1873891