Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0562 | 0.0476 | 0.0503 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0562 | 0.0476 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | nuclear hormone receptor | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.5569 | 0.9466 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.049 | 0.0346 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0562 | 0.0476 | 0.0617 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.0346 | 0.0365 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0562 | 0.0476 | 0.0617 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.049 | 0.0346 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0562 | 0.0476 | 0.0617 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0562 | 0.0476 | 0.0663 |
Echinococcus granulosus | FTZ F1 alpha | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0562 | 0.0476 | 0.0617 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0562 | 0.0476 | 0.0617 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0562 | 0.0476 | 0.0503 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0562 | 0.0476 | 0.0135 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0562 | 0.0476 | 0.0663 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | steroid hormone receptor | 0.0562 | 0.0476 | 0.0503 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.4594 | 0.7715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0562 | 0.0476 | 0.0503 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0562 | 0.0476 | 0.0663 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0562 | 0.0476 | 0.0617 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.049 | 0.0346 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.0346 | 0.0365 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0562 | 0.0476 | 0.0503 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | nuclear hormone receptor | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | thyroid hormone receptor | 0.0562 | 0.0476 | 0.0617 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0562 | 0.0476 | 0.0617 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.5304 | 0.899 | 0.9497 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0562 | 0.0476 | 0.0135 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0562 | 0.0476 | 0.0503 |
Schistosoma mansoni | coup transcription factor | 0.0562 | 0.0476 | 0.0617 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | serotonin transporter b | 0.049 | 0.0346 | 0.0365 |
Brugia malayi | ecdysteroid receptor | 0.0562 | 0.0476 | 0.0503 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0562 | 0.0476 | 0.0663 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0562 | 0.0476 | 0.0503 |
Schistosoma mansoni | thyroid hormone receptor | 0.0562 | 0.0476 | 0.0617 |
Loa Loa (eye worm) | norepinephrine transporter | 0.049 | 0.0346 | 0.0365 |
Loa Loa (eye worm) | hypothetical protein | 0.049 | 0.0346 | 0.0365 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0562 | 0.0476 | 0.0663 |
Echinococcus multilocularis | serotonin transporter | 0.049 | 0.0346 | 0.0481 |
Onchocerca volvulus | 0.0562 | 0.0476 | 0.0135 | |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0562 | 0.0476 | 0.0617 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0562 | 0.0476 | 0.0503 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.4594 | 0.7715 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0562 | 0.0476 | 0.0663 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0562 | 0.0476 | 0.0663 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.049 | 0.0346 | 0.0448 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0562 | 0.0476 | 0.0617 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0562 | 0.0476 | 0.0503 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0562 | 0.0476 | 0.0617 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.4297 | 0.7182 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.049 | 0.0346 | 0.0365 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0562 | 0.0476 | 0.0503 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0562 | 0.0476 | 0.0617 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0562 | 0.0476 | 0.0503 |
Brugia malayi | nuclear hormone receptor | 0.5569 | 0.9466 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Echinococcus granulosus | serotonin transporter | 0.049 | 0.0346 | 0.0448 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0562 | 0.0476 | 0.0663 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0562 | 0.0476 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0562 | 0.0476 | 0.0503 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0562 | 0.0476 | 0.0663 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0562 | 0.0476 | 0.0503 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Aqueous solubility | = 1000000 M l-1 | Aqueous solubility of the compound at 37 degree centigrade at pH 7.38 | ChEMBL. | 2913295 |
Increase (functional) | = 26 % | Percent increase in oxygen consumption after seven daily doses of test compound given intramuscularly, with concentration of compound at 3.3 mg/kg | ChEMBL. | 2913295 |
Increase (functional) | = 31 % | Percent increase in oxygen consumption after seven daily doses of test compound given perorally, with concentration of compound at 5 mg/kg | ChEMBL. | 2913295 |
logD | = 0.6 | Partition coefficient of the compound at 25 degree centigrade in octanol/aqueous buffer at pH 6.02 | ChEMBL. | 2913295 |
Relative ED50 (functional) | 0 | Potency of the compound for induction of GPDH(mitochondrialcytochrome C 3-phosphoglycerate oxidoreductase) was measured 48 hr after single im injection relative to T3 in heart; LM=low maximal response after 2 daily doses of 50 mg/kg | ChEMBL. | 2913295 |
Relative ED50 (functional) | = 1.2 | Potency of the compound for induction of GPDH(mitochondrial cytochrome C3-phosphoglycerate oxidoreductase) was measured 48 hours after single intramuscular injection relative to T3 in liver | ChEMBL. | 2913295 |
Relative IC50 (binding) | = 0.49 | Binding affinity to the thyroid hormone receptor was determined in vitro in isolated nuclei of rat liver relative to 3,5,3' triiodothyronine | ChEMBL. | 2913295 |
Relative IC50 (binding) | = 0.53 | Binding affinity to thyroid hormone receptor beta, relative to 3,5,3' triiodothyronine receptor, in isolated nuclei of heart | ChEMBL. | 2913295 |
Relative ID50 (binding) | = 0.5 | In vivo binding affinity for 3,5,3'' triiodothyronine receptor of heart nuclei 1 hr after intravenous administration | ChEMBL. | 2913295 |
Relative ID50 (binding) | = 13 | In vivo binding affinity for 3,5,3' triiodothyronine receptor of liver nuclei 1 hour after intravenous administration | ChEMBL. | 2913295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.