TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 395.493 | Formula: C20H33N3O5
H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@H]1[C@H]2N(CC[C@@H]2N(C1=O)C(=O)C)C(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C
InChi: 1S/C20H33N3O5/c1-8-13-16-14(23(12(4)24)17(13)25)9-10-22(16)18(26)15(11(2)3)21-19(27)28-20(5,6)7/h11,13-16H,8-10H2,1-7H3,(H,21,27)/t13-,14-,15-,16+/m0/s1
InChiKey: WSTYSIWMSQMTSY-YHUYYLMFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Plasmodium falciparum	protein kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0157	0.011	0.0112
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.011	0.011
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.9708	0.984	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0157	0.011	0.0112
Brugia malayi	integrin-linked kinase	0.0157	0.011	0.0112
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.011	0.011
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	ephrin receptor	0.0157	0.011	0.011
Echinococcus multilocularis	transfer RNA-Thr	0.0157	0.011	0.0112
Echinococcus multilocularis	insulin receptor	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0157	0.011	0.0112
Trypanosoma cruzi	protein kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0157	0.011	0.0112
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/INSR protein kinase	0.0157	0.011	0.0112
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	ankyrin repeat protein	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0157	0.011	0.0112
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Trichomonas vaginalis	AGC family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0157	0.011	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.011	0.0112
Brugia malayi	Receptor family ligand binding region containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0157	0.011	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Brugia malayi	Tyrosine-protein kinase abl-1	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase csk	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase HCK	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	hypothetical protein	0.0157	0.011	0.011
Leishmania major	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/RYK protein kinase	0.0157	0.011	0.0112
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0157	0.011	0.0112
Trypanosoma cruzi	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.9708	0.984	1
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	receptor protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Loa Loa (eye worm)	TK/ACK protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Trichomonas vaginalis	protein kinase atn1, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	serine/threonine protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0157	0.011	0.0112
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Onchocerca volvulus		0.0157	0.011	1
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein, conserved	0.0157	0.011	0.5
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0157	0.011	0.011
Trichomonas vaginalis	TK family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine kinase	0.0157	0.011	0.0112
Echinococcus granulosus	integrin linked protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase csk	0.0157	0.011	0.0112
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	SRC-1	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Giardia lamblia	Protein 21.1	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/EPH protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	STE family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Leishmania major	protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0157	0.011	0.0112
Echinococcus granulosus	raf serine:threonine protein kinase	0.0157	0.011	0.0112
Echinococcus granulosus	c src tyrosine kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	activated cdc42 kinase 1	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/Met protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Echinococcus granulosus	insulin receptor	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0157	0.011	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus multilocularis	c src tyrosine kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase csk	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Echinococcus multilocularis	integrin linked protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0157	0.011	0.011
Toxoplasma gondii	protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0157	0.011	0.0112
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/ROR protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0157	0.011	0.0112
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus multilocularis	epidermal growth factor receptor	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Plasmodium falciparum	tyrosine kinase-like protein	0.0157	0.011	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0157	0.011	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0157	0.011	0.0112
Brugia malayi	Raf kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.9708	0.984	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.9708	0.984	1
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Toxoplasma gondii	STE kinase	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Blk	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0157	0.011	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0157	0.011	0.0112
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	SRC-1	0.0157	0.011	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Echinococcus granulosus	protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Loa Loa (eye worm)	TK/CSK protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0157	0.011	0.011
Echinococcus granulosus	protein tyrosine kinase	0.0157	0.011	0.0112
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0157	0.011	0.0112
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	epidermal growth factor receptor	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase shark	0.0157	0.011	0.0112
Entamoeba histolytica	cysteine surface protein, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	receptor protein kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosin kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0157	0.011	0.0112
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0157	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Plasmodium falciparum	tyrosine kinase-like protein	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Schistosoma mansoni	ephrin receptor	0.0157	0.011	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase csk	0.0157	0.011	0.0112
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	serine/threonine RGC	0.0157	0.011	0.011
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.9708	0.984	1
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0157	0.011	0.0112
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Brugia malayi	hypothetical protein	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosin kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Leishmania major	hypothetical protein, conserved	0.0157	0.011	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Echinococcus granulosus	activated cdc42 kinase 1	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Brugia malayi	hypothetical protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/DDR protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Brugia malayi	Guanylyl cyclase protein 23	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase csk	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0157	0.011	0.0112
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0157	0.011	0.0112
Schistosoma mansoni	protein tyrosine kinase	0.0157	0.011	0.011
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0157	0.011	0.0112
Giardia lamblia	Kinase	0.0157	0.011	0.5
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	hypothetical protein	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0157	0.011	0.0112
Echinococcus multilocularis	protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Trypanosoma brucei	protein kinase, putative	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0157	0.011	1
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	activin receptor type	0.0157	0.011	0.0112
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0157	0.011	0.011
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0157	0.011	0.0112
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0157	0.011	0.0112
Brugia malayi	protein-tyrosine kinase	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Plasmodium vivax	protein kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0157	0.011	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0157	0.011	0.0112
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Echinococcus multilocularis	heat shock protein 70	0.0157	0.011	0.0112
Giardia lamblia	Kinase, NEK	0.0157	0.011	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	FL cytokine receptor	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus granulosus	ephrin type A receptor 4 A	0.0157	0.011	0.0112
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0157	0.011	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0157	0.011	1
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Plasmodium falciparum	protein kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0157	0.011	0.011
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0157	0.011	0.0112
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Echinococcus multilocularis	activin receptor type	0.0157	0.011	0.0112
Onchocerca volvulus		0.0157	0.011	1
Echinococcus granulosus	tyrosine kinase	0.0157	0.011	0.0112
Giardia lamblia	Kinase, NEK	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Entamoeba histolytica	hypothetical protein	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Plasmodium falciparum	protein kinase, putative	0.0157	0.011	0.5
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine kinase	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Brugia malayi	ephrin receptor 1 precursor	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK/ALK protein kinase	0.0157	0.011	0.0112
Loa Loa (eye worm)	TK protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	protein tyrosine kinase	0.0157	0.011	0.0112
Schistosoma mansoni	tyrosine kinase	0.0157	0.011	0.011
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0157	0.011	0.0112
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Brugia malayi	SH2 domain containing protein	0.0157	0.011	0.0112
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.9708	0.984	1
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0157	0.011	0.5
Onchocerca volvulus		0.0157	0.011	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0157	0.011	0.0112
Entamoeba histolytica	protein kinase domain containing protein	0.0157	0.011	0.5
Entamoeba histolytica	protein kinase, putative	0.0157	0.011	0.5
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0157	0.011	0.011
Brugia malayi	Protein kinase domain containing protein	0.0157	0.011	0.0112
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0157	0.011	0.0112
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Schistosoma mansoni	protein kinase	0.0157	0.011	0.011
Trichomonas vaginalis	TKL family protein kinase	0.0157	0.011	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0157	0.011	0.0112
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0157	0.011	0.0112
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0157	0.011	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0157	0.011	0.0112
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0157	0.011	0.0112

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 28 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 18 h preincubation in chromogenic assay	ChEMBL.	12419361
IC50 (binding)	= 28 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 18 h preincubation in chromogenic assay	ChEMBL.	12419361
IC50 (binding)	= 99 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 4 hr preincubation in chromogenic assay	ChEMBL.	12419361
IC50 (binding)	= 99 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 4 hr preincubation in chromogenic assay	ChEMBL.	12419361
IC50 (binding)	= 172 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 18 h preincubation in fluorogenic assay	ChEMBL.	12419361
IC50 (binding)	= 172 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 18 h preincubation in fluorogenic assay	ChEMBL.	12419361
IC50 (binding)	= 341 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 4 hr preincubation in fluorogenic assay	ChEMBL.	12419361
IC50 (binding)	= 341 uM	Inhibitory concentration of the compound against hepatitis C virus NS3/4A protease on 4 hr preincubation in fluorogenic assay	ChEMBL.	12419361

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 187440