Detailed information for compound 1874773

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 296.347 | Formula: C15H12N4OS
  • H donors: 2 H acceptors: 2 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccs1)N/N=C\c1c[nH]nc1c1ccccc1
  • InChi: 1S/C15H12N4OS/c20-15(13-7-4-8-21-13)19-17-10-12-9-16-18-14(12)11-5-2-1-3-6-11/h1-10H,(H,16,18)(H,19,20)/b17-10-
  • InChiKey: GTMDXSHLVKKCDT-YVLHZVERSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RecQ helicase 0.0029 0.038 0.0539
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.024 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.024 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0067 0.1233 0.175
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0073
Brugia malayi Integrin beta pat-3 precursor 0.0328 0.7046 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.038 1
Giardia lamblia Tenascin-37 0.0014 0.0051 0.2132
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.024 0.034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0073
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0079 0.0835
Brugia malayi hypothetical protein 0.0067 0.1233 0.175
Giardia lamblia High cysteine protein 0.0014 0.0051 0.2132
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0301 1
Echinococcus multilocularis integrin alpha 3 0.0052 0.0884 0.1254
Echinococcus multilocularis fibrillin 1 0.0014 0.0051 0.0073
Toxoplasma gondii exonuclease III APE 0.0023 0.024 1
Brugia malayi EGF-like domain containing protein 0.0014 0.0051 0.0073
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0244 0.0244
Echinococcus multilocularis integrin alpha ps 0.0052 0.0884 0.1254
Schistosoma mansoni hypothetical protein 0.0205 0.4299 0.4299
Toxoplasma gondii hypothetical protein 0.0014 0.0051 0.2132
Echinococcus granulosus bloom syndrome protein 0.0029 0.038 0.0539
Echinococcus granulosus integrin beta 2 0.0328 0.7046 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.024 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.2989 0.4242
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0073
Schistosoma mansoni hypothetical protein 0.0052 0.0884 0.0884
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.024 0.5
Giardia lamblia Neurogenic locus notch-like protein 0.0014 0.0051 0.2132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.024 0.034
Echinococcus multilocularis fibrillin 2 0.0014 0.0051 0.0073
Brugia malayi EGF-like domain containing protein 0.0014 0.0051 0.0073
Echinococcus granulosus fibrillin 1 0.0014 0.0051 0.0073
Giardia lamblia High cysteine protein 0.0014 0.0051 0.2132
Echinococcus multilocularis integrin beta 2 0.0328 0.7046 1
Schistosoma mansoni hypothetical protein 0.0205 0.4299 0.4299
Giardia lamblia Tenascin-like 0.0014 0.0051 0.2132
Brugia malayi EGF-like domain containing protein 0.0014 0.0051 0.0073
Echinococcus multilocularis adam 0.0014 0.0051 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.024 1
Echinococcus multilocularis protein jagged 2 0.0014 0.0051 0.0073
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.024 0.5
Echinococcus multilocularis bloom syndrome protein 0.0029 0.038 0.0539
Loa Loa (eye worm) integrin alpha pat-2 0.0108 0.2134 0.3028
Echinococcus multilocularis integrin alpha ps 0.0108 0.2134 0.3028
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.024 0.5738
Echinococcus granulosus adam 0.0014 0.0051 0.0073
Loa Loa (eye worm) hypothetical protein 0.0056 0.0983 0.1395
Loa Loa (eye worm) hypothetical protein 0.0052 0.0884 0.1254
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.024 1
Echinococcus granulosus fibrillin 2 0.0014 0.0051 0.0073
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0165 0.689
Giardia lamblia Tenascin-X 0.0014 0.0051 0.2132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.024 0.5
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.024 0.034
Loa Loa (eye worm) hypothetical protein 0.0056 0.0983 0.1395
Giardia lamblia Tenascin precursor 0.0014 0.0051 0.2132
Echinococcus granulosus integrin alpha 3 0.0052 0.0884 0.1254
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.038 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.024 0.5738
Echinococcus granulosus integrin alpha ps 0.0108 0.2134 0.3028
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.038 0.0539
Schistosoma mansoni integrin beta subunit 0.0261 0.5546 0.5546
Loa Loa (eye worm) hypothetical protein 0.0067 0.1233 0.175
Giardia lamblia hypothetical protein 0.0014 0.0051 0.2132
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0052 0.0884 0.1254
Schistosoma mansoni integrin alpha-ps 0.0108 0.2134 0.2134
Echinococcus multilocularis integrin alpha ps 0.0108 0.2134 0.3028
Brugia malayi EGF-like domain containing protein 0.0014 0.0051 0.0073
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.024 0.034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.024 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0014 0.0051 0.0073
Echinococcus granulosus geminin 0.0205 0.4299 0.6102
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.00000000012161 0.0000000050724
Schistosoma mansoni ap endonuclease 0.0023 0.024 0.024
Onchocerca volvulus 0.0014 0.0051 0.5
Loa Loa (eye worm) integrin beta-2 0.0328 0.7046 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.024 0.7958
Schistosoma mansoni integrin alpha 0.0108 0.2134 0.2134
Brugia malayi Integrin alpha pat-2 precursor 0.0108 0.2134 0.3028
Loa Loa (eye worm) hypothetical protein 0.0052 0.0884 0.1254
Echinococcus multilocularis geminin 0.0205 0.4299 0.6102
Giardia lamblia Neurogenic locus Notch protein precursor 0.0014 0.0051 0.2132
Brugia malayi Kelch motif family protein 0.0067 0.1233 0.175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.024 1
Echinococcus granulosus integrin alpha ps 0.0052 0.0884 0.1254
Schistosoma mansoni integrin alpha-ps 0.0056 0.0983 0.0983

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 195 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] ChEMBL. No reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8199 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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