Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1306 | 0.137 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2403 | 0.2578 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.3073 | 0.3273 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2403 | 0.2578 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0583 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3073 | 0.3049 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.9321 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.3073 | 0.3273 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.0583 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.0583 | 0.5 |
Brugia malayi | RNA binding protein | 0.0072 | 0.3073 | 0.3297 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.9321 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.0583 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3073 | 0.3049 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.3073 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0583 | 0.0591 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.3073 | 0.3297 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0034 | 0.0037 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0034 | 0.0037 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.9321 | 0.9318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3073 | 0.3049 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.9321 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0583 | 0.0626 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.3073 | 0.3049 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.9321 | 0.9318 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3073 | 0.3049 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.3073 | 0.3049 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1306 | 0.1402 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1306 | 0.1277 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2403 | 0.2551 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2403 | 0.2551 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0583 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.3073 | 0.3273 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.3073 | 0.3297 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.9321 | 0.9318 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.0583 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 6.3096 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.