Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0104 | 0.0171 | 0.0171 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2032 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.0167 | 0.0167 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2032 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2032 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2032 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0604 | 0.2716 | 0.2126 |
Echinococcus multilocularis | tumor protein p63 | 0.0296 | 0.1145 | 0.0428 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0604 | 0.2716 | 0.2126 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0104 | 0.0171 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1112 | 0.1112 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2032 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2032 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2032 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2032 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0604 | 0.2716 | 0.2716 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2032 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2032 | 1 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0104 | 0.0171 | 0.0171 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2032 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.0167 | 0.0167 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0289 | 0.1112 | 0.1112 |
Echinococcus granulosus | tumor protein p63 | 0.0296 | 0.1145 | 0.0428 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2032 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.4 nM | Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells | ChEMBL. | 12951128 |
Ki (binding) | = 4.4 nM | Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells | ChEMBL. | 12951128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.