Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | corticotropin releasing hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Schistosoma japonicum | IPR001879,Hormone receptor, extracellular,domain-containing | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130760 | All targets in OG5_130760 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | corticotropin releasing hormone receptor 1 | 444 aa | 445 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Brugia malayi | Carboxylesterase family protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium falciparum | plasmepsin II | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2995 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0245 | 0.0582 | 0.0582 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Schistosoma mansoni | gliotactin | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.2995 | 1 | 1 |
Plasmodium falciparum | plasmepsin VIII, putative | 0.0076 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium falciparum | plasmepsin III | 0.0076 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0506 | 0.1475 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0506 | 0.1475 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0506 | 0.1475 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2995 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2995 | 1 | 1 |
Toxoplasma gondii | aspartyl protease | 0.0076 | 0 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0506 | 0.1475 | 0.1475 |
Onchocerca volvulus | 0.0506 | 0.1475 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.2995 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium vivax | aspartyl protease, putative | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin X | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin VI | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | 0.0506 | 0.1475 | 1 | |
Schistosoma mansoni | acetylcholinesterase | 0.0506 | 0.1475 | 0.1475 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0506 | 0.1475 | 0.1475 |
Plasmodium falciparum | plasmepsin V | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | 0.0506 | 0.1475 | 1 | |
Plasmodium vivax | aspartyl proteinase, putative | 0.0076 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0076 | 0 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium vivax | aspartyl protease, putative | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.0441 | 0.0441 |
Plasmodium falciparum | plasmepsin IX | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0506 | 0.1475 | 0.1475 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0506 | 0.1475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.1882 | 0.6185 | 0.6185 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0506 | 0.1475 | 0.5 |
Toxoplasma gondii | eukaryotic aspartyl protease superfamily protein | 0.0076 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0204 | 0.0441 | 0.0441 |
Echinococcus granulosus | acetylcholinesterase | 0.2995 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2995 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.2995 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2995 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.2995 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0506 | 0.1475 | 0.1475 |
Onchocerca volvulus | 0.0506 | 0.1475 | 1 | |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0076 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin I | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0582 | 0.0582 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2995 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium vivax | plasmepsin V, putative | 0.0076 | 0 | 0.5 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0076 | 0 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | carboxylesterase | 0.0506 | 0.1475 | 0.1475 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0506 | 0.1475 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0506 | 0.1475 | 0.1475 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2995 | 1 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0076 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0506 | 0.1475 | 0.1475 |
Plasmodium falciparum | plasmepsin IV | 0.0076 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0076 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0506 | 0.1475 | 0.1475 |
Echinococcus granulosus | neuroligin | 0.0506 | 0.1475 | 0.1475 |
Plasmodium falciparum | plasmepsin VII | 0.0076 | 0 | 0.5 |
Onchocerca volvulus | 0.0506 | 0.1475 | 1 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0506 | 0.1475 | 0.1475 |
Plasmodium vivax | aspartyl protease, putative | 0.0076 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18 nM | Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production | ChEMBL. | 12951128 |
IC50 (functional) | = 18 nM | Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production | ChEMBL. | 12951128 |
Ki (binding) | = 4.4 nM | Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells | ChEMBL. | 12951128 |
Ki (binding) | = 4.4 nM | Binding affinity towards Corticotropin releasing factor receptor 1 was measured through displacement of [125I]-sauvagine expressed in HEK293 cells | ChEMBL. | 12951128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.