Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0001 M | Inhibitory activity of the compound against Angiotensin I converting enzyme (ACE) from human blood serum | ChEMBL. | 12852763 |
IC50 (binding) | = 0.0001 M | Inhibitory activity of the compound against Angiotensin I converting enzyme (ACE) from rat cortex brain membrane | ChEMBL. | 12852763 |
IC50 (binding) | = 0.0001 M | Inhibitory activity of the compound against Angiotensin I converting enzyme (ACE) from human blood serum | ChEMBL. | 12852763 |
IC50 (binding) | = 0.0001 M | Inhibitory activity of the compound against Angiotensin I converting enzyme (ACE) from rat cortex brain membrane | ChEMBL. | 12852763 |
IC50 (binding) | = 0.002 M | Inhibitory activity of the compound against neutral endopeptidase (NEP) from rat cortex brain membrane | ChEMBL. | 12852763 |
IC50 (binding) | = 0.002 M | Inhibitory activity of the compound against neutral endopeptidase (NEP) from rat cortex brain membrane | ChEMBL. | 12852763 |
Inhibition (binding) | = 18 % | Inhibitory activity of compound at 1*10e-4 M against Angiotensin I converting enzyme (ACE) from bovine kidney | ChEMBL. | 12852763 |
Inhibition (binding) | = 18 % | Inhibitory activity of compound at 1*10e-4 M against Angiotensin I converting enzyme (ACE) from bovine kidney | ChEMBL. | 12852763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.