Detailed information for compound 1875853

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 414.049 | Formula: C14H10Br2N2O3
  • H donors: 3 H acceptors: 3 LogP: 4.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1cc(/C=N/Nc2cccc(c2)C(=O)O)c(c(c1)Br)O
  • InChi: 1S/C14H10Br2N2O3/c15-10-4-9(13(19)12(16)6-10)7-17-18-11-3-1-2-8(5-11)14(20)21/h1-7,18-19H,(H,20,21)/b17-7+
  • InChiKey: KXEFYLLVDPYZBT-REZTVBANSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Human immunodeficiency virus 1 Envelope glycoprotein gp160 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Plasmodium falciparum heat shock protein 90, putative Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii heat shock protein 83 Get druggable targets OG5_144951 All targets in OG5_144951
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Hsp90 domain-containing protein Get druggable targets OG5_144951 All targets in OG5_144951
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Theileria parva heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum heat shock protein 90, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis heat shock protein 90 Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax heat shock protein, putative Get druggable targets OG5_144951 All targets in OG5_144951
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.042 0.1109
Brugia malayi aspartic protease BmAsp-1, identical 0.0023 0.0031 0.0109
Trypanosoma brucei aminopeptidase, putative 0.0243 0.0735 0.2594
Schistosoma mansoni hypothetical protein 0.0372 0.1149 0.1144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.0711 0.3296
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Plasmodium falciparum thioredoxin reductase 0.0093 0.0255 0.0398
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0243 0.0735 0.2594
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0079 0.0129
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.009 0.0238
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0763 0.2018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.0635 0.2943
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0013 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.004
Plasmodium falciparum plasmepsin I 0.0023 0.0031 0.0035
Echinococcus granulosus Ankyrin 0.0015 0.0006 0.0001
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0032 0.0218
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0031 0.0079
Brugia malayi POT family protein 0.0042 0.0093 0.0336
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Brugia malayi hypothetical protein 0.0023 0.0031 0.0109
Plasmodium vivax heat shock protein 86, putative 0.0016 0.0009 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.0068
Onchocerca volvulus 0.0015 0.0006 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Schistosoma mansoni DNA polymerase eta 0.0054 0.0131 0.0126
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.0255 0.0877
Plasmodium vivax SET domain protein, putative 0.0036 0.0073 0.0118
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0021 0.0024 0.0069
Brugia malayi Matrixin family protein 0.0018 0.0016 0.0054
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.1149 0.3039
Echinococcus multilocularis leucyl aminopeptidase 0.0116 0.033 0.086
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0061 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0146
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Onchocerca volvulus 0.0023 0.0031 0.0093
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0243 0.0735 0.1934
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0048 0.0139
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.011
Mycobacterium ulcerans leucyl aminopeptidase 0.0683 0.2145 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0032 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0032 0.0116
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0089 0.0243 0.0237
Echinococcus multilocularis apoptotic protease activating factor 1 0.0095 0.0262 0.068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.0635 0.2943
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0318 0.0841
Loa Loa (eye worm) endoplasmin 0.0016 0.0009 0.0023
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2628 0.2624
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0318 0.0841
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0032 0.0084
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0502 0.1317
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0402 0.1247 0.1243
Entamoeba histolytica hypothetical protein 0.0043 0.0097 0.0722
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0131 0.0474
Echinococcus multilocularis leucyl aminopeptidase 0.0116 0.033 0.086
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0017 0.0013 0.0007
Schistosoma mansoni hypothetical protein 0.0026 0.004 0.0034
Echinococcus multilocularis heat shock protein 90 0.0016 0.0009 0.001
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0318 0.2565
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0583 0.1824 0.6486
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Schistosoma mansoni caspase-7 (C14 family) 0.0095 0.0262 0.0257
Echinococcus granulosus expressed conserved protein 0.0112 0.0316 0.0822
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0116 0.033 0.0871
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0055 0.1366
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0683 0.2145 1
Trypanosoma cruzi heat shock protein, putative 0.0021 0.0024 0.0053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0319
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Brugia malayi Peptidase family M1 containing protein 0.0243 0.0735 0.267
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0005 0.000000020152
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0009 0.0028
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0395 0.1223 0.1219
Brugia malayi glutathione reductase 0.0093 0.0255 0.0924
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0583 0.1824 0.6486
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0318 0.2545
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0116 0.033 0.1197
Leishmania major DNA polymerase eta, putative 0.0054 0.0131 0.0435
Echinococcus granulosus aminopeptidase N 0.0872 0.2752 0.7279
Onchocerca volvulus 0.0053 0.0128 0.0449
Plasmodium vivax plasmepsin IV, putative 0.0023 0.0031 0.0049
Echinococcus granulosus neuroligin 0.0015 0.0006 0.0001
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0243 0.0735 0.1945
Schistosoma mansoni hypothetical protein 0.0053 0.0128 0.0123
Toxoplasma gondii leucyl aminopeptidase LAP 0.0683 0.2145 0.3471
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.0005 0.0008
Brugia malayi MH2 domain containing protein 0.0144 0.042 0.1523
Plasmodium vivax heat shock protein 90, putative 0.0021 0.0024 0.0038
Plasmodium falciparum plasmepsin VI 0.0023 0.0031 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.002
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0013 0.0021
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0073 0.0118
Plasmodium falciparum glutathione reductase 0.0093 0.0255 0.0398
Echinococcus multilocularis tumor protein p63 0.0408 0.1265 0.3339
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0032 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0079
Plasmodium vivax aspartyl protease, putative 0.0023 0.0031 0.0049
Brugia malayi Uncoordinated protein 44 0.0015 0.0005 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0032 0.0218
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0202 0.0521
Echinococcus multilocularis caspase 2 0.0095 0.0262 0.068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Toxoplasma gondii subtilisin SUB12 0.0015 0.0005 0.0008
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0031 0.0035
Brugia malayi hypothetical protein 0.0017 0.0012 0.004
Echinococcus multilocularis protein dispatched 1 0.0058 0.0144 0.0368
Onchocerca volvulus 0.0395 0.1223 0.4437
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0202 0.0521
Brugia malayi Matrixin family protein 0.0044 0.0098 0.0352
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.0635 0.2943
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0018 0.0016 0.001
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0318 0.1104
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0031 0.0049
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0121 0.0307
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2628 0.6951
Onchocerca volvulus 0.0025 0.0038 0.0119
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0097 0.0092
Echinococcus multilocularis lamin 0.0025 0.0038 0.0086
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0048 0.0347
Onchocerca volvulus Matrix metalloproteinase homolog 0.004 0.0086 0.0295
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0032 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Echinococcus multilocularis snurportin 1 0.0372 0.1149 0.303
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.0255 0.0673
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0121 0.0307
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0061 0.0098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Plasmodium falciparum thioredoxin reductase 0.0032 0.0061 0.0083
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0395 0.1223 1
Entamoeba histolytica hypothetical protein 0.0028 0.0048 0.0321
Loa Loa (eye worm) matrixin family protein 0.004 0.0086 0.0226
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.004
Brugia malayi Pre-SET motif family protein 0.0036 0.0073 0.0264
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0256
Echinococcus granulosus heat shock protein 90 0.0016 0.0009 0.001
Echinococcus multilocularis Ankyrin 0.0015 0.0006 0.0001
Echinococcus granulosus bloom syndrome protein 0.002 0.0021 0.0041
Loa Loa (eye worm) aminopeptidase N 0.0395 0.1223 0.3237
Echinococcus multilocularis lamin dm0 0.0025 0.0038 0.0086
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0012
Onchocerca volvulus 0.0015 0.0006 0.0003
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0005 0.0013
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Brugia malayi Augmenter of liver regeneration 0.0041 0.009 0.0327
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0055 0.0378
Toxoplasma gondii aminopeptidase n, putative 0.1942 0.618 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0061 0.0184
Brugia malayi Pepsin A precursor 0.0023 0.0031 0.0109
Toxoplasma gondii aspartyl protease 0.0023 0.0031 0.0049
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0061 0.0184
Toxoplasma gondii hypothetical protein 0.0015 0.0005 0.0008
Echinococcus multilocularis aminopeptidase N 0.0872 0.2752 0.7279
Schistosoma mansoni heat shock protein 0.0016 0.0009 0.0004
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0061 0.0256
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0041 0.0115
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0125 0.0358 0.0933
Leishmania major hypothetical protein, conserved 0.0026 0.0041 0.0115
Echinococcus granulosus tumor protein p63 0.0408 0.1265 0.3339
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0021 0.0124
Echinococcus multilocularis endoplasmin 0.0021 0.0024 0.0049
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0061 0.0098
Onchocerca volvulus 0.0286 0.0875 0.3166
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0022 0.0028 0.0104
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0116 0.033 0.0325
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0055 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0032 0.0083
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.009 0.0146
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.0005 0.0008
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0128 0.0193
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0044 0.0071
Schistosoma mansoni endoplasmin 0.0016 0.0009 0.0004
Loa Loa (eye worm) carboxylesterase 0.0015 0.0006 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0097 0.0243
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0061 0.0221
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0032 0.0083
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0184
Echinococcus multilocularis BC026374 protein (S09 family) 0.0015 0.0006 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0024 0.0149
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.0635 0.2883
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Chlamydia trachomatis cytosol aminopeptidase 0.0683 0.2145 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0055 0.0088
Onchocerca volvulus Matrilysin homolog 0.004 0.0086 0.0295
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0005 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0477 0.1486 0.3932
Trypanosoma brucei heat shock protein 84, putative 0.0021 0.0024 0.0053
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.0635 0.2943
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0012
Plasmodium falciparum importin beta, putative 0.0035 0.0069 0.0097
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.3095 0.819
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0345 0.0339
Toxoplasma gondii heat shock protein 75, putative 0.0021 0.0024 0.0039
Treponema pallidum heat shock protein 90 0.0021 0.0024 0.0343
Toxoplasma gondii hypothetical protein 0.0015 0.0005 0.0008
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0243 0.0735 0.2594
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0055 0.0074
Onchocerca volvulus 0.0015 0.0006 0.0003
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0041 0.0115
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0243 0.0735 0.2594
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0048 0.0347
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.009 0.029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0036 0.0094
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0066 0.0168 0.0431
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0023 0.0031 0.0067
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0021 0.0074
Mycobacterium ulcerans heat shock protein 90 0.0021 0.0024 0.0085
Trypanosoma brucei aminopeptidase, putative 0.0116 0.033 0.1145
Echinococcus granulosus intermediate filament protein 0.0025 0.0038 0.0086
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0069 0.0215
Plasmodium falciparum M17 leucyl aminopeptidase 0.0583 0.1824 0.2942
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0044 0.0071
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Brugia malayi Hsp90 protein 0.0021 0.0024 0.0085
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0243 0.0735 0.1176
Toxoplasma gondii microneme protein MIC17B 0.0015 0.0005 0.0008
Plasmodium falciparum plasmepsin X 0.0023 0.0031 0.0035
Echinococcus multilocularis bloom syndrome protein 0.002 0.0021 0.0041
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Brugia malayi Importin beta-1 subunit 0.0035 0.0069 0.025
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Echinococcus granulosus dna polymerase kappa 0.0023 0.0032 0.0072
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0243 0.0735 0.073
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0061 0.045
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.011
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0009 0.0028
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0116 0.033 0.1197
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0152 0.0446 0.1561
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Echinococcus granulosus leukotriene A 4 hydrolase 0.1192 0.3778 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0683 0.2145 1
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0044 0.0287
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.0635 0.2943
Brugia malayi Thioredoxin reductase 0.0093 0.0255 0.0924
Loa Loa (eye worm) POT family protein 0.0042 0.0093 0.0245
Plasmodium vivax aspartyl protease, putative 0.0023 0.0031 0.0049
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0033 0.0119
Trypanosoma cruzi aminopeptidase, putative 0.0395 0.1223 0.4339
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0339 0.1229
Trypanosoma brucei trypanothione reductase 0.0093 0.0255 0.0878
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0583 0.1824 0.6486
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0318 1
Schistosoma mansoni patched 1 0.0051 0.0121 0.0116
Mycobacterium ulcerans aminopeptidase N PepN 0.0395 0.1223 0.5692
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0339 0.2713
Schistosoma mansoni memapsin-2 (A01 family) 0.0566 0.1771 0.1767
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0339 0.0883
Echinococcus multilocularis neuroligin 0.0015 0.0006 0.0001
Trypanosoma brucei Aminopeptidase M1, putative 0.0395 0.1223 0.4339
Brugia malayi Matrixin family protein 0.0018 0.0016 0.0054
Toxoplasma gondii heat shock protein HSP90 0.0016 0.0009 0.0015
Brugia malayi Pre-SET motif family protein 0.0251 0.0763 0.2771
Schistosoma mansoni ap endonuclease 0.0017 0.0013 0.0008
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0055 0.0089
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0318 0.0829
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Schistosoma mansoni lamin 0.0025 0.0038 0.0032
Brugia malayi Carboxylesterase family protein 0.0089 0.0243 0.088
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Echinococcus granulosus snurportin 1 0.0372 0.1149 0.303
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0021 0.0124
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0131 0.0435
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0016 0.0009 0.001
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0318 0.2545
Trypanosoma cruzi aminopeptidase, putative 0.0243 0.0735 0.2594
Loa Loa (eye worm) hypothetical protein 0.0125 0.0358 0.0945
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0055 0.8921
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0395 0.1223 0.3229
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0005 0.0000000076064
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0013 0.0063
Loa Loa (eye worm) glutathione reductase 0.0093 0.0255 0.0673
Loa Loa (eye worm) hypothetical protein 0.0243 0.0735 0.1945
Leishmania major hypothetical protein, conserved 0.0053 0.0128 0.0425
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Echinococcus granulosus lamin dm0 0.0025 0.0038 0.0086
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0013 0.0063
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0243 0.0735 0.5989
Echinococcus granulosus BC026374 protein S09 family 0.0015 0.0006 0.0001
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Brugia malayi hypothetical protein 0.0243 0.0735 0.267
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0061 0.0097
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0022 0.0028 0.01
Schistosoma mansoni hypothetical protein 0.0125 0.0358 0.0352
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0061 0.0184
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0395 0.1223 0.4339
Echinococcus granulosus inhibitor of apoptosis protein 0.0125 0.0358 0.0933
Leishmania major heat shock protein, putative 0.0021 0.0024 0.0053
Plasmodium vivax endoplasmin, putative 0.0016 0.0009 0.0014
Giardia lamblia DINP protein human, muc B family 0.0023 0.0032 0.45
Trichomonas vaginalis heat shock protein, putative 0.0021 0.0024 0.0149
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0061 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Toxoplasma gondii microneme protein MIC4 0.0015 0.0005 0.0008
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0069 0.0182
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0108
Onchocerca volvulus 0.0025 0.0038 0.0119
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0395 0.1223 0.4339
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0061 0.0097
Schistosoma mansoni flap endonuclease-1 0.0024 0.0036 0.003
Schistosoma mansoni hypothetical protein 0.0048 0.0111 0.0106
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0005 0.000000020152
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0318 0.0313
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0121 0.0319
Loa Loa (eye worm) hypothetical protein 0.0119 0.0339 0.0895
Schistosoma mansoni inhibitor of apoptosis protein 0.0125 0.0358 0.0352
Schistosoma mansoni endoplasmin 0.0016 0.0009 0.0004
Plasmodium vivax aspartyl protease, putative 0.0023 0.0031 0.0049
Trypanosoma brucei unspecified product 0.0023 0.0032 0.0083
Brugia malayi Peptidase family M1 containing protein 0.0395 0.1223 0.4445
Treponema pallidum NADH oxidase 0.0032 0.0061 0.1548
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0395 0.1223 0.3229
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0116 0.033 0.086
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0015 0.0006 0.0001
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0128 0.0325
Brugia malayi intermediate filament protein 0.0025 0.0038 0.0135
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0243 0.0735 0.2594
Mycobacterium leprae PROBABLE HYDROLASE 0.0022 0.0028 0.002
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0021 0.0024 0.0049
Echinococcus multilocularis acetylcholinesterase 0.0089 0.0243 0.0629
Echinococcus granulosus carboxylesterase 5A 0.0089 0.0243 0.0629
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.009 0.0225
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.0711 0.3239
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0125 0.0358 0.1298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0048 0.0347
Echinococcus granulosus flap endonuclease 1 0.0027 0.0044 0.0103
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0023 0.0031 0.0067
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0041 0.0067
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0013 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0089 0.0243 0.0641
Echinococcus granulosus caspase 2 0.0095 0.0262 0.068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0013 0.0021
Mycobacterium ulcerans aminopeptidase N PepN 0.0243 0.0735 0.3409
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0121 0.0947
Schistosoma mansoni lamin 0.0025 0.0038 0.0032
Toxoplasma gondii aspartyl protease ASP1 0.0023 0.0031 0.0049
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0318 0.1104
Brugia malayi Flap endonuclease-1 0.0027 0.0044 0.0158
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0069 0.0112
Brugia malayi Kringle domain containing protein 0.0053 0.0128 0.0464
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0032 0.0027
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0013 0.0021
Brugia malayi RNA, U transporter 1 0.0099 0.0275 0.0997
Toxoplasma gondii aminopeptidase N protein 0.1942 0.618 1
Brugia malayi hypothetical protein 0.0023 0.0031 0.0109
Schistosoma mansoni hypothetical protein 0.0043 0.0097 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0013 0.0015
Onchocerca volvulus 0.0125 0.0358 0.1284
Echinococcus granulosus apoptotic protease activating factor 1 0.0095 0.0262 0.068
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0023 0.0031 0.0079
Loa Loa (eye worm) hypothetical protein 0.0328 0.101 0.2672
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0318 0.0313
Leishmania major trypanothione reductase 0.0093 0.0255 0.0877
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Plasmodium vivax glutathione reductase, putative 0.0093 0.0255 0.0412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0012
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0021 0.0024 0.0085
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0128 0.0207
Brugia malayi Endoplasmin precursor 0.0016 0.0009 0.0032
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0116 0.033 0.0871
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0128 0.0207
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0013 0.0015
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0013 0.0828
Brugia malayi 6-phosphofructokinase 0.0113 0.0318 0.1155
Loa Loa (eye worm) hypothetical protein 0.0089 0.0243 0.0641
Brugia malayi TATA binding protein associated factor 0.0243 0.0735 0.267
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Brugia malayi heat shock protein 90 0.0016 0.0009 0.0032
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0032 0.0072
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0023 0.0031 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0061 0.0184
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0061 0.0256
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0318 0.0841
Loa Loa (eye worm) carboxylesterase 0.0015 0.0006 0.0014
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0395 0.1223 0.4339
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Trypanosoma cruzi Aminopeptidase M1, putative 0.0395 0.1223 0.4339
Onchocerca volvulus 0.0872 0.2752 1
Plasmodium falciparum plasmepsin III 0.0023 0.0031 0.0035
Loa Loa (eye worm) carboxylesterase 0.0089 0.0243 0.0641
Onchocerca volvulus 0.0023 0.0031 0.0093
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0021 0.0024 0.0049
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0502 0.1317
Brugia malayi aspartic protease BmAsp-2, identical 0.0023 0.0031 0.0109
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0128 0.0338
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0395 0.1223 1
Onchocerca volvulus 0.006 0.0149 0.0525
Brugia malayi Hemopexin family protein 0.0026 0.004 0.0142
Onchocerca volvulus Matrilysin homolog 0.0018 0.0016 0.0039
Loa Loa (eye worm) hypothetical protein 0.0062 0.0158 0.0417
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.009 0.029
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0032 0.0191
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0032 0.0124
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0318 0.0829
Echinococcus multilocularis heat shock protein 0.0016 0.0009 0.001
Echinococcus granulosus heat shock protein 90 0.0016 0.0009 0.001
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2628 0.6951
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.011
Loa Loa (eye worm) hypothetical protein 0.0243 0.0735 0.1945
Trypanosoma cruzi Cysteine peptidase, Clan CF, family C15 0.089 0.2808 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0023 0.0031 0.0203
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0061 0.0027
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0038 0.0135
Onchocerca volvulus 0.0015 0.0006 0.0003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0318 0.1387
Brugia malayi Carboxylesterase family protein 0.0089 0.0243 0.088
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.009 0.0132
Brugia malayi hypothetical protein 0.0015 0.0006 0.0019
Toxoplasma gondii microneme protein MIC17C 0.0015 0.0005 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0318 0.2565
Schistosoma mansoni heat shock protein 0.0021 0.0024 0.0019
Entamoeba histolytica hypothetical protein 0.0043 0.0097 0.0722
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.0255 0.0661
Echinococcus multilocularis musashi 0.0025 0.0038 0.0086
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Brugia malayi Matrixin family protein 0.0018 0.0016 0.0054
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0009 0.0028
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Loa Loa (eye worm) hypothetical protein 0.0095 0.0262 0.0692
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0021 0.0024 0.0121
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0061 0.0256
Onchocerca volvulus 0.0243 0.0735 0.2658
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0125
Toxoplasma gondii Hsp90 domain-containing protein 0.0194 0.0578 0.0935
Echinococcus granulosus importin subunit beta 1 0.0035 0.0069 0.0169
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0125 0.0358 0.1298
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0009 0.0028
Echinococcus granulosus lamin 0.0025 0.0038 0.0086
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Brugia malayi CHE-14 protein 0.0051 0.0121 0.0438
Echinococcus multilocularis expressed conserved protein 0.0043 0.0097 0.0242
Loa Loa (eye worm) acetylcholinesterase 1 0.0089 0.0243 0.0641
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0318 0.1104
Echinococcus granulosus leucine aminopeptidase protein 0.0683 0.2145 0.5672
Brugia malayi Carboxylesterase family protein 0.0015 0.0006 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0038 0.0098
Schistosoma mansoni cathepsin D (A01 family) 0.0023 0.0031 0.0025
Loa Loa (eye worm) RecQ helicase 0.002 0.0021 0.0054
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0079 0.0251
Brugia malayi Eukaryotic aspartyl protease family protein 0.0023 0.0031 0.0109
Brugia malayi 6-phosphofructokinase 0.0113 0.0318 0.1155
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0055 0.0088
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Schistosoma mansoni heat shock protein 0.0016 0.0009 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0061 0.0083
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0395 0.1223 0.4339
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0005 0.0018
Entamoeba histolytica hypothetical protein 0.0043 0.0097 0.0722
Echinococcus granulosus leucyl aminopeptidase 0.0116 0.033 0.086
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1192 0.3778 0.3775
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0125 0.0358 0.0352
Leishmania major importin beta-1 subunit, putative 0.0028 0.0048 0.0139
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0015 0.0006 0.0001
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0012
Mycobacterium ulcerans hydrolase 0.0022 0.0028 0.0104
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0683 0.2145 0.347
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Schistosoma mansoni aminopeptidase A (M01 family) 0.0243 0.0735 0.073
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Brugia malayi Carboxylesterase family protein 0.0015 0.0006 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0318 0.2565
Loa Loa (eye worm) hypothetical protein 0.0125 0.0358 0.0945
Toxoplasma gondii aspartyl protease ASP3 0.0023 0.0031 0.0049
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.009 0.0146
Trichomonas vaginalis endoplasmin, putative 0.0016 0.0009 0.0028
Onchocerca volvulus 0.0026 0.004 0.0127
Toxoplasma gondii microneme protein, putative 0.0015 0.0005 0.0008
Brugia malayi Cell death protein 3 precursor 0.0095 0.0262 0.0951
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0069 0.0169
Plasmodium vivax importin-beta 2, putative 0.0035 0.0069 0.0111
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0069 0.0215
Toxoplasma gondii aminopeptidase N, putative 0.1942 0.618 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0149 0.0144
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0121 0.0307
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0243 0.0735 0.1934
Trypanosoma cruzi pyroglutamyl-peptidase I, putative 0.089 0.2808 1
Leishmania major pyroglutamyl-peptidase I (C15 family) 0.089 0.2808 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.0316 0.0822
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0044 0.0103
Leishmania major hypothetical protein, conserved 0.0041 0.009 0.029
Echinococcus granulosus leucyl aminopeptidase 0.0116 0.033 0.086
Schistosoma mansoni cathepsin D (A01 family) 0.0023 0.0031 0.0025
Echinococcus multilocularis heat shock protein 90 0.0016 0.0009 0.001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.009 0.029
Loa Loa (eye worm) hypothetical protein 0.0629 0.1974 0.5225
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0073 0.018
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.0255 0.0412
Loa Loa (eye worm) TATA binding protein associated factor 0.0243 0.0735 0.1945
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0095 0.0262 0.0692
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0318 0.146
Brugia malayi Death domain containing protein 0.0015 0.0005 0.0018
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0043 0.0095 0.009
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1192 0.3778 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0013 0.0015
Onchocerca volvulus 0.0095 0.0262 0.0936
Schistosoma mansoni ap endonuclease 0.0017 0.0013 0.0008
Echinococcus multilocularis dna polymerase eta 0.0054 0.0131 0.0333
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.0255 0.0661
Brugia malayi Carboxylesterase family protein 0.0015 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0152 0.0446 0.1179
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0013 0.0036
Onchocerca volvulus 0.0036 0.0073 0.0249
Brugia malayi Matrixin family protein 0.0018 0.0016 0.0054
Schistosoma mansoni importin beta-1 0.0035 0.0069 0.0064
Loa Loa (eye worm) heat shock protein 75 0.0021 0.0024 0.0062
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Plasmodium falciparum plasmepsin IV 0.0023 0.0031 0.0035
Loa Loa (eye worm) heat shock protein 90 0.0016 0.0009 0.0023
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.0711 0.3296
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0013 0.0036
Brugia malayi hypothetical protein 0.0126 0.0361 0.1312
Echinococcus multilocularis carboxylesterase 5A 0.0089 0.0243 0.0629
Entamoeba histolytica aminopeptidase, putative 0.0395 0.1223 1
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0031 0.0079
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0055 0.0404
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0128 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0032 0.0124
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Brugia malayi hypothetical protein 0.0833 0.2627 0.9549
Entamoeba histolytica hypothetical protein 0.0043 0.0097 0.0722
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0128 0.0325
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0021 0.0024 0.0053
Echinococcus granulosus heat shock protein 0.0016 0.0009 0.001
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0061 0.045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.0068
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0318 0.2545
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0061 0.0184
Plasmodium vivax heat shock protein, putative 0.0194 0.0578 0.0935
Brugia malayi Peptidase family M1 containing protein 0.0872 0.2752 1
Echinococcus multilocularis leucine aminopeptidase protein 0.0683 0.2145 0.5672
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0014
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0041 0.0066
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0021 0.0024 0.0049
Echinococcus granulosus acetylcholinesterase 0.0089 0.0243 0.0629
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0041 0.0052
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0061 0.0218
Mycobacterium tuberculosis Probable reductase 0.0212 0.0635 0.2943
Toxoplasma gondii exonuclease III APE 0.0017 0.0013 0.0022
Leishmania major DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Brugia malayi hypothetical protein 0.0095 0.0262 0.0951
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0055 0.0404
Brugia malayi phosphofructokinase 0.0113 0.0318 0.1155
Onchocerca volvulus 0.0015 0.0006 0.0003
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Toxoplasma gondii thioredoxin reductase 0.0093 0.0255 0.0412
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0152 0.0446 0.1168
Brugia malayi Protein kinase domain containing protein 0.0015 0.0005 0.0018
Brugia malayi hypothetical protein 0.0026 0.0041 0.0148
Loa Loa (eye worm) peptidase family M1 containing protein 0.072 0.2263 0.599
Onchocerca volvulus Cell death protein 3 homolog 0.0095 0.0262 0.0936
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.009 0.0225
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.004
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0243 0.0735 0.2594
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0097 0.0243
Echinococcus granulosus acetylcholinesterase 0.0089 0.0243 0.0629
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0033 0.0119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0184
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.0255 0.1164
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.009 0.029
Giardia lamblia Grp94/Hsp90 0.0021 0.0024 0.2863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0061 0.0221
Loa Loa (eye worm) hypothetical protein 0.006 0.0149 0.0393
Trypanosoma brucei pyroglutamyl-peptidase I, putative 0.089 0.2808 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0055
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0116 0.033 0.1145
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0125 0.0358 0.0933
Leishmania major DNA polymerase eta, putative 0.0038 0.0079 0.0251
Plasmodium falciparum flap endonuclease 1 0.0027 0.0044 0.0056
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0073 0.018
Toxoplasma gondii PAN domain-containing protein 0.0015 0.0005 0.0008
Brugia malayi hypothetical protein 0.0395 0.1223 0.4445
Brugia malayi cytosol aminopeptidase 0.0116 0.033 0.1197
Loa Loa (eye worm) matrix metalloproteinase 0.0018 0.0016 0.004
Echinococcus granulosus endoplasmin 0.0021 0.0024 0.0049
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0152 0.0446 0.0441
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0055 0.0089
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.057 0.1784 0.1779
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Echinococcus multilocularis inhibitor of apoptosis protein 0.0125 0.0358 0.0933
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Plasmodium falciparum glutathione reductase 0.0032 0.0061 0.0083
Plasmodium vivax aspartyl proteinase, putative 0.0023 0.0031 0.0049
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0023 0.0031 0.0049
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0055 0.0089
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0061 0.0184
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Plasmodium vivax plasmepsin V, putative 0.0023 0.0031 0.0049
Echinococcus multilocularis acetylcholinesterase 0.0089 0.0243 0.0629
Loa Loa (eye worm) hypothetical protein 0.0022 0.0028 0.0073
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0038 0.0098
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0683 0.2145 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0013 0.0035
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0044 0.0125
Loa Loa (eye worm) hypothetical protein 0.0054 0.0131 0.0345
Echinococcus granulosus expressed conserved protein 0.0043 0.0097 0.0242
Plasmodium falciparum plasmepsin VII 0.0023 0.0031 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0073 0.0068
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0583 0.1824 0.6486
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0041 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0041 0.0052
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0318 0.2565
Echinococcus granulosus dna polymerase eta 0.0054 0.0131 0.0333
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0339 0.0883
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0032 0.0072
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0318 0.146
Echinococcus multilocularis protein patched 0.0051 0.0121 0.0307
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0079
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.1942 0.618 1
Schistosoma mansoni leucine aminopeptidase 0.0116 0.033 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0032 0.0083
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0061 0.0184
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0061 0.0184
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0243 0.0735 0.2594
Echinococcus multilocularis para nitrobenzyl esterase 0.0015 0.0006 0.0001
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0131 0.0435
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0044 0.0115
Loa Loa (eye worm) matrixin family protein 0.0044 0.0098 0.0257
Schistosoma mansoni hypothetical protein 0.0049 0.0115 0.011
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0031 0.0025
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0061 0.0146
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0032 0.0124
Brugia malayi Protein kinase domain containing protein 0.0053 0.0128 0.0464
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0044 0.0314
Schistosoma mansoni intermediate filament proteins 0.0025 0.0038 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0031 0.0079
Brugia malayi Carboxylesterase family protein 0.0015 0.0006 0.0019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0192
Schistosoma mansoni hypothetical protein 0.0095 0.0262 0.0257
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0116 0.033 0.1197
Plasmodium falciparum heat shock protein 90, putative 0.0194 0.0578 0.0922
Toxoplasma gondii heat shock protein 90, putative 0.0016 0.0009 0.0015
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0073 0.018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0032 0.0072
Plasmodium falciparum plasmepsin II 0.0023 0.0031 0.0035
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0008 0.0002
Trypanosoma brucei Aminopeptidase M1, putative 0.0395 0.1223 0.4339
Plasmodium falciparum M1-family alanyl aminopeptidase 0.1942 0.618 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.0711 0.3296
Brugia malayi hypothetical protein 0.0043 0.0097 0.035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0012
Plasmodium falciparum plasmepsin V 0.0023 0.0031 0.0035
Echinococcus granulosus para nitrobenzyl esterase 0.0015 0.0006 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0013 0.0015
Brugia malayi PAN domain containing protein 0.0015 0.0005 0.0016
Toxoplasma gondii microneme protein MIC17A 0.0015 0.0005 0.0008
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0243 0.0735 0.1189
Echinococcus multilocularis leucyl aminopeptidase 0.0116 0.033 0.086
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.042 0.1109
Trichomonas vaginalis set domain proteins, putative 0.0286 0.0874 0.7131
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0098
Plasmodium falciparum plasmepsin IX 0.0023 0.0031 0.0035
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.009 0.0146
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0069 0.0168
Loa Loa (eye worm) hypothetical protein 0.0053 0.0128 0.0338
Onchocerca volvulus 0.0018 0.0016 0.0039
Onchocerca volvulus Deterin homolog 0.0125 0.0358 0.1284
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0044 0.6777
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0032 0.0124
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1192 0.3778 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0446 0.1179
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0066 0.0168 0.0431

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.145 uM PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596] ChEMBL. No reference
AC50 (binding) = 1.992 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
IC50 (binding) = 17.1 uM PUBCHEM_BIOASSAY: uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1991, AID434967] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 70.7946 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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