Detailed information for compound 1876046

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.46 | Formula: C19H25N9O3
  • H donors: 3 H acceptors: 6 LogP: 2.07 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(c(c1)O)/C=N/NC(=O)c1nnn(c1C(C)C)c1nonc1N)CC
  • InChi: 1S/C19H25N9O3/c1-5-27(6-2)13-8-7-12(14(29)9-13)10-21-23-19(30)15-16(11(3)4)28(26-22-15)18-17(20)24-31-25-18/h7-11,29H,5-6H2,1-4H3,(H2,20,24)(H,23,30)/b21-10+
  • InChiKey: YBCYSQRWBTYEHT-UFFVCSGVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Candida albicans hypothetical protein Starlite/ChEMBL No references
Homo sapiens alkaline phosphatase, liver/bone/kidney Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens alkaline phosphatase, intestinal Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis intestinal type alkaline phosphatase 1 Get druggable targets OG5_126976 All targets in OG5_126976
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Alkaline phosphatase, tissue-nonspecific isozyme precursor, putative Get druggable targets OG5_126976 All targets in OG5_126976
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans vacuolar alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus intestinal type alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans alkaline phosphatase Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus alkaline phosphatase intestinal gene 2 Get druggable targets OG5_126976 All targets in OG5_126976
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K01077 alkaline phosphatase [EC3.1.3.1], putative Get druggable targets OG5_126976 All targets in OG5_126976
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni hypothetical protein Get druggable targets OG5_126976 All targets in OG5_126976
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.043 0.0421
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0158 0.0149
Schistosoma mansoni pyruvate dehydrogenase 0.0008 0.0049 0.004
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0158 0.1071
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0583 0.8871
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0326
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0158 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0583 0.8871
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0857 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0336 0.3547
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0243 0.2832
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0158 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0158 0.1071
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0336 0.3547
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0152 0.0143
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0336 0.0906
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0008 0.006 0.014
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.006 0.0486
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0158 0.0413
Schistosoma mansoni alkaline phosphatase 0.0393 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0158 0.1071
Brugia malayi isocitrate dehydrogenase 0.0019 0.0336 0.235
Loa Loa (eye worm) hypothetical protein 0.0029 0.0583 0.159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0008 0.0049 0.0315
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1399 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.043 0.4709
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0158 0.0149
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0583 0.8907
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0336 0.3915
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0158 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0158 0.1071
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.043 0.4709
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0152 0.1027
Plasmodium vivax heat shock protein 90, putative 0.0016 0.0258 0.2588
Onchocerca volvulus 0.0012 0.0158 0.2041
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.006 0.0486
Schistosoma mansoni ap endonuclease 0.0023 0.043 0.0421
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Mycobacterium ulcerans hypothetical protein 0.0029 0.0583 0.8871
Onchocerca volvulus 0.0029 0.0583 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0907 0.2488
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0336 0.3547
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0008 0.006 0.0177
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.006 0.0132
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0158 0.2041
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0396 1
Trypanosoma cruzi heat shock protein 90, putative 0.0023 0.0441 0.4855
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0158 0.1071
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0008 0.0049 0.004
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0583 0.4127
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0583 0.8871
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0651 0.7443
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0158 0.2041
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0336 0.0327
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0008 0.0049 0.0315
Schistosoma mansoni hypothetical protein 0.0204 0.512 0.5116
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0008 0.0049 0.0315
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0857 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0335 0.0326
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0243 0.2397
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0393 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.043 0.4709
Echinococcus granulosus GPCR family 2 0.0019 0.0335 0.0326
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0008 0.006 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0158 0.1071
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0857 0.2352
Loa Loa (eye worm) hypothetical protein 0.0021 0.0396 0.1072
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Schistosoma mansoni hypothetical protein 0.0205 0.5134 0.513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0396 0.1072
Echinococcus multilocularis heat shock protein 0.0039 0.0857 0.0849
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0326
Echinococcus multilocularis endoplasmin 0.0031 0.0651 0.0642
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.006 0.0051
Schistosoma mansoni alkaline phosphatase 0.0393 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0335 0.0326
Schistosoma mansoni ap endonuclease 0.0023 0.043 0.0421
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0335 0.0903
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0008 0.0049 0.0571
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0335 0.0903
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0335 0.2344
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0008 0.006 0.0177
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0158 0.0149
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0336 0.0327
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0365 0.5407
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0158 0.0149
Plasmodium falciparum heat shock protein 90 0.0039 0.0857 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0031 0.0651 1
Echinococcus multilocularis heat shock protein 90 0.0031 0.0651 0.0642
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0152 0.0143
Plasmodium falciparum endoplasmin, putative 0.0024 0.0465 0.5145
Trichomonas vaginalis heat shock protein, putative 0.0024 0.0465 0.5145
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0583 0.6602
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0008 0.0049 0.004
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0158 0.0149
Loa Loa (eye worm) endoplasmin 0.0039 0.0857 0.2352
Trypanosoma brucei heat shock protein 84, putative 0.0016 0.0258 0.2588
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0583 0.8871
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0158 0.0149
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0857 1
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0583 0.6602
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0152 0.0143
Onchocerca volvulus 0.0008 0.006 0.02
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.006 0.0486
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0031 0.0651 0.0642
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0158 0.0149
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Loa Loa (eye worm) RecQ helicase 0.0029 0.0592 0.1616
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Loa Loa (eye worm) hypothetical protein 0.0008 0.006 0.014
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0857 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0008 0.0049 0.0315
Loa Loa (eye worm) TOPoisomerase family member 0.0008 0.0049 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0158 0.0149
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0158 0.0149
Mycobacterium ulcerans heat shock protein 90 0.0031 0.0651 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0008 0.0049 0.0571
Schistosoma mansoni DNA helicase recq1 0.0012 0.0152 0.0143
Plasmodium vivax heat shock protein, putative 0.0016 0.0258 0.2588
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0393 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0158 0.1071
Echinococcus granulosus endoplasmin 0.0031 0.0651 0.0642
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0008 0.0049 0.004
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0857 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0592 0.6717
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0008 0.0049 0.0315
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0651 0.7443
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0583 0.6796
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.043 0.6327
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0336 0.493
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0008 0.0049 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.043 0.3026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0158 0.1071
Schistosoma mansoni endoplasmin 0.0039 0.0857 0.0849
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0857 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0008 0.006 0.0177
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0243 0.2397
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0158 0.0149
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0583 0.8871
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0365 0.5407
Brugia malayi Probable DNA topoisomerase II 0.0008 0.0049 0.0288
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0158 0.0149
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0336 0.3547
Onchocerca volvulus 0.0008 0.006 0.02
Echinococcus multilocularis heat shock protein 90 0.0039 0.0857 0.0849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0335 0.0326
Echinococcus granulosus heat shock protein 90 0.0031 0.0651 0.0642
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.043 0.1166
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.006 0.0696
Mycobacterium ulcerans acetyl-CoA synthetase 0.0008 0.006 0.0177
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0258 0.2588
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0365 0.5407
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0651 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0158 0.0149
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0158 0.1071
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.006 0.0051
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.043 0.4709
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.043 0.6327
Loa Loa (eye worm) hypothetical protein 0.0146 0.3616 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0336 0.235
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0583 0.4127
Trichomonas vaginalis heat shock protein, putative 0.0016 0.0258 0.2588
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0008 0.0049 0.0315
Loa Loa (eye worm) hypothetical protein 0.0021 0.0396 0.1072
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0158 0.0149
Schistosoma mansoni heat shock protein 0.0039 0.0857 0.0849
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.043 0.4709
Echinococcus granulosus heat shock protein 0.0039 0.0857 0.0849
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0008 0.006 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0907 0.6456
Echinococcus granulosus alkaline phosphatase 0.0393 1 1
Schistosoma mansoni heat shock protein 0.0016 0.0258 0.0249
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0857 1
Echinococcus multilocularis alkaline phosphatase 0.0393 1 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0336 0.3547
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0008 0.0049 0.0315
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0158 0.0149
Treponema pallidum heat shock protein 90 0.0031 0.0651 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0396 0.4287
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0008 0.0049 0.0288
Brugia malayi kinase, mitochondrial precursor 0.0008 0.0049 0.0288
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0857 1
Brugia malayi Hsp90 protein 0.0016 0.0258 0.1793
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0016 0.0258 0.0249
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.006 0.0486
Loa Loa (eye worm) hypothetical protein 0.0029 0.0583 0.159
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0365 0.5407
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.006 0.0486
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0857 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0158 0.0149
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.006 0.0486
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.043 0.0421
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0152 0.0143
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.043 0.5011
Toxoplasma gondii DNA topoisomerase 2, putative 0.0008 0.0049 0.0571
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0016 0.0258 0.3012
Brugia malayi AMP-binding enzyme family protein 0.0008 0.006 0.0364
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.006 0.0696
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Probable two component sensor kinase 0.0008 0.0049 0.0315
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0583 0.8907
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.043 0.4709
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0336 0.3547
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.006 0.0486
Schistosoma mansoni DNA topoisomerase II 0.0008 0.0049 0.004
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0152 0.1271
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0158 0.1071
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0031 0.0651 0.7443
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0008 0.0049 0.0315
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0158 0.2041
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0592 0.6717
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0158 0.0149
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0152 0.1271
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0583 0.8871
Brugia malayi Endoplasmin precursor 0.0039 0.0857 0.6103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0158 0.1071
Onchocerca volvulus 0.0008 0.006 0.02
Brugia malayi AMP-binding enzyme family protein 0.0008 0.006 0.0364
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0583 0.8871
Schistosoma mansoni heat shock protein 0.0039 0.0857 0.0849
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0158 0.0149
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.006 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0583 0.8871
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.006 0.0132
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0158 0.1071
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0396 0.5893
Schistosoma mansoni endoplasmin 0.0039 0.0857 0.0849
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0336 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0158 0.0413
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0008 0.0049 0.0315
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0336 0.3547
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0343 0.4003
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0008 0.006 0.0177
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Brugia malayi ecdysteroid receptor 0.0012 0.0158 0.1071
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.006 0.0486
Brugia malayi nuclear receptor NHR-88 0.0012 0.0158 0.1071
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0152 0.0396
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0349 0.3714
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0158 0.1071
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.043 0.4709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.006 0.0486
Trypanosoma cruzi heat shock protein, putative 0.0016 0.0258 0.2588
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0857 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0158 0.0149
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0008 0.006 0.0177
Giardia lamblia Grp94/Hsp90 0.0031 0.0651 0.7443
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.006 0.014
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0335 0.2344
Brugia malayi heat shock protein 90 0.0039 0.0857 0.6103
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0008 0.006 0.0177
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0592 0.0583
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0152 0.1027
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0008 0.0049 0.004
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0583 0.4127
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.006 0.0132
Plasmodium vivax endoplasmin, putative 0.0039 0.0857 1
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0396 0.1072
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0152 0.177
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0008 0.0049 0.0288
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1399 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0158 0.0149
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0336 0.0327
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0158 0.0149
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0396
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.043 0.4709
Trichomonas vaginalis endoplasmin, putative 0.0024 0.0465 0.5145
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0016 0.0258 0.392
Loa Loa (eye worm) hypothetical protein 0.006 0.1399 0.3854
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0393 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.5134 0.513
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0396 0.4287
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0857 1
Schistosoma mansoni hypothetical protein 0.0019 0.0335 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Leishmania major heat shock protein, putative 0.0016 0.0258 0.2588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0158 0.0413
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0008 0.0049 0.0315
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0158 0.0149
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0336 0.3915
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0152 0.177
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.043 0.4709
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0335 0.0326
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0158 0.0149
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0434 0.0426
Loa Loa (eye worm) hypothetical protein 0.0021 0.0396 0.1072
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0008 0.0049 0.0315
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0651 0.7443
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0393 1 1
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.006 0.0486
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0008 0.006 0.0177
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0336 0.0327
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0158 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0008 0.006 0.0364
Brugia malayi nuclear hormone receptor 0.0012 0.0158 0.1071
Echinococcus multilocularis geminin 0.0205 0.5134 0.513
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0243 0.2397
Loa Loa (eye worm) oxidoreductase 0.0008 0.006 0.014
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.006 0.0364
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0592 0.4194
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0158 0.0413
Loa Loa (eye worm) hypothetical protein 0.0008 0.0049 0.0111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0857 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0336 0.0327
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0857 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0651 0.7443
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0158 0.0149
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0501 0.5591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0158 0.0413
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0583 0.6602
Giardia lamblia Heat shock protein HSP 90-alpha 0.0031 0.0651 0.7443
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.006 0.0132
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0158 0.0149
Toxoplasma gondii Hsp90 domain-containing protein 0.0016 0.0258 0.3012
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0008 0.0049 0.0571
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0583 0.8871
Echinococcus granulosus bloom syndrome protein 0.0029 0.0592 0.0583
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.006 0.0132
Toxoplasma gondii heat shock protein 75, putative 0.0016 0.0258 0.3012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0583 0.6796
Toxoplasma gondii exonuclease III APE 0.0023 0.043 0.5011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1399 0.3854
Brugia malayi AMP-binding enzyme family protein 0.0008 0.006 0.0364
Brugia malayi steroid hormone receptor 0.0012 0.0158 0.1071
Mycobacterium tuberculosis Possible two component sensor kinase 0.0008 0.0049 0.0315
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0651 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0158 0.1071
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0336 0.0327
Loa Loa (eye worm) heat shock protein 75 0.0016 0.0258 0.0691
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.043 0.6327
Trypanosoma brucei heat shock protein, putative 0.0039 0.0857 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0049 0.0111
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Toxoplasma gondii propionate-CoA ligase 0.0008 0.006 0.0696
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0393 1 1
Echinococcus granulosus heat shock protein 90 0.0039 0.0857 0.0849
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0243 0.2397
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0651 0.7443
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0016 0.0258 0.0249
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.006 0.0696
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0008 0.006 0.0177
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.006 0.0364
Leishmania major heat shock protein 83-1 0.0039 0.0857 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.006 0.0132
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0857 1
Schistosoma mansoni coup transcription factor 0.0012 0.0158 0.0149
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0158 0.0149
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0008 0.006 0.0177
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0583 0.6796
Schistosoma mansoni hypothetical protein 0.0041 0.0907 0.0898
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0158 0.0149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0583 0.159
Echinococcus granulosus geminin 0.0205 0.5134 0.513
Echinococcus multilocularis GPCR, family 2 0.0019 0.0335 0.0326
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.043 0.6442
Loa Loa (eye worm) hypothetical protein 0.0008 0.0049 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0158 0.1071
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0396 0.576
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.006 0.014
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0158 0.0149
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.006 0.0486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0158 0.0413
Schistosoma mansoni DNA helicase recq5 0.0012 0.0152 0.0143
Plasmodium falciparum heat shock protein 90, putative 0.0016 0.0258 0.2588
Mycobacterium tuberculosis Conserved protein 0.0008 0.0049 0.0315
Entamoeba histolytica DNA topoisomerase II, putative 0.0008 0.0049 0.0571
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0857 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0008 0.006 0.0177
Onchocerca volvulus 0.0008 0.006 0.02
Loa Loa (eye worm) hypothetical protein 0.0012 0.0158 0.0413

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.199 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1554, AID1674] ChEMBL. No reference
EC50 (functional) = 0.472 uM PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] ChEMBL. No reference
EC50 (functional) = 2.83 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 6.055 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 7.396 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 10.5 uM PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] ChEMBL. No reference
EC50 (functional) = 19 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] ChEMBL. No reference
EC50 (functional) 20.6 uM PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] ChEMBL. No reference
EC50 (functional) = 73.7 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] ChEMBL. No reference
IC50 (functional) = 78 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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