Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific demethylase 4A | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | PHD finger protein 15 | 0.0035 | 0.1543 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.0049 | 0.2999 | 0.2999 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.2568 | 0.3426 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2407 | 0.2407 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3658 | 0.4878 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.1845 | 0.0937 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2718 | 0.3972 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.07 | 0.07 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1543 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1543 | 0.2058 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0035 | 0.1543 | 0.1543 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.302 | 0.4413 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0045 | 0.2568 | 0.3426 |
Echinococcus multilocularis | peregrin | 0.0038 | 0.1845 | 0.1845 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1543 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3658 | 0.4878 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0115 | 1 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0035 | 0.1543 | 0.1543 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2709 | 0.1897 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3658 | 0.5346 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0045 | 0.2568 | 0.3754 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0078 | 0.0114 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3658 | 0.3658 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0049 | 0.2999 | 0.2999 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.07 | 0.07 |
Echinococcus granulosus | peregrin | 0.0038 | 0.1845 | 0.1845 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0322 | 0.0429 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3658 | 0.3658 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3658 | 0.4878 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1543 | 0.2255 |
Onchocerca volvulus | Alhambra homolog | 0.0035 | 0.1543 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0035 | 0.1543 | 0.2255 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0043 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0456 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.4198 | 0.6136 |
Brugia malayi | jmjC domain containing protein | 0.0045 | 0.2568 | 0.1741 |
Schistosoma mansoni | jumonji domain containing protein | 0.0092 | 0.7498 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3658 | 0.3658 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0045 | 0.2568 | 0.2568 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3658 | 0.3658 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2407 | 0.2407 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3658 | 0.2952 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0115 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0456 | 0.0609 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0322 | 0.0322 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0035 | 0.1543 | 0.2058 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.5894 | 0.7861 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.5501 | 0.8039 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5437 | 0.5437 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.7388 | 0.7097 |
Brugia malayi | PHD-finger family protein | 0.0035 | 0.1543 | 0.0601 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0322 | 0.0322 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5437 | 0.5437 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.07 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.3263 | 0.4769 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0035 | 0.1543 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0035 | 0.1543 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6843 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.4125 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.