Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4247 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4247 | 1 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0072 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4247 | 1 | 1 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2506 | 0.5831 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4175 | 0.9828 | 0.9828 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0072 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1812 | 0.4169 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.2435 | 0.566 | 0.566 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.4175 | 0.9828 | 0.9828 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.0124 | 0.0124 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.016 | 0.016 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0072 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.2506 | 0.5831 | 1 |
Echinococcus multilocularis | geminin | 0.0139 | 0.016 | 0.016 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4247 | 1 | 1 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0124 | 0.0124 | 1 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4247 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1812 | 0.4169 | 0.4169 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1812 | 0.4169 | 0.4169 |
Echinococcus granulosus | geminin | 0.0139 | 0.016 | 0.016 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0072 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2506 | 0.5831 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4247 | 1 | 1 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0072 | 0 | 0.5 |
Onchocerca volvulus | 0.4247 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1812 | 0.4169 | 0.4169 |
Brugia malayi | MH2 domain containing protein | 0.0098 | 0.0062 | 0.5003 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4175 | 0.9828 | 0.9828 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0098 | 0.0062 | 0.0062 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0072 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0072 | 0 | 0.5 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.4175 | 0.9828 | 0.9828 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2506 | 0.5831 | 1 |
Treponema pallidum | phosphoglyceromutase | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0072 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4247 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0072 | 0 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0072 | 0 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.0124 | 0.0124 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0072 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.016 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.4175 | 0.9828 | 0.9828 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0 | 0.5 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0072 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0072 | 0 | 0.5 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0072 | 0 | 0.5 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0072 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2506 | 0.5831 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0098 | 0.0062 | 0.0062 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 157 % | Increase in the accumulation of vincristine in multi-drug resistant GC3/Cl (human adenocarcinoma) cell line in vitro. | ChEMBL. | 1527786 |
Control (functional) | = 280 % | Increase in the accumulation of vincristine in multi-drug resistant KB8-5 (HeLa variant) cell line in vitro. | ChEMBL. | 1527786 |
Control (functional) | = 280 % | Increase in the accumulation of vincristine in multi-drug resistant KB8-5 (HeLa variant) cell line in vitro. | ChEMBL. | 1527786 |
Control (functional) | = 426 % | Increase in the accumulation of vinblastine in multi-drug resistant GC3/Cl (human adenocarcinoma) cell line in vitro. | ChEMBL. | 1527786 |
Control (functional) | = 776 % | Increase in the accumulation of vinblastine in multi-drug resistant KB8-5 (HeLa variant) cell line in vitro. | ChEMBL. | 1527786 |
Control (functional) | = 776 % | Increase in the accumulation of vinblastine in multi-drug resistant KB8-5 (HeLa variant) cell line in vitro. | ChEMBL. | 1527786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.