Detailed information for compound 1876631

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 531.621 | Formula: C26H33N3O7S
  • H donors: 2 H acceptors: 4 LogP: 4.44 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=C(C(=O)OCC)C=Nc1ccc(c(c1)S(=O)(=O)Nc1ccccc1OC)N1CCCCC1)O
  • InChi: 1S/C26H33N3O7S/c1-4-35-25(30)20(26(31)36-5-2)18-27-19-13-14-22(29-15-9-6-10-16-29)24(17-19)37(32,33)28-21-11-7-8-12-23(21)34-3/h7-8,11-14,17-18,28,30H,4-6,9-10,15-16H2,1-3H3
  • InChiKey: GPUUMUGUAVWSSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens regulator of G-protein signaling 4 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis expressed protein Get druggable targets OG5_141764 All targets in OG5_141764
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.1255 0.5
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0383 0.0255
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0383 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2428 0.2327
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Brugia malayi PXA domain containing protein 0.0023 0.0383 0.1095
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.0383 0.0255
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0392 0.1613
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.1255 0.1138
Echinococcus multilocularis beta adrenergic receptor kinase 0.0024 0.0392 0.0263
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.0383 0.0835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2428 1
Loa Loa (eye worm) RGS-3 protein 0.0023 0.0383 0.0835
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0383 0.1579
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 0.5
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2428 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2428 1
Schistosoma mansoni DNA helicase recq1 0.0012 0.0132 0.0543
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Brugia malayi Probable ClpP-like protease 0.0094 0.1987 0.8077
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.1255 0.5
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 0.5
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.1987 0.1879
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0383 0.0255
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.0383 0.0255
Echinococcus granulosus beta-adrenergic receptor kinase 0.0024 0.0392 0.0263
Brugia malayi hypothetical protein 0.0023 0.0383 0.1095
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0515 0.1667
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0392 0.1613
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0298 0.1502
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0383 0.1579
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0595 0.1728
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1987 1
Entamoeba histolytica hypothetical protein 0.0023 0.0383 0.1579
Toxoplasma gondii hypothetical protein 0.0033 0.0595 0.2993
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.0383 0.1095
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.0383 0.1579
Entamoeba histolytica hypothetical protein 0.0023 0.0383 0.1579
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2428 1
Giardia lamblia Kinase, PLK 0.0114 0.2428 1
Brugia malayi hypothetical protein 0.0023 0.0383 0.1095
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.1987 0.8182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.1987 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0436 0.1637
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 0.5
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.1987 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2428 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0383 0.0255
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2428 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2428 1
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0383 0.0255
Trypanosoma brucei polo-like protein kinase 0.0114 0.2428 1
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0392 0.1613
Loa Loa (eye worm) hypothetical protein 0.0146 0.3145 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.0515 0.1271
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0515 0.0388
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.0383 0.1095
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.0383 0.0255
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0515 0.137
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2428 0.2327
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Brugia malayi PXA domain containing protein 0.0023 0.0383 0.1095
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.0383 0.1579
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0595 0.2494
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.1255 0.1138
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0132 0.0664
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 1
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0383 0.1579
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0383 0.0255
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0383 0.1095
Echinococcus multilocularis expressed protein 0.0451 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Schistosoma mansoni DNA helicase recq5 0.0012 0.0132 0.0543
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0024 0.0392 0.0862
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.1987 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0515 0.137
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.1987 0.1879
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.0383 0.0255
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.1255 0.4744
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0211 0.0869
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.0383 0.0255
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.0383 0.1579
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.0383 0.1095
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.0383 0.0255
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0383 0.1579
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.0383 0.0255
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0024 0.0392 0.0862
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0132 0.0664
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 0.5
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0383 0.1579
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0383 0.1579
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0383 0.0777
Echinococcus granulosus bloom syndrome protein 0.0029 0.0515 0.0388
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0024 0.0392 0.1131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0383 0.0835
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0378 0.1555
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1133 0.4157
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.0383 0.0835
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.0383 0.0255
Entamoeba histolytica hypothetical protein 0.0023 0.0383 0.1579
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.0383 0.0255
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.0383 0.1095
Schistosoma mansoni kinase 0.0058 0.1167 0.4804
Schistosoma mansoni axis inhibition protein axin 0.0023 0.0383 0.1579
Loa Loa (eye worm) hypothetical protein 0.0094 0.1987 0.6156
Echinococcus granulosus axis inhibition protein axin 0.0023 0.0383 0.0255
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0383 0.1579
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.0383 0.0777
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.1987 0.5
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.0383 0.0255
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2428 0.7622
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1133 0.4157
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2428 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 10.6213 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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