Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0796 | 0.2511 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2147 | 0.7253 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2147 | 0.7253 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2147 | 0.7253 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0476 | 0.1502 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0021 | 0.0476 | 0.1607 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0374 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0374 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0374 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2147 | 0.7253 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3852 | 0.3852 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0684 | 0.0684 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2147 | 0.6776 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0476 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0476 | 0.0476 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1714 | 0.1714 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.3169 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0374 | 0.1179 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2147 | 0.6776 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.3603 | 0.3603 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0021 | 0.0476 | 0.1607 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2961 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2961 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2147 | 0.6776 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0796 | 0.2688 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0021 | 0.0476 | 0.1607 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2147 | 0.2147 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0623 | 0.2104 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0623 | 0.2104 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0374 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0934 | 0.0934 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0796 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1967 | 0.1967 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0021 | 0.0476 | 0.1607 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1718 | 0.1718 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1856 | 0.1856 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1576 | 0.5323 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0623 | 0.1965 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0512 | 0.0512 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.0476 | 0.1502 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0684 | 0.216 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1576 | 0.5323 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0374 | 0.1179 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.0476 | 0.1502 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2147 | 0.2147 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.