Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | relaxin/insulin-like family peptide receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0006 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | Basement membrane proteoglycan homolog | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | calcium binding EGF domain-containing protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | Terribly reduced optic lobes homolog | 0.0006 | 0 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor domain class A containing protein | 0.0006 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Onchocerca volvulus | 0.0006 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.0323 uM | PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.