Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.5053 | 0.5051 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0772 | 0.0753 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0644 | 0.0564 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0772 | 0.0265 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0772 | 0.0265 |
Brugia malayi | hypothetical protein | 0.003 | 0.0565 | 0.0485 |
Echinococcus granulosus | lamin | 0.0033 | 0.0644 | 0.0624 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0565 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0772 | 0.0774 |
Onchocerca volvulus | 0.0036 | 0.0772 | 0.0137 | |
Onchocerca volvulus | 0.0058 | 0.1592 | 0.1013 | |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0565 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.1592 | 0.195 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0772 | 0.0753 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1592 | 0.195 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0565 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0644 | 0.0564 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0772 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0644 | 0.0645 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0772 | 0.0265 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0644 | 0.0624 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0565 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0772 | 0.0753 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0644 | 0.0624 |
Brugia malayi | hypothetical protein | 0.0286 | 0.9982 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4763 | 0.4772 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4763 | 0.4772 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0772 | 0.0265 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.5053 | 0.5051 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0772 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4763 | 0.4726 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0644 | 0.0624 |
Brugia malayi | hypothetical protein | 0.002 | 0.0167 | 0.0082 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.0724 | 0.0704 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0644 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.5053 | 0.9073 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0565 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0772 | 0.0694 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.9982 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.5504 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0644 | 0.0645 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0565 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.1592 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0644 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.9982 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0565 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0622 | 0.0623 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.9982 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0086 | 0.0086 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.5504 | 0.5504 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.5504 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.8718 | 0.8723 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.8718 | 0.8734 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0644 | 0.0624 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.4467 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.