TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.46 | Formula: C20H21F2N3O5S
H donors: 1 H acceptors: 3 LogP: 2.75 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: FC(Oc1ccc(cc1)/C(=N/NC(=O)c1cccc(c1)S(=O)(=O)N1CCOCC1)/C)F
InChi: 1S/C20H21F2N3O5S/c1-14(15-5-7-17(8-6-15)30-20(21)22)23-24-19(26)16-3-2-4-18(13-16)31(27,28)25-9-11-29-12-10-25/h2-8,13,20H,9-12H2,1H3,(H,24,26)/b23-14+
InChiKey: PPJVCMCRSKLLKO-OEAKJJBVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	K(lysine) acetyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Bromodomain containing protein, related	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium berghei	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium falciparum	histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Theileria parva	histone acetyltransferase Gcn5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium yoelii	histone acetyltransferase GCN5-related	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	Get druggable targets OG5_127781	All targets in OG5_127781
Babesia bovis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium knowlesi	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Echinococcus granulosus	histone acetyltransferase KAT2B	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Giardia lamblia	Histone acetyltransferase GCN5	Get druggable targets OG5_127781	All targets in OG5_127781
Schistosoma japonicum	ko:K06062 p300/CBP-associated factor, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	Get druggable targets OG5_127781	All targets in OG5_127781
Loa Loa (eye worm)	acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	Get druggable targets OG5_127781	All targets in OG5_127781
Plasmodium vivax	histone acetyltransferase GCN5, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium hominis	histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Trichomonas vaginalis	bromodomain-containing protein, putative	Get druggable targets OG5_127781	All targets in OG5_127781
Candida albicans	bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase	Get druggable targets OG5_127781	All targets in OG5_127781
Entamoeba histolytica	acetyltransferase, GNAT family	Get druggable targets OG5_127781	All targets in OG5_127781
Cryptosporidium parvum	GCN5 like acetylase + bromodomain	Get druggable targets OG5_127781	All targets in OG5_127781
Brugia malayi	acetyltransferase, GNAT family protein	Get druggable targets OG5_127781	All targets in OG5_127781
Neospora caninum	hypothetical protein	Get druggable targets OG5_127781	All targets in OG5_127781

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0038	0.0079
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.32	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1604	0.3382
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0707	0.149
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0182	0.4972	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0154	0.4089	0.4066
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.32	0.7806
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0059	0.1192	0.2338
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0044	0.0724	0.1527
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0164	0.4404	0.4383
Plasmodium falciparum	SUMO-activating enzyme subunit 2	0.0036	0.0492	0.4589
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0085	0.1997	0.421
Leishmania major	DNA polymerase eta, putative	0.0125	0.3208	0.3182
Schistosoma mansoni	lipoxygenase	0.0122	0.3108	0.6553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0034	0.0409	0.3242
Leishmania major	ATP-dependent phosphofructokinase	0.0125	0.32	0.3174
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0059	0.1197	0.1163
Trypanosoma brucei	unspecified product	0.0066	0.1401	0.1368
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0036	0.0492	0.1037
Brugia malayi	phosphofructokinase	0.0125	0.32	0.6746
Trypanosoma brucei	DNA damage repair protein, putative	0.003	0.0287	0.0251
Mycobacterium tuberculosis	Probable dehydrogenase	0.0099	0.2411	0.4811
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Echinococcus granulosus	thioredoxin glutathione reductase	0.0044	0.0724	0.1577
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0085	0.1997	0.421
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.087	0.0835
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.087	0.0835
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trypanosoma cruzi	DNA damage repair protein, putative	0.003	0.0287	0.0251
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.003	0.0287	0.2178
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0038	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.1192	0.2338
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0038	0.0079
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0125	0.32	1
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0055	0.1072	1
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0034	0.0409	0.0917
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0076	0.1698	0.358
Brugia malayi	6-phosphofructokinase	0.0125	0.32	0.6746
Toxoplasma gondii	6-phosphofructokinase	0.0034	0.0409	0.3242
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0076	0.1698	0.3697
Loa Loa (eye worm)	phosphofructokinase	0.0125	0.32	0.6746
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0034	0.0409	0.1175
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1841	0.1811
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0122	0.3108	0.6768
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0096	0.2312	0.5033
Schistosoma mansoni	hypothetical protein	0.0085	0.1997	0.421
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0409	0.3816
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.1604	0.3382
Brugia malayi	RNA binding protein	0.0073	0.1604	0.3382
Plasmodium vivax	6-phosphofructokinase, putative	0.0034	0.0409	0.3816
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.32	1
Leishmania major	trypanothione reductase	0.0043	0.0707	0.0672
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0076	0.1698	0.358
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0823	0.2484
Trypanosoma cruzi	DNA damage repair protein, putative	0.003	0.0287	0.0251
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.1395	0.1362
Schistosoma mansoni	ap endonuclease	0.0022	0.0038	0.0079
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0707	0.6594
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0122	0.3108	0.6553
Loa Loa (eye worm)	6-phosphofructokinase	0.0125	0.32	0.6746
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0085	0.1997	0.4347
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0076	0.1698	0.358
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0164	0.4404	0.4383
Echinococcus multilocularis	transcription factor Dp 1	0.0044	0.072	0.1518
Loa Loa (eye worm)	RNA binding protein	0.0073	0.1604	0.3382
Toxoplasma gondii	ThiF family protein	0.0036	0.0492	0.3965
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0346	1	1
Echinococcus granulosus	dna polymerase eta	0.0125	0.3208	0.6984
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0707	0.149
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0096	0.2312	0.4874
Mycobacterium ulcerans	DNA polymerase IV	0.0154	0.4089	0.821
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0409	0.5
Leishmania major	DNA polymerase kappa, putative	0.011	0.2753	0.2725
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0954	0.8002
Brugia malayi	glutathione reductase	0.0043	0.0707	0.149
Leishmania major	cathepsin L-like protease	0.0066	0.1395	0.1362
Mycobacterium ulcerans	6-phosphofructokinase	0.0125	0.32	0.6408
Trypanosoma cruzi	DNA polymerase eta, putative	0.0125	0.3208	0.3182
Trypanosoma brucei	hypothetical protein, conserved	0.003	0.0287	0.0251
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1841	0.1811
Brugia malayi	ImpB/MucB/SamB family protein	0.0096	0.2312	0.4874
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0707	0.1356
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0085	0.1997	0.4347
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0076	0.1698	0.358
Schistosoma mansoni	lipoxygenase	0.0085	0.1985	0.4186
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0036	0.0492	0.1071
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0125	0.32	0.3174
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0055	0.1069	0.2254
Schistosoma mansoni	6-phosphofructokinase	0.0125	0.32	0.6746
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.011	0.2753	0.2725
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1604	0.3382
Onchocerca volvulus		0.002	0	0.5
Schistosoma mansoni	ap endonuclease	0.0022	0.0038	0.0079
Echinococcus granulosus	histone acetyltransferase KAT2B	0.017	0.4593	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0125	0.32	0.3174
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0036	0.0492	0.0456
Brugia malayi	ImpB/MucB/SamB family protein	0.0125	0.3208	0.6763
Echinococcus multilocularis	6 phosphofructokinase	0.0125	0.32	0.6746
Trypanosoma brucei	DNA polymerase kappa, putative	0.0088	0.2064	0.2034
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.011	0.275	0.5497
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0034	0.0409	0.1175
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0031	0.0336	0.03
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0954	0.2263
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.087	0.0835
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0096	0.2312	0.4609
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0175	0.4743	1
Brugia malayi	Thioredoxin reductase	0.0043	0.0707	0.149
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0038	0.0082
Entamoeba histolytica	phosphofructokinase, putative	0.0125	0.32	1
Mycobacterium tuberculosis	Probable reductase	0.0099	0.2411	0.4811
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0099	0.2411	0.4811
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1604	0.3382
Echinococcus granulosus	tar DNA binding protein	0.0073	0.1604	0.3493
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1698	0.1667
Trypanosoma brucei	DNA polymerase IV, putative	0.0154	0.4089	0.4066
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0085	0.1997	0.421
Trypanosoma brucei	ubiquitin-activating enzyme E1, putative	0.0036	0.0492	0.0456
Toxoplasma gondii	phosphofructokinase PFKII	0.0034	0.0409	0.3242
Trypanosoma brucei	DNA polymerase IV, putative	0.0139	0.3648	0.3624
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1604	0.3382
Giardia lamblia	DINP protein human, muc B family	0.011	0.2753	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0096	0.2312	0.4874
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0346	1	1
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0055	0.1072	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1604	0.3382
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0125	0.32	0.6408
Toxoplasma gondii	hypothetical protein	0.0055	0.1072	0.9027
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0059	0.1192	0.1158
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0954	0.8905
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1072	0.226
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.1192	0.2512
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0055	0.1072	0.226
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.005	0.0916	0.1931
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.32	0.7806
Echinococcus granulosus	transcription factor Dp 1	0.0044	0.072	0.1568
Plasmodium vivax	SUMO-activating enzyme subunit 2, putative	0.0036	0.0492	0.4589
Trypanosoma brucei	DNA polymerase kappa, putative	0.011	0.2753	0.2725
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0175	0.4743	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.087	0.0835
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1395	0.1362
Mycobacterium ulcerans	DNA polymerase IV	0.0154	0.4089	0.821
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.122	0.1187
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0164	0.4404	0.4383
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.1192	0.2512
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0823	0.2893
Mycobacterium tuberculosis	Probable oxidoreductase	0.011	0.275	0.5497
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0059	0.1192	0.2594
Trypanosoma brucei	unspecified product	0.0066	0.1401	0.1368
Mycobacterium ulcerans	hypothetical protein	0.003	0.0287	0.0506
Trypanosoma brucei	DNA polymerase kappa, putative	0.0088	0.2064	0.2034
Schistosoma mansoni	hypothetical protein	0.0085	0.1997	0.421
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0096	0.2312	0.7192
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0034	0.0409	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0707	0.6594
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0154	0.4089	1
Brugia malayi	TAR-binding protein	0.0073	0.1604	0.3382
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0076	0.1698	0.5251
Loa Loa (eye worm)	apoptosis regulator protein	0.0085	0.1997	0.421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0823	0.7678
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0409	0.3816
Trypanosoma brucei	DNA damage repair protein, putative	0.003	0.0287	0.0251
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0346	1	1
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0707	0.584
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1698	0.1667
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0034	0.0409	0.1368
Echinococcus multilocularis	dna polymerase kappa	0.0154	0.4089	0.862
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.1604	0.3382
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0085	0.1997	0.421
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0954	0.8002
Trypanosoma brucei	hypothetical protein, conserved	0.003	0.0287	0.0251
Leishmania major	cathepsin L-like protease	0.0066	0.1395	0.1362
Trypanosoma brucei	DNA polymerase kappa, putative	0.008	0.1841	0.1811
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0055	0.1072	0.2334
Leishmania major	ubiquitin-activating enzyme-like protein	0.0036	0.0492	0.0456
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0038	0.0079
Schistosoma mansoni	DNA polymerase IV / kappa	0.003	0.0287	0.0605
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0954	0.2078
Echinococcus granulosus	dna polymerase kappa	0.0154	0.4089	0.8902
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0055	0.1072	0.226
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.1604	0.3382
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.011	0.275	0.5497
Echinococcus multilocularis	dna polymerase eta	0.0125	0.3208	0.6763
Leishmania major	DNA damage repair protein, putative	0.003	0.0287	0.0251
Schistosoma mansoni	hypothetical protein	0.0085	0.1997	0.421
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0059	0.1192	0.2338
Schistosoma mansoni	6-phosphofructokinase	0.0125	0.32	0.6746
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0036	0.0492	0.1037
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0707	0.0672
Giardia lamblia	DNA damage repair protein	0.003	0.0287	0.0919
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0076	0.1698	0.1667
Loa Loa (eye worm)	hypothetical protein	0.0125	0.3208	0.6763
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0059	0.1192	0.2512
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Onchocerca volvulus		0.002	0	0.5
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0707	0.6594
Echinococcus granulosus	6 phosphofructokinase	0.0125	0.32	0.6967
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.011	0.275	0.4297
Brugia malayi	acetyltransferase, GNAT family protein	0.0175	0.4743	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0954	0.2263
Trypanosoma brucei	chrX additional, unordered contigs	0.003	0.0287	0.0251
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0099	0.2411	0.4811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Plasmodium falciparum	glutathione reductase	0.0043	0.0707	0.6594
Leishmania major	DNA polymerase eta, putative	0.0059	0.1183	0.115
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.32	0.7806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Brugia malayi	6-phosphofructokinase	0.0125	0.32	0.6746
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0038	0.0351
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Loa Loa (eye worm)	acetyltransferase	0.0175	0.4743	1
Trypanosoma brucei	trypanothione reductase	0.0043	0.0707	0.0672
Trypanosoma cruzi	DNA polymerase eta, putative	0.0059	0.1183	0.115
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0096	0.2312	0.4874
Trichomonas vaginalis	phosphofructokinase, putative	0.0034	0.0409	0.0917
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1395	0.1362
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.1604	0.3382
Trypanosoma brucei	DNA polymerase kappa, putative	0.0154	0.4089	0.4066
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.0963	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0085	0.1997	0.421
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.0287	0.0251
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0059	0.1183	1
Toxoplasma gondii	hypothetical protein	0.0056	0.109	0.9182
Trypanosoma brucei	DNA polymerase eta, putative	0.0125	0.3208	0.3182
Brugia malayi	ThiF family protein	0.0055	0.1072	0.226
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.011	0.2753	0.5502
Leishmania major	cathepsin L-like protease	0.0066	0.1395	0.1362
Schistosoma mansoni	apoptosis regulator bax	0.0085	0.1997	0.421
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0099	0.2411	0.4811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.1395	0.1362
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0044	0.0728	0.6027
Leishmania major	DNA polymerase kappa, putative	0.003	0.0287	0.0251
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.1395	0.1362
Plasmodium falciparum	DNA repair protein REV1, putative	0.003	0.0287	0.2679
Schistosoma mansoni	DNA polymerase eta	0.0125	0.3208	0.6763
Trypanosoma brucei	unspecified product	0.0139	0.3648	0.3624
Loa Loa (eye worm)	ThiF family protein	0.0036	0.0492	0.1037
Brugia malayi	polk-prov protein	0.0088	0.2064	0.4352
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0034	0.0409	0.3816
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0096	0.2312	0.4874
Brugia malayi	ThiF family protein	0.0036	0.0492	0.1037
Mycobacterium ulcerans	hypothetical protein	0.0182	0.4972	1
Plasmodium vivax	DNA repair protein REV1, putative	0.003	0.0287	0.2679
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0099	0.2411	0.4811
Loa Loa (eye worm)	6-phosphofructokinase	0.0125	0.32	0.6746
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0125	0.32	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2064	0.4352
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0038	0.0351
Trypanosoma cruzi	hypothetical protein, conserved	0.003	0.0287	0.0251
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0076	0.1698	0.1667
Trichomonas vaginalis	DNA polymerase eta, putative	0.0154	0.4089	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0125	0.32	0.7806

Activities

Activity type	Activity value	Assay description	Source	Reference
AbsAC1 (functional)	= 21.95 uM	PubChem BioAssay. Small Molecule Inhibitors of FGF22-Mediated Excitatory Synaptogenesis & Epilepsy Measured in Biochemical System Using RT-PCR - 7012-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.2936 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3196458

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1877078