Detailed information for compound 1877575

Basic information

Technical information
  • TDR Targets ID: 1877575
  • Name: N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethyli dene]hydroxylamine
  • MW: 193.199 | Formula: C10H11NO3
  • H donors: 1 H acceptors: 1 LogP: 1.58 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1ccc2c(c1)OCCO2)\C
  • InChi: 1S/C10H11NO3/c1-7(11-12)8-2-3-9-10(6-8)14-5-4-13-9/h2-3,6,12H,4-5H2,1H3/b11-7+
  • InChiKey: OVZBNCGFDLVCLL-YRNVUSSQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (NE)-N-[1-(2,3-dihydro-1,4-benzodioxin-7-yl)ethylidene]hydroxylamine
  • MLS000712542
  • SMR000282309
  • ZINC03886464
  • STK208347
  • ZINC05027550

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0185 0.1784 0.1784
Plasmodium falciparum proteasome subunit beta type-5 0.0967 1 1
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0023 0.0082 0.0082
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0189 0.1824 0.1824
Entamoeba histolytica hypothetical protein 0.0031 0.0168 0.0168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0194 0.1876 0.1876
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0186 0.1787 0.1787
Giardia lamblia 26S protease regulatory subunit 6A 0.0016 0.001 0.001
Echinococcus granulosus enteropeptidase 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0967 1 1
Echinococcus granulosus gamma secretase subunit aph 1 0.0159 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0021 0.0021
Echinococcus multilocularis proteasome subunit beta type 6 0.0186 0.1787 0.1787
Toxoplasma gondii Proteasome/cyclosome repeat-containing protein 0.003 0.0149 0.0149
Leishmania major hypothetical protein, conserved 0.0038 0.0235 0.0235
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 6 0.0025 0.0103 0.0103
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0016 0.001 0.001
Trichomonas vaginalis proteasome regulatory subunits, putative 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0185 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0185 0.0185
Leishmania major proteasome regulatory non-ATP-ase subunit 8, putative,26S proteasome regulatory subunit, putative 0.0023 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0128 0.0128
Brugia malayi 26S proteasome non-ATPase regulatory subunit 7, putative 0.0023 0.0082 0.0082
Loa Loa (eye worm) proteasome subunit beta type 2 0.0206 0.1999 0.1999
Schistosoma mansoni hypothetical protein 0.0049 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni netrin receptor unc5 0.0028 0.0128 0.0128
Toxoplasma gondii 26s proteasome regulatory complex subunit, putative 0.0025 0.0103 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0418 0.0418
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0185 0.1784 0.1784
Toxoplasma gondii SAC3/GANP family protein 0.0022 0.007 0.007
Plasmodium vivax 26S proteasome regulatory subunit RPN8, putative 0.0023 0.0082 0.0082
Loa Loa (eye worm) proteasome Regulatory Particle 0.0025 0.0103 0.0103
Toxoplasma gondii hypothetical protein 0.002 0.0052 0.0052
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 4 0.0016 0.0009 0.0009
Trypanosoma cruzi Aph-1 protein, putative 0.0062 0.049 0.049
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0258 0.2549 0.2549
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0185 0.0185
Toxoplasma gondii peptidase, T1 family protein 0.0186 0.1797 0.1797
Toxoplasma gondii proteasome subunit beta type, putative 0.0967 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Plasmodium vivax proteasome subunit beta type-2, putative 0.0206 0.1999 0.1999
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0967 1 1
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 7, putative 0.0023 0.0074 0.0074
Brugia malayi small heat shock protein 0.0505 0.5144 0.5144
Loa Loa (eye worm) trypsin family protein 0.0029 0.0142 0.0142
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0185 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0185 0.0185
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0001 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0185 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0001 0.0001
Schistosoma mansoni 26S proteasome subunit S9 0.0028 0.0131 0.0131
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.0028 0.0131 0.0131
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0258 0.2549 0.2549
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0967 1 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0029 0.0142 0.0142
Giardia lamblia 26S proteasome regulatory subunit, putative 0.0017 0.002 0.002
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0129 0.0129
Brugia malayi 26S proteasome regulatory subunit rpn11 0.0023 0.0082 0.0082
Brugia malayi Hypothetical 35.8 kDa protein F37A4.5 in chromosome III 0.0023 0.0082 0.0082
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0185 0.0185
Brugia malayi Proteasome A-type and B-type family protein 0.0896 0.9259 0.9259
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0001 0.0001
Toxoplasma gondii proteasome regulatory subunit 0.0023 0.0082 0.0082
Trichomonas vaginalis 26S proteasome regulatory subunit S3, putative 0.0016 0.001 0.0009
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0185 0.178 0.178
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0194 0.1876 0.1876
Schistosoma mansoni hypothetical protein 0.0029 0.0142 0.0142
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0253 0.2493 0.2493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0185 0.0185
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0223 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0206 0.1999 0.1999
Echinococcus granulosus proteasome subunit beta type 6 0.0186 0.1787 0.1787
Loa Loa (eye worm) hypothetical protein 0.0028 0.0129 0.0129
Toxoplasma gondii proteasome 26S regulatory subunit 0.0016 0.0005 0.0005
Schistosoma mansoni adhesion regulating molecule 1 (110 kD cell membrane glycoprotein) 0.0073 0.0601 0.0601
Loa Loa (eye worm) 26S protease regulatory subunit 6A 0.0016 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0296 0.2951 0.2951
Leishmania major proteasome beta 2 subunit, putative 0.0258 0.2549 0.2549
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0253 0.2493 0.2493
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0022 0.007 0.007
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.016 0.1522 0.1522
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0185 0.0185
Brugia malayi Death domain containing protein 0.0028 0.0128 0.0128
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0185 0.0185
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0206 0.1999 0.1999
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0001 0.0001
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0029 0.0142 0.0142
Giardia lamblia Hypothetical protein 0.0028 0.0131 0.0131
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0001 0.0008
Toxoplasma gondii 26S proteasome regulatory subunit, S6a family AAA ATpase 0.0016 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0185 0.0185
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0194 0.1876 0.1876
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 7 0.0025 0.0103 0.0103
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0181 0.1737 0.1737
Leishmania major proteasome beta 3 subunit, putative 0.0181 0.1737 0.1737
Leishmania major proteasome beta-1 subunit, putative 0.0186 0.1787 0.1787
Toxoplasma gondii PCI domain-containing protein 0.0023 0.0081 0.0081
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0967 1 1
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0001 0.0001
Echinococcus multilocularis Mastin 0.0029 0.0142 0.0142
Brugia malayi 26S proteasome non-ATPase regulatory subunit Nin1/mts3 family protein 0.0022 0.007 0.007
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0181 0.1737 0.1737
Echinococcus granulosus carbonic anhydrase II 0.0131 0.1212 0.1212
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0181 0.1737 0.1737
Plasmodium falciparum proteasome subunit beta type-4 0.0179 0.1723 0.1723
Brugia malayi ecdysone receptor 0.0016 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0185 0.0185
Brugia malayi Proteasome subunit alpha type 1 0.0172 0.1648 0.1648
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0185 0.0185
Echinococcus multilocularis Ankyrin 0.0028 0.0129 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Plasmodium vivax proteasome subunit beta type-3, putative 0.0181 0.1737 0.1737
Trypanosoma cruzi Aph-1 protein, putative 0.0062 0.049 0.049
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0016 0.0009 0.0009
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0001 0.0001
Leishmania major proteasome beta 2 subunit, putative 0.0206 0.1999 0.1999
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0001 0.0001
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0128 0.0128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0185 0.0185
Plasmodium vivax 26S proteasome regulatory subunit RPN12, putative 0.0022 0.007 0.007
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0185 0.178 0.178
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0223 0.2182 0.2182
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 2 0.0033 0.0187 0.0187
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0179 0.1723 0.1723
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Plasmodium falciparum 26S proteasome regulatory subunit RPN8, putative 0.0023 0.0082 0.0082
Trichomonas vaginalis 26S protease regulatory subunit, putative 0.0016 0.001 0.001
Giardia lamblia 20S proteasome alpha subunit 4 0.0223 0.2182 0.2182
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0001 0.0001
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0206 0.1999 0.1999
Leishmania major proteasome beta 5 subunit, putative 0.0967 1 1
Brugia malayi Adhesion regulating molecule conserved region family protein 0.0073 0.0601 0.0601
Trypanosoma brucei proteasome regulatory ATPase subunit 5 0.0016 0.001 0.001
Echinococcus granulosus proteasome subunit beta type 7 0.0896 0.9259 0.9259
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0185 0.178 0.178
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Brugia malayi steroid hormone receptor 0.0033 0.0185 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0021 0.0021
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 8 0.0022 0.007 0.007
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0253 0.2493 0.2493
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0223 0.2182 0.2182
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0194 0.1876 0.1876
Schistosoma mansoni nuclear receptor 0.0016 0.0001 0.0001
Echinococcus granulosus 26S proteasome regulatory subunit N1 0.0023 0.0081 0.0081
Plasmodium vivax 26S proteasome regulatory subunit RPN11, putative 0.0023 0.0082 0.0082
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0025 0.0103 0.0103
Brugia malayi nuclear receptor RXR 0.0018 0.0021 0.0021
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0194 0.1876 0.1876
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 5, putative 0.0025 0.0104 0.0104
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 0.0022 0.007 0.007
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0033 0.0187 0.0187
Plasmodium vivax 26S proteasome regulatory subunit RPN2, putative 0.003 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0023 0.0081 0.0081
Echinococcus granulosus carbonic anhydrase 0.0049 0.0348 0.0348
Echinococcus granulosus proteasome subunit alpha type 6 0.0195 0.1883 0.1883
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.0028 0.0131 0.0131
Mycobacterium ulcerans proteasome PrcB 0.0967 1 1
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 7, putative 0.0025 0.0103 0.0103
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0181 0.1737 0.1737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0185 0.0185
Brugia malayi hypothetical protein 0.0018 0.0021 0.0021
Trypanosoma brucei proteasome beta 7 subunit 0.0179 0.1723 0.1723
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0185 0.0185
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0418 0.0418
Brugia malayi Trypsin-like protease protein 5 0.0029 0.0142 0.0142
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit, putative 0.0023 0.0082 0.0082
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0195 0.1883 0.1883
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 6, putative 0.0028 0.0131 0.0131
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0001 0.0001
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0967 1 1
Giardia lamblia Proteasome subunit beta type 3 0.0181 0.1737 0.1737
Loa Loa (eye worm) RPT-2 protein 0.0015 0.0000012771 0.0000012771
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.003 0.0154 0.0154
Echinococcus granulosus proteasome subunit beta t family 0.0181 0.1737 0.1737
Schistosoma mansoni hypothetical protein 0.009 0.0788 0.0788
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0185 0.0185
Echinococcus multilocularis nuclear factor of activated T cells 5 0.027 0.2679 0.2679
Brugia malayi conserved hypotetical protein 0.0016 0.0001 0.0001
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0223 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.0505 0.5144 0.5144
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0185 0.0185
Brugia malayi nuclear receptor NHR-88 0.0016 0.0001 0.0001
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0186 0.1787 0.1787
Brugia malayi Chain A, Structure Of A Brca2-Dss1 Complex. 0.0165 0.1574 0.1574
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0131 0.1212 0.1212
Echinococcus granulosus glycoprotein Antigen 5 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0181 0.1737 0.1737
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0016 0.0009 0.0009
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0223 0.2182 0.2182
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0223 0.2182 0.2182
Onchocerca volvulus 0.0029 0.0142 0.079
Toxoplasma gondii 26s proteasome subunit p55, putative 0.0025 0.0104 0.0104
Entamoeba histolytica hypothetical protein 0.003 0.0149 0.0149
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0023 0.0082 0.0082
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0131 0.1212 0.1212
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0103 0.0103
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0185 0.0185
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0021 0.0021
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0185 0.1784 0.1784
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0258 0.2549 0.2549
Plasmodium falciparum 26S proteasome regulatory subunit RPN3, putative 0.003 0.0154 0.0154
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0185 0.178 0.178
Schistosoma mansoni carbonic anhydrase 0.0049 0.0348 0.0348
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0185 0.1784 0.1784
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0195 0.1883 0.1883
Brugia malayi Trypsin family protein 0.0029 0.0142 0.0142
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0001 0.0001
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0001 0.0001
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0185 0.178 0.178
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0418 0.0418
Plasmodium vivax 26S proteasome regulatory subunit RPN7, putative 0.0025 0.0103 0.0103
Toxoplasma gondii proteasome subunit alpha type, putative 0.0185 0.1784 0.1784
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Brugia malayi hypothetical protein 0.0029 0.0142 0.0142
Brugia malayi nuclear hormone receptor 0.0016 0.0001 0.0001
Onchocerca volvulus 0.0033 0.0185 0.1032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0185 0.0185
Brugia malayi tailless protein 0.0016 0.0001 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0001 0.0001
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0128 0.0128
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0258 0.2549 0.2549
Brugia malayi Protein kinase domain containing protein 0.0028 0.0128 0.0128
Brugia malayi Proteasome A-type and B-type family protein 0.0179 0.1723 0.1723
Brugia malayi Trypsin family protein 0.0029 0.0142 0.0142
Brugia malayi Uncoordinated protein 44 0.0028 0.0128 0.0128
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0049 0.0348 0.0348
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.016 0.1522 0.1522
Trichomonas vaginalis regulatory particle non-ATPase, putative 0.0023 0.0081 0.0081
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.007 0.007
Brugia malayi hypothetical protein 0.0018 0.0021 0.0021
Schistosoma mansoni zinc finger protein 0.0016 0.0001 0.0001
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 12 0.0025 0.0104 0.0104
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma brucei 19S proteasome non-atpase subunit 8 0.0023 0.0082 0.0082
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0194 0.1876 0.1876
Echinococcus granulosus DSS1 SEM1 domain containing protein 0.0067 0.0545 0.0545
Loa Loa (eye worm) 26S proteasome regulatory complex subunit p97 0.0033 0.0187 0.0187
Echinococcus multilocularis carbonic anhydrase 0.0049 0.0348 0.0348
Echinococcus granulosus proteasome subunit alpha type 2 0.0189 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Trichomonas vaginalis 26S proteasome subunit S9, putative 0.0028 0.0131 0.0131
Brugia malayi 26S protease regulatory subunit 6A 0.0016 0.001 0.001
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0025 0.0103 0.0103
Onchocerca volvulus 0.0029 0.0142 0.079
Entamoeba histolytica hypothetical protein 0.0031 0.0168 0.0168
Trypanosoma brucei carbonic anhydrase-like protein 0.0131 0.1212 0.1212
Plasmodium falciparum 26S proteasome regulatory subunit RPN7, putative 0.0025 0.0103 0.0103
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 7 0.0023 0.0082 0.0082
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0967 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0031 0.0168 0.0168
Echinococcus granulosus transmembrane protease serine 3 0.0029 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0073 0.0601 0.0601
Loa Loa (eye worm) RPN-3 protein 0.003 0.0154 0.0154
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0185 0.178 0.178
Onchocerca volvulus 0.0029 0.0142 0.079
Giardia lamblia Proteasome subunit beta type 1 0.0253 0.2493 0.2493
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0179 0.1723 0.1723
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0418 0.0418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0031 0.0168 0.0168
Onchocerca volvulus Notchless protein homolog 0.0186 0.1797 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0185 0.0185
Brugia malayi Proteasome/cyclosome repeat family protein 0.0025 0.0097 0.0097
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.016 0.1522 0.1522
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 8 0.0022 0.007 0.007
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0001 0.0001
Giardia lamblia 20S proteasome alpha subunit 3 0.0185 0.1784 0.1784
Brugia malayi proteasome subunit alpha type 2 0.0189 0.1824 0.1824
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0049 0.0348 0.0348
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0186 0.1797 0.1797
Trypanosoma cruzi proteasome regulatory non-ATPase subunit, putative 0.0022 0.007 0.007
Plasmodium vivax 26S proteasome regulatory subunit RPN1, putative 0.0033 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0128 0.0128
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0181 0.1737 0.1737
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0185 0.0185
Brugia malayi PCI domain containing protein 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis 26s protease regulatory subunit 6a 0.0016 0.001 0.001
Echinococcus granulosus subfamily T1A non peptidase ue 0.0194 0.1876 0.1876
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0223 0.2182 0.2182
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0185 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0185 0.0185
Onchocerca volvulus 0.0016 0.0001 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0185 0.0185
Trypanosoma brucei ATP-dependent protease subunit HslV 0.016 0.1522 0.1522
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0186 0.1787 0.1787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0418 0.0418
Echinococcus granulosus 26S proteasome regulatory subunit N11 0.0023 0.0082 0.0082
Echinococcus multilocularis geminin 0.0296 0.2951 0.2951
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0185 0.0185
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0189 0.1824 0.1824
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0189 0.1824 0.1824
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0185 0.0185
Plasmodium falciparum 26S proteasome regulatory subunit RPN9, putative 0.0023 0.0081 0.0081
Echinococcus granulosus 26s proteasome regulatory particle subunit 0.0033 0.0187 0.0187
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0185 0.0185
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0001 0.0001
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0186 0.1787 0.1787
Giardia lamblia 20S proteasome alpha subunit 6 0.0185 0.178 0.178
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.007 0.007
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0179 0.1723 0.1723
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0185 0.0185
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0185 0.178 0.178
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0022 0.007 0.007
Trypanosoma brucei proteasome regulatory non-ATPase subunit 6 0.0028 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0165 0.1574 0.1574
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Leishmania major proteasome alpha 1 subunit, putative 0.0185 0.178 0.178
Brugia malayi PCI domain containing protein 0.0023 0.0081 0.0081
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 4 0.0016 0.0009 0.0009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0206 0.1999 0.1999
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0185 0.178 0.178
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0187 0.0187
Trichomonas vaginalis 26S proteasome regulatory subunit, putative 0.0025 0.0097 0.0097
Loa Loa (eye worm) DR-78 0.0016 0.0001 0.0001
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0253 0.2493 0.2493
Brugia malayi Trypsin family protein 0.0029 0.0142 0.0142
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0181 0.1744 0.1744
Leishmania major proteasome alpha 1 subunit, putative 0.0195 0.1883 0.1883
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0185 0.1784 0.1784
Leishmania major proteasome regulatory non-ATPase subunit 6, putative 0.0028 0.0131 0.0131
Echinococcus granulosus Proteasome subunit alpha beta 0.0186 0.1797 0.1797
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0206 0.1999 0.1999
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0258 0.2549 0.2549
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0177 0.1692 0.1692
Echinococcus granulosus Proteasome subunit alpha type 7 0.0223 0.2182 0.2182
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Giardia lamblia 26S proteasome non-ATPase regulatory subunit 6 0.0025 0.0103 0.0103
Entamoeba histolytica proteasome regulatory subunit, putative 0.003 0.0154 0.0154
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.016 0.1522 0.1522
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0049 0.0348 0.0348
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Plasmodium falciparum 26S protease regulatory subunit 6A, putative 0.0016 0.001 0.001
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0186 0.1797 0.1797
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0016 0.001 0.001
Brugia malayi Probable 26S proteasome non-ATPase regulatory subunit 3 0.003 0.0154 0.0154
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0185 0.0185
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0131 0.1212 0.1212
Brugia malayi Proteasome regulatory particle, non-atpase-like protein 6 0.0028 0.0131 0.0131
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0189 0.1824 0.1824
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0128 0.0128
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0049 0.0348 0.0348
Brugia malayi proteasome subunit beta type 1 0.0253 0.2493 0.2493
Trypanosoma brucei proteasome beta 6 subunit 0.0253 0.2493 0.2493
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0185 0.0185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0185 0.0185
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0206 0.1999 0.1999
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0253 0.2493 0.2493
Brugia malayi proteasome subunit alpha type 4 0.0173 0.1652 0.1652
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0185 0.0185
Onchocerca volvulus Proteasomal ubiquitin receptor ADRM1 homolog 0.0046 0.0322 0.1793
Plasmodium vivax proteasome subunit beta type-5, putative 0.0967 1 1
Schistosoma mansoni nuclear receptor 0.0016 0.0001 0.0001
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0258 0.2549 0.2549
Toxoplasma gondii heat shock protein hslv, putative 0.016 0.1522 0.1522
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0194 0.1876 0.1876
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0187 0.0187
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0195 0.1883 0.1883
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0159 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.0015 0.0000012771 0.0000012771
Loa Loa (eye worm) 26S proteasome non-ATPase regulatory subunit 7 0.0023 0.0082 0.0082
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0223 0.2182 0.2182
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 0.003 0.0149 0.0149
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 5 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi proteasome subunit beta type 2 0.0206 0.1999 0.1999
Trichomonas vaginalis 26S proteasome subunit, putative 0.0023 0.0081 0.0081
Giardia lamblia 20S proteasome alpha subunit 1 0.0195 0.1883 0.1883
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 2 0.003 0.0149 0.0149
Echinococcus multilocularis proteasome (prosome, macropain) 0.0967 1 1
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0206 0.1999 0.1999
Leishmania major carbonic anhydrase-like protein 0.0131 0.1212 0.1212
Schistosoma mansoni multiubiquitin binding protein S5a 0.0016 0.0009 0.0009
Brugia malayi nuclear hormone receptor 0.0033 0.0185 0.0185
Giardia lamblia 20S proteasome alpha subunit 7 0.0186 0.1797 0.1797
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0194 0.1876 0.1876
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.016 0.1522 0.1522
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0185 0.0185
Loa Loa (eye worm) PCI domain-containing protein 0.0025 0.0104 0.0104
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0181 0.1737 0.1737
Plasmodium vivax proteasome subunit beta type-6, putative 0.0186 0.1787 0.1787
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 0.003 0.0149 0.0149
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Plasmodium vivax proteasome subunit beta type-7, putative 0.0258 0.2549 0.2549
Plasmodium falciparum 26S proteasome regulatory subunit RPN13, putative 0.0038 0.0235 0.0235
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0206 0.1999 0.1999
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0223 0.2182 0.2182
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0173 0.1654 0.1654
Echinococcus granulosus carbonic anhydrase 0.0049 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.016 0.1522 0.1522
Loa Loa (eye worm) proteasome/cyclosome repeat family protein 0.0025 0.0097 0.0097
Trypanosoma brucei 26S proteasome regulatory non-ATPase subunit 0.0033 0.0187 0.0187
Entamoeba histolytica hypothetical protein 0.0031 0.0168 0.0168
Leishmania major proteasome regulatory ATPase subunit 5, putative 0.0016 0.001 0.001
Schistosoma mansoni carbonic anhydrase-related 0.0049 0.0348 0.0348
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Trypanosoma cruzi 19S proteasome non-atpase subunit 8 0.0023 0.0082 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0185 0.1032
Echinococcus granulosus nuclear factor of activated T cells 5 0.027 0.2679 0.2679
Onchocerca volvulus 0.0029 0.0142 0.079
Loa Loa (eye worm) hypothetical protein 0.0049 0.0348 0.0348
Loa Loa (eye worm) PAS-3 protein 0.0173 0.1652 0.1652
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0001 0.0001
Brugia malayi proteasome subunit beta type 3 0.0181 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0128 0.0711
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 6 0.0025 0.0103 0.0103
Entamoeba histolytica proteasome regulatory subunit, putative 0.0023 0.0081 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0185 0.0185
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0179 0.1723 0.1723
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0185 0.1784 0.1784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0418 0.0418
Entamoeba histolytica proteasome regulatory subunit, putative 0.0025 0.0104 0.0104
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0001 0.0001
Toxoplasma gondii proteasome subunit alpha1, putative 0.0195 0.1883 0.1883
Entamoeba histolytica 19S cap proteasome S2 subunit 0.0016 0.0005 0.0005
Entamoeba histolytica proteasome regulatory subunit, putative 0.0028 0.0131 0.0131
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0181 0.1737 0.1737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0418 0.0418
Brugia malayi Trypsin family protein 0.0029 0.0142 0.0142
Brugia malayi hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0029 0.0142 0.0142
Schistosoma mansoni hypothetical protein 0.0296 0.2951 0.2951
Plasmodium falciparum 26S proteasome regulatory subunit RPN1, putative 0.0033 0.0187 0.0187
Entamoeba histolytica proteasome regulatory subunit, putative 0.0016 0.0009 0.0009
Schistosoma mansoni gamma-secretase subunit aph-1 0.0159 0.1511 0.1511
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0131 0.1212 0.1212
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0194 0.1876 0.1876
Schistosoma mansoni 26S proteasome regulatory subunit rpn2 0.003 0.0149 0.0149
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0185 0.0185
Trypanosoma cruzi 20S proteasome subunit 0.0206 0.1999 0.1999
Loa Loa (eye worm) proteasome subunit beta type 1 0.0253 0.2493 0.2493
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0223 0.2182 0.2182
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0253 0.2493 0.2493
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0185 0.1032
Brugia malayi Proteasome A-type and B-type family protein 0.0186 0.1787 0.1787
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0177 0.1692 0.1692
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0128 0.0128
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0033 0.0187 0.0187
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Entamoeba histolytica hypothetical protein 0.0031 0.0168 0.0168
Leishmania major proteasome regulatory non-ATP-ase subunit 5, putative,19S proteasome regulatory subunit 0.0025 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Brugia malayi nuclear receptor RXR 0.0016 0.0001 0.0001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0001 0.0001
Echinococcus granulosus geminin 0.0296 0.2951 0.2951
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0179 0.1723 0.1723
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0185 0.1784 0.1784
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0185 0.0185
Leishmania major proteasome beta 7 subunit, putative 0.0179 0.1723 0.1723
Brugia malayi Proteasome subunit alpha type 7-1 0.0223 0.2182 0.2182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0185 0.0185
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0185 0.178 0.178
Echinococcus granulosus 26s protease regulatory subunit 6a 0.0016 0.001 0.001
Plasmodium falciparum 26S proteasome regulatory subunit RPN11, putative 0.0023 0.0082 0.0082
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0185 0.1784 0.1784
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0186 0.1797 0.1797
Plasmodium falciparum 26S proteasome regulatory subunit RPN12, putative 0.0022 0.007 0.007
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0258 0.2549 0.2549
Echinococcus multilocularis DSS1 (SEM1) domain containing protein 0.0067 0.0545 0.0545
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0185 0.0185
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0967 1 1
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0179 0.1723 0.1723
Toxoplasma gondii PCI domain-containing protein 0.0028 0.0131 0.0131
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0967 1 1
Echinococcus multilocularis transmembrane protease serine 3 0.0029 0.0142 0.0142
Trypanosoma brucei Aph-1 protein, putative 0.0062 0.049 0.049
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0186 0.1787 0.1787
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0206 0.1999 0.1999
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0001 0.0001
Brugia malayi Proteasome/cyclosome repeat family protein 0.0025 0.0097 0.0097
Leishmania major proteasome regulatory non-ATP-ase subunit, putative 0.0023 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0165 0.1574 0.1574
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0189 0.1824 0.1824
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0185 0.0185
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0189 0.1824 0.1824
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0185 0.1032
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0001 0.0001
Toxoplasma gondii Mov34/MPN/PAD-1 family protein 0.0023 0.0082 0.0082
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0179 0.1723 0.1723
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0185
Toxoplasma gondii proteasome beta subunit 0.0181 0.1737 0.1737
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0418 0.0418
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0185 0.178 0.178
Giardia lamblia 20S proteasome alpha subunit 5 0.0194 0.1876 0.1876
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0185 0.0185
Entamoeba histolytica proteasome regulatory subunit, putative 0.0022 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0028 0.0128 0.0128
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0185 0.1784 0.1784
Leishmania major proteasome alpha 3 subunit, putative 0.0185 0.1784 0.1784
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0021 0.0021
Brugia malayi 20S proteasome alpha5 subunit 0.0194 0.1876 0.1876
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0194 0.1876 0.1876
Toxoplasma gondii proteasome subunit 0.0186 0.1787 0.1787
Brugia malayi hypothetical protein 0.0031 0.0168 0.0168
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0194 0.1876 0.1876
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0194 0.1876 0.1876
Loa Loa (eye worm) hypothetical protein 0.0049 0.0348 0.0348
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0001 0.0001
Plasmodium falciparum carbonic anhydrase 0.0049 0.0348 0.0348
Echinococcus multilocularis 26s proteasome regulatory particle subunit 0.0033 0.0187 0.0187
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0195 0.1883 0.1883
Brugia malayi ecdysteroid receptor 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Plasmodium vivax proteasome subunit beta type-4, putative 0.0179 0.1723 0.1723
Trichomonas vaginalis cop9 signalosome complex subunit, putative 0.0025 0.0103 0.0103
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0186 0.1787 0.1787
Loa Loa (eye worm) 26S proteasome regulatory subunit rpn11 0.0023 0.0082 0.0082
Echinococcus multilocularis proteasome subunit beta type 7 0.0896 0.9259 0.9259
Echinococcus multilocularis carbonic anhydrase 0.0049 0.0348 0.0348
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0185 0.0185
Schistosoma mansoni 26s proteasome regulatory particle subunit 0.0033 0.0187 0.0187
Leishmania major proteasome regulatory non-ATP-ase subunit 3, putative 0.003 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0185 0.0185
Toxoplasma gondii PCI domain-containing protein 0.003 0.0154 0.0154
Brugia malayi proteasome subunit alpha type 3 0.0186 0.1797 0.1797
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0179 0.1723 0.1723
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0967 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0185 0.0185
Schistosoma mansoni 26s proteasome non-ATPase regulatory subunit 4 0.0016 0.0009 0.0009
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0253 0.2493 0.2493
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0194 0.1876 0.1876
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0967 1 1
Leishmania major proteasome alpha 7 subunit, putative 0.0186 0.1797 0.1797
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0016 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0185 0.0185
Loa Loa (eye worm) PCI domain-containing protein 0.0023 0.0081 0.0081
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0223 0.2182 0.2182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0128 0.0128
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0186 0.1797 0.1797
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0253 0.2493 0.2493
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 9 0.0023 0.0081 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0185 0.0185
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0186 0.1787 0.1787
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0185 0.0185
Trypanosoma cruzi proteasome regulatory non-ATP-ase subunit 9, putative 0.0023 0.0081 0.0081
Leishmania major proteasome regulatory non-ATPase subunit, putative 0.0033 0.0187 0.0187
Toxoplasma gondii hypothetical protein 0.0049 0.0348 0.0348
Entamoeba histolytica 26S proteasome non-ATPase regulatory subunit 14, putative 0.0023 0.0082 0.0082
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0186 0.1797 0.1797
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0185 0.178 0.178
Trichomonas vaginalis 26S proteasome regulatory subunit rpn1, putative 0.0017 0.002 0.002
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0181 0.1737 0.1737
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0186 0.1797 0.1797
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 7 0.0023 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Echinococcus multilocularis proteasome subunit alpha type 6 0.0195 0.1883 0.1883
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0253 0.2493 0.2493
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0131 0.1212 0.1212
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0029 0.0142 0.0142
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0131 0.1212 0.1212
Echinococcus multilocularis carbonic anhydrase II 0.0131 0.1212 0.1212
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0186 0.1797 0.1797
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.016 0.1522 0.5
Echinococcus multilocularis carbonic anhydrase 0.0049 0.0348 0.0348
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 3 0.003 0.0154 0.0154
Brugia malayi nuclear receptor NHR-88 0.0033 0.0185 0.0185
Plasmodium vivax 26S proteasome regulatory subunit RPN6, putative 0.0028 0.0131 0.0131
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0185 0.1784 0.1784
Echinococcus granulosus proteasome prosome macropain 0.0967 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.0545 0.0545
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0186 0.1797 0.1797
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0194 0.1876 0.1876
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0186 0.1787 0.1787
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0189 0.1824 0.1824
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0206 0.1999 0.1999
Echinococcus multilocularis glycoprotein Antigen 5 0.0029 0.0142 0.0142
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 6 0.0025 0.0103 0.0103
Brugia malayi 26S proteasome regulatory complex subunit p97 0.0033 0.0187 0.0187
Plasmodium falciparum 26S proteasome regulatory subunit p55, putative 0.0025 0.0104 0.0104
Schistosoma mansoni carbonic anhydrase-related 0.0049 0.0348 0.0348
Onchocerca volvulus 0.0029 0.0142 0.079
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0185 0.0185
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0001 0.0001
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0049 0.0348 0.0348
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0223 0.2182 0.2182
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0206 0.1999 0.1999
Echinococcus granulosus carbonic anhydrase 0.0049 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0001
Brugia malayi gamma-secretase subunit aph-1 0.0159 0.1511 0.1511
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0016 0.0009 0.0009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0258 0.2549 0.2549
Plasmodium vivax 26S protease regulatory subunit 6a, putative 0.0016 0.001 0.001
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0195 0.1883 0.1883
Schistosoma mansoni transcription factor LCR-F1 0.0031 0.0168 0.0168
Plasmodium vivax proteasome subunit beta type-1, putative 0.0253 0.2493 0.2493
Echinococcus multilocularis 26S proteasome regulatory subunit N11 0.0023 0.0082 0.0082
Echinococcus multilocularis proteasome subunit alpha type 2 0.0189 0.1824 0.1824
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0418 0.0418
Echinococcus granulosus Ankyrin 0.0028 0.0129 0.0129
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0185 0.0185
Schistosoma mansoni 26S proteasome regulatory subunit S3 0.003 0.0154 0.0154
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0128 0.0128
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 12 0.0025 0.0104 0.0104
Echinococcus multilocularis 26S proteasome regulatory subunit N1 0.0023 0.0081 0.0081
Plasmodium vivax 26S proteasome regulatory subunit RPN9, putative 0.0023 0.0081 0.0081
Brugia malayi Ubiquitin interaction motif family protein 0.0016 0.0009 0.0009
Loa Loa (eye worm) proteasome regulatory particle 0.0028 0.0131 0.0131
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0179 0.1723 0.1723
Leishmania major proteasome alpha 7 subunit, putative 0.0223 0.2182 0.2182
Echinococcus granulosus 26S proteasome regulatory subunit S3 0.003 0.0154 0.0154
Trypanosoma cruzi proteasome regulatory ATPase subunit 5, putative 0.0016 0.001 0.001
Schistosoma mansoni 26S protease regulatory subunit 6a 0.0016 0.001 0.001
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0896 0.9259 0.9259
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0223 0.2182 0.2182
Brugia malayi proteasome subunit alpha type 1 0.0185 0.178 0.178
Plasmodium falciparum 26S proteasome regulatory subunit RPN2, putative 0.003 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0021
Trypanosoma cruzi 26S proteasome regulatory non-ATPase subunit, putative 0.0016 0.0005 0.0005
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0189 0.1824 0.1824
Toxoplasma gondii adhesion regulating molecule region protein, putative 0.0073 0.0601 0.0601
Echinococcus multilocularis gamma secretase subunit aph 1 0.0159 0.1511 0.1511
Onchocerca volvulus 0.0029 0.0142 0.079
Onchocerca volvulus 0.0016 0.0001 0.0008
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0001 0.0001
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0195 0.1883 0.1883
Loa Loa (eye worm) carbonic anhydrase 3 0.0131 0.1212 0.1212
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0253 0.2493 0.2493
Echinococcus multilocularis enteropeptidase 0.0029 0.0142 0.0142
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0186 0.1787 0.1787
Schistosoma mansoni cercarial elastase (S01 family) 0.0029 0.0142 0.0142
Echinococcus multilocularis adhesion regulating molecule 1 0.0073 0.0601 0.0601
Schistosoma mansoni proteasome regulatory subunit-related 0.0025 0.0104 0.0104
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0186 0.1797 0.1797
Giardia lamblia 20S proteasome alpha subunit 2 0.0189 0.1824 0.1824
Schistosoma mansoni hypothetical protein 0.0031 0.0168 0.0168
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.007
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0049 0.0348 0.0348
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0195 0.1883 0.1883
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0001 0.0008
Mycobacterium ulcerans proteasome PrcA 0.016 0.1522 0.14
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0049 0.0348 0.0348
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.016 0.1522 0.1522
Echinococcus granulosus Mastin 0.0029 0.0142 0.0142
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0186 0.1797 0.1797
Trypanosoma cruzi proteasome regulatory non-ATPase subunit 3, putative 0.003 0.0154 0.0154
Trypanosoma brucei proteasome alpha 7 subunit 0.0186 0.1797 0.1797
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0185 0.0185
Echinococcus granulosus death domain containing protein 0.0028 0.0128 0.0128
Brugia malayi nuclear receptor NHR-67 0.0016 0.0001 0.0001
Echinococcus granulosus adhesion regulating molecule 1 0.0073 0.0601 0.0601
Trypanosoma brucei proteasome regulatory non-ATP-ase subunit 0.0022 0.007 0.007
Schistosoma mansoni carbonic anhydrase-related 0.0049 0.0348 0.0348
Giardia lamblia Proteasome subunit beta type 2 0.0206 0.1999 0.1999
Schistosoma mansoni 26S proteasome non-ATPase regulatory subunit 7 0.0023 0.0082 0.0082
Loa Loa (eye worm) proteasome subunit beta type 3 0.0181 0.1737 0.1737
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0001 0.0001
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0185 0.1784 0.1784
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0195 0.1883 0.1883
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0185 0.0185
Leishmania major proteasome alpha 2 subunit, putative 0.0189 0.1824 0.1824
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0195 0.1883 0.1883
Brugia malayi proteasome subunit alpha type 6 0.0195 0.1883 0.1883
Toxoplasma gondii proteasome subunit alpha type, putative 0.0063 0.0497 0.0497
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0029 0.0142 0.0142
Plasmodium falciparum 26S proteasome regulatory subunit RPN6 0.0028 0.0131 0.0131
Trichomonas vaginalis Clan MP, family M67, Poh1-like metallopeptidase 0.0023 0.0082 0.0082
Schistosoma mansoni coup transcription factor 0.0033 0.0185 0.0185
Echinococcus multilocularis 26S proteasome regulatory subunit S3 0.003 0.0154 0.0154
Entamoeba histolytica 26S protease regulatory subunit, putative 0.0016 0.001 0.001
Plasmodium vivax 26S proteasome regulatory subunit p55, putative 0.0025 0.0104 0.0104
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0179 0.1723 0.1723
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0131 0.1212 0.1212

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1169 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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