Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2627 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0241 | 0.0311 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2627 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.111 | 0.0895 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0543 | 0.0309 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2036 | 0.1843 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2627 | 0.2445 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.2521 | 0.9595 |
Onchocerca volvulus | 0.0035 | 0.111 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0543 | 0.2066 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2627 | 0.2449 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0543 | 0.1537 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.2236 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1182 | 0.4498 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1856 | 0.7064 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1856 | 0.6868 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0241 | 0.0311 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2036 | 0.1839 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0543 | 0.1537 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1856 | 0.1659 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1856 | 0.6868 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1345 | 0.5119 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2627 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1856 | 0.6868 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0543 | 0.1537 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1856 | 0.7064 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2627 | 0.2445 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.111 | 0.4225 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.111 | 0.0891 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1345 | 0.1136 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1856 | 0.6868 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0137 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0032 | 0.0122 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2036 | 0.1843 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2627 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0137 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2627 | 0.2445 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2627 | 0.2449 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0543 | 0.1537 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0543 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2036 | 0.1839 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.1182 | 0.4131 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.1182 | 0.4131 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2627 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0543 | 0.2066 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0164 | 0.0625 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0137 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2627 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1856 | 0.7064 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0543 | 0.0314 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0543 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0543 | 0.0309 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0543 | 0.1537 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0543 | 0.1537 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2627 | 0.2449 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1856 | 0.1655 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0137 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1345 | 0.1131 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2627 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0543 | 0.0314 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1182 | 0.4498 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0137 | 1 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7943 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.