Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0882 | 0.1737 |
Schistosoma mansoni | gliotactin | 0.0059 | 0.1246 | 0.2454 |
Echinococcus multilocularis | neuroligin | 0.0059 | 0.1246 | 0.1734 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0059 | 0.1246 | 0.2454 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.6896 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0177 | 0.5078 | 0.7364 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0489 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0177 | 0.5078 | 0.734 |
Echinococcus granulosus | carboxylesterase 5A | 0.0177 | 0.5078 | 0.734 |
Echinococcus multilocularis | acetylcholinesterase | 0.0177 | 0.5078 | 0.734 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0802 | 0.0985 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.1246 | 0.1641 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0059 | 0.1246 | 0.2454 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0882 | 0.1102 |
Brugia malayi | hypothetical protein | 0.0234 | 0.6896 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.1246 | 0.1641 |
Loa Loa (eye worm) | carboxylesterase | 0.0059 | 0.1246 | 0.1807 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0059 | 0.1246 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.1246 | 0.1641 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.6896 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0802 | 0.1084 |
Brugia malayi | Carboxylesterase family protein | 0.0059 | 0.1246 | 0.1641 |
Onchocerca volvulus | 0.0059 | 0.1246 | 1 | |
Echinococcus granulosus | acetylcholinesterase | 0.0177 | 0.5078 | 0.734 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Onchocerca volvulus | 0.0059 | 0.1246 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0059 | 0.1246 | 0.1734 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0059 | 0.1246 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0564 | 0.0633 |
Schistosoma mansoni | acetylcholinesterase | 0.0059 | 0.1246 | 0.2454 |
Onchocerca volvulus | 0.0059 | 0.1246 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0059 | 0.1246 | 0.1807 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0177 | 0.5078 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0802 | 0.1084 |
Onchocerca volvulus | 0.0059 | 0.1246 | 1 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0802 | 0.158 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.1246 | 0.2454 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0802 | 0.1084 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.1737 | 0.2368 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0061 | 0.012 |
Brugia malayi | hypothetical protein | 0.0059 | 0.1246 | 0.1641 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0059 | 0.1246 | 0.1734 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0059 | 0.1246 | 0.1734 |
Onchocerca volvulus | 0.0059 | 0.1246 | 1 | |
Echinococcus granulosus | neuroligin | 0.0059 | 0.1246 | 0.1734 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0882 | 0.1737 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5078 | 0.7364 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.1246 | 0.2454 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0489 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0703 | 0.102 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0059 | 0.1246 | 0.1734 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1248 | 0.1737 |
Echinococcus granulosus | acetylcholinesterase | 0.0177 | 0.5078 | 0.734 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5078 | 0.7364 |
Echinococcus multilocularis | acetylcholinesterase | 0.0177 | 0.5078 | 0.734 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0177 | 0.5078 | 0.7364 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6896 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.16 | 0.2321 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0059 | 0.1246 | 0.1734 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0642 | 0.0931 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0802 | 0.1163 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1246 | 0.1807 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1248 | 0.1737 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0059 | 0.1246 | 0.2454 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.1363 | 0.2683 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.033 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0567 | 0.0822 |
Brugia malayi | Carboxylesterase family protein | 0.0177 | 0.5078 | 0.731 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0802 | 0.1084 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0802 | 0.158 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0059 | 0.1246 | 0.1734 |
Brugia malayi | Carboxylesterase family protein | 0.0177 | 0.5078 | 0.731 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0802 | 0.158 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k3 (binding) | = 0.35 s-1 | Kinetic constant First order rate of inactivation (K3) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
k3 (binding) | = 0.35 s-1 | Kinetic constant First order rate of inactivation (K3) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
Ki (binding) | = 6.8 M-1 s-1 | Kinetic constant Apparent second order rate of inactivation (Ki) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
Ki (binding) | = 6.8 M-1 s-1 | Kinetic constant Apparent second order rate of inactivation (Ki) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
Ki (binding) | = 51 uM | Kinetic constant Apparent binding constant (Ki`) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
Ki (binding) | = 51 uM | Kinetic constant Apparent binding constant (Ki`) for the inhibition of papain conducted in 0.1 M phosphate, pH 6.8, at 30 degree C | ChEMBL. | 8765519 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.