Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.3658 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3596 | 0.982 | 0.9706 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3596 | 0.982 | 0.9706 |
Mycobacterium ulcerans | hypothetical protein | 0.2159 | 0.5636 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2159 | 0.5636 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3596 | 0.982 | 0.9706 |
Loa Loa (eye worm) | hypothetical protein | 0.3596 | 0.982 | 0.9812 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3658 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3596 | 0.982 | 0.9706 |
Onchocerca volvulus | 0.3658 | 1 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.2159 | 0.5636 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3658 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3658 | 1 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3658 | 1 | 1 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3658 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2159 | 0.5636 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2097 | 0.5456 | 0.5241 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3658 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2159 | 0.5636 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.0453 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 uM | Inhbition of purified alpha4 beta1 binding to VCAM-1 was determined in an ELISA assay. | ChEMBL. | 9341911 |
IC50 (binding) | = 1.3 uM | Inhbition of purified alpha4 beta1 binding to VCAM-1 was determined in an ELISA assay. | ChEMBL. | 9341911 |
IC50 (binding) | = 40 uM | Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1. | ChEMBL. | 9341911 |
IC50 (binding) | = 40 uM | Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1. | ChEMBL. | 9341911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.