Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | plasmepsin II | 0.0058 | 0.221 | 0.6554 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0026 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0026 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0075 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0058 | 0.221 | 0.6554 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0058 | 0.221 | 0.6554 |
Treponema pallidum | NADH oxidase | 0.0026 | 0 | 0.5 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0058 | 0.221 | 0.6554 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0075 | 0.3372 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0171 | 1 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0058 | 0.221 | 1 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0058 | 0.221 | 0.6554 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0026 | 0 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0058 | 0.221 | 0.6554 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0026 | 0 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0058 | 0.221 | 0.6554 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.221 | 0.221 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0075 | 0.3372 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0026 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0075 | 0.3372 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0058 | 0.221 | 0.6554 |
Plasmodium vivax | glutathione reductase, putative | 0.0075 | 0.3372 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0075 | 0.3372 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0075 | 0.3372 | 1 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0058 | 0.221 | 0.6554 |
Trypanosoma brucei | trypanothione reductase | 0.0075 | 0.3372 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0026 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0075 | 0.3372 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0075 | 0.3372 | 1 |
Brugia malayi | glutathione reductase | 0.0075 | 0.3372 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0075 | 0.3372 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0075 | 0.3372 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0075 | 0.3372 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0058 | 0.221 | 0.6554 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0026 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0075 | 0.3372 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0828 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.