Detailed information for compound 1880215

Basic information

Technical information
  • TDR Targets ID: 1880215
  • Name: N-[(4-dimethylaminophenyl)methylideneamino]-2 -pentylcyclopropane-1-carboxamide
  • MW: 301.426 | Formula: C18H27N3O
  • H donors: 1 H acceptors: 1 LogP: 4.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC1CC1C(=O)N/N=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C18H27N3O/c1-4-5-6-7-15-12-17(15)18(22)20-19-13-14-8-10-16(11-9-14)21(2)3/h8-11,13,15,17H,4-7,12H2,1-3H3,(H,20,22)/b19-13+
  • InChiKey: HJUUUGDRRUIJBR-CPNJWEJPSA-N  

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Synonyms

  • N-[(4-dimethylaminophenyl)methyleneamino]-2-pentyl-cyclopropane-1-carboxamide
  • N-[(4-dimethylaminophenyl)methyleneamino]-2-pentyl-1-cyclopropanecarboxamide
  • 2-amyl-N-[(4-dimethylaminobenzylidene)amino]cyclopropane-1-carboxamide
  • N-[(4-dimethylaminophenyl)methylideneamino]-2-pentyl-cyclopropane-1-carboxamide
  • A0202/0009020
  • N'-((E)-[4-(Dimethylamino)phenyl]methylidene)-2-pentylcyclopropanecarbohydrazide
  • N'-[4-(Dimethylamino)benzylidene]-2-pentyl-1-cyclopropanecarbohydrazide
  • MLS000544501
  • N'-[4-(dimethylamino)benzylidene]-2-pentylcyclopropanecarbohydrazide
  • SMR000163106

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus importin subunit beta 1 0.0035 0.0082 0.0001
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0639 0.1263
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0046 0.0091
Brugia malayi Heterochromatin protein 1 0.0084 0.0694 0.1292
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0599 0.0522
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0077 0.0601 0.1042
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0077 0.0601 0.1187
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0077 0.0601 0.1042
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0077 0.0601 0.1187
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Brugia malayi RNA, U transporter 1 0.0099 0.0879 0.1661
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0077 0.0601 0.0523
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0087 0.0081
Brugia malayi proteasome subunit alpha type 4 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0077 0.0601 0.1187
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0077 0.0601 0.1042
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0601 0.1187
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0077 0.0601 0.1042
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0436 0.5062 1
Giardia lamblia 20S proteasome alpha subunit 4 0.0077 0.0601 0.1033
Echinococcus multilocularis proteasome (prosome, macropain) 0.0436 0.5062 0.5022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0639 0.1263
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.0071
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0077 0.0601 0.1187
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0077 0.0601 0.1042
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0077 0.0601 0.1187
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0179 0.1879 0.1813
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0077 0.0601 0.1187
Mycobacterium ulcerans proteasome PrcB 0.0436 0.5062 1
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0077 0.0601 0.1033
Toxoplasma gondii proteasome subunit beta type, putative 0.0436 0.5062 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Giardia lamblia 20S proteasome alpha subunit 3 0.0077 0.0601 0.1033
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0286 0.3204 0.633
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0077 0.0601 0.1105
Brugia malayi proteasome subunit alpha type 3 0.0077 0.0601 0.1105
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0258 0.0178
Onchocerca volvulus 0.0037 0.0109 0.007
Plasmodium vivax proteasome subunit beta type-6, putative 0.0077 0.0601 0.1042
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Plasmodium falciparum proteasome subunit beta type-4 0.0077 0.0601 0.1042
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0179 0.1879 0.1812
Toxoplasma gondii peptidase, T1 family protein 0.0077 0.0601 0.1042
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0077 0.0601 0.1042
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0077 0.0601 0.0523
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0077 0.0601 0.0523
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0436 0.5062 1
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0077 0.0601 0.0523
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0077 0.0601 0.1042
Leishmania major proteasome beta 2 subunit, putative 0.0179 0.1879 0.3711
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0077 0.0601 0.1187
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0222 0.0142
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0097 0.0015
Brugia malayi 20S proteasome alpha5 subunit 0.0077 0.0601 0.1105
Loa Loa (eye worm) PAS-3 protein 0.0077 0.0601 0.1105
Brugia malayi Pre-SET motif family protein 0.0251 0.2771 0.5432
Trypanosoma brucei proteasome beta 6 subunit 0.0286 0.3204 0.6296
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0639 0.0562
Trypanosoma cruzi 20S proteasome subunit 0.0179 0.1879 0.3711
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0639 0.0562
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0077 0.0601 0.1187
Brugia malayi Cytochrome P450 family protein 0.0067 0.0487 0.0879
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0599 0.0522
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0639 0.1263
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0286 0.3204 0.627
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0077 0.0601 0.1187
Mycobacterium ulcerans proteasome PrcA 0.0077 0.0601 0.1105
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0077 0.0601 0.1105
Echinococcus multilocularis snurportin 1 0.0372 0.4266 0.4219
Leishmania major proteasome alpha 1 subunit, putative 0.0077 0.0601 0.1187
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0077 0.0601 0.0523
Brugia malayi Importin beta-1 subunit 0.0035 0.0082 0.0071
Trypanosoma brucei proteasome beta 7 subunit 0.0077 0.0601 0.1105
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0179 0.1879 0.3608
Leishmania major proteasome beta 5 subunit, putative 0.0436 0.5062 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0397 0.07
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0077 0.0601 0.1187
Echinococcus granulosus proteasome subunit alpha type 2 0.0077 0.0601 0.0524
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0077 0.0601 0.1105
Brugia malayi Proteasome subunit alpha type 1 0.0077 0.0601 0.1105
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0599 0.0522
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0077 0.0601 0.0523
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0087 0.0005
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2771 0.5432
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0077 0.0601 0.0523
Giardia lamblia 20S proteasome alpha subunit 6 0.0077 0.0601 0.1033
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0397 0.07
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0077 0.0601 0.1187
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0077 0.0601 0.1042
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0077 0.0601 0.0523
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0639 0.1183
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0286 0.3204 0.3148
Plasmodium vivax proteasome subunit beta type-1, putative 0.0286 0.3204 0.627
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0077 0.0601 0.1042
Leishmania major proteasome beta 7 subunit, putative 0.0077 0.0601 0.1187
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0179 0.1879 0.1812
Plasmodium vivax proteasome subunit beta type-7, putative 0.0077 0.0601 0.1042
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0077 0.0601 0.0523
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0694 0.1372
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0787 0.0711
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0436 0.5062 0.5022
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0087 0.0006
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0179 0.1879 0.3711
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0077 0.0601 0.1187
Giardia lamblia 20S proteasome alpha subunit 5 0.0077 0.0601 0.1033
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0077 0.0601 0.1187
Brugia malayi jmjC domain containing protein 0.0115 0.1082 0.2064
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0077 0.0601 0.1042
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0286 0.3204 0.3149
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0268 0.0188
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0077 0.0601 0.1187
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0077 0.0601 0.1187
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0077 0.0601 0.0523
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0077 0.0601 0.1105
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0601 0.1187
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0599 0.0522
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0258 0.0179
Echinococcus granulosus chromobox protein 1 0.0084 0.0694 0.0619
Echinococcus granulosus proteasome subunit beta t family 0.0077 0.0601 0.0524
Brugia malayi Bromodomain containing protein 0.0035 0.0087 0.0081
Plasmodium vivax proteasome subunit beta type-5, putative 0.0436 0.5062 1
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0436 0.5062 1
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0077 0.0601 0.1187
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0097 0.0015
Leishmania major proteasome alpha 1 subunit, putative 0.0077 0.0601 0.1187
Schistosoma mansoni hypothetical protein 0.0035 0.0087 0.0005
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0077 0.0601 0.1042
Echinococcus granulosus Proteasome subunit alpha beta 0.0077 0.0601 0.0524
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0599 0.1103
Echinococcus multilocularis proteasome subunit beta type 6 0.0077 0.0601 0.0523
Echinococcus granulosus proteasome subunit beta type 7 0.0077 0.0601 0.0524
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0077 0.0601 0.1042
Brugia malayi proteasome subunit alpha type 6 0.0077 0.0601 0.1105
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0077 0.0601 0.0523
Leishmania major proteasome beta-1 subunit, putative 0.0077 0.0601 0.1187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0082 0.0071
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0639 0.1263
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0077 0.0601 0.1187
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0097 0.0031
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0077 0.0601 0.0523
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0077 0.0601 0.0523
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0694 0.1292
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0097 0.0015
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0077 0.0601 0.1105
Echinococcus multilocularis proteasome subunit beta type 7 0.0077 0.0601 0.0523
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0286 0.3204 0.633
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0552 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0064 0.0127
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0077 0.0601 0.1187
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0077 0.0601 0.1042
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0601 0.1187
Loa Loa (eye worm) hypothetical protein 0.0035 0.0087 0.0081
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0436 0.5062 1
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0436 0.5062 1
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0077 0.0601 0.0524
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0286 0.3204 0.633
Brugia malayi Proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0077 0.0601 0.1187
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0077 0.0601 0.1187
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0077 0.0601 0.1033
Echinococcus granulosus Proteasome subunit alpha type 7 0.0077 0.0601 0.0524
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0077 0.0601 0.1042
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.028 0.0619
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0077 0.0601 0.1033
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0077 0.0601 0.1187
Brugia malayi proteasome subunit beta type 1 0.0286 0.3204 0.6296
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0222 0.0143
Leishmania major proteasome beta 3 subunit, putative 0.0077 0.0601 0.1187
Echinococcus granulosus subfamily T1A non peptidase ue 0.0077 0.0601 0.0524
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0077 0.0601 0.1042
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0179 0.1879 0.3711
Brugia malayi proteasome subunit alpha type 2 0.0077 0.0601 0.1105
Giardia lamblia Proteasome subunit beta type 3 0.0077 0.0601 0.1033
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0601 0.1187
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0599 0.1103
Echinococcus granulosus chromobox protein 1 0.0084 0.0694 0.0619
Echinococcus granulosus proteasome subunit alpha type 6 0.0077 0.0601 0.0524
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0179 0.0098
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0077 0.0601 0.1187
Toxoplasma gondii proteasome subunit alpha1, putative 0.0077 0.0601 0.1042
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0179 0.0099
Giardia lamblia 20S proteasome alpha subunit 1 0.0077 0.0601 0.1033
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0599 0.0522
Giardia lamblia Proteasome subunit beta type 1 0.0286 0.3204 0.6266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0097 0.0102
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0077 0.0601 0.0523
Leishmania major cytochrome p450-like protein 0.0032 0.0046 0.0091
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0694 0.1372
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0077 0.0601 0.1105
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0077 0.0601 0.1042
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0487 0.0879
Schistosoma mansoni hypothetical protein 0.0372 0.4266 0.4219
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0639 0.0563
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0077 0.0601 0.1187
Brugia malayi Proteasome subunit alpha type 7-1 0.0077 0.0601 0.1105
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0599 0.1103
Echinococcus granulosus tar DNA binding protein 0.0076 0.0599 0.0523
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0179 0.1879 0.3608
Toxoplasma gondii proteasome beta subunit 0.0077 0.0601 0.1042
Echinococcus multilocularis peregrin 0.0035 0.0087 0.0005
Brugia malayi proteasome subunit alpha type 1 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0077 0.0601 0.1187
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0077 0.0601 0.1187
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0286 0.3204 0.3148
Leishmania major proteasome alpha 3 subunit, putative 0.0077 0.0601 0.1187
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0077 0.0601 0.1105
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0077 0.0601 0.1187
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0087 0.001
Giardia lamblia 20S proteasome alpha subunit 7 0.0077 0.0601 0.1033
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0179 0.1879 0.3711
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0235 0.0477
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0087 0.001
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0077 0.0601 0.1105
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0077 0.0601 0.1042
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0077 0.0601 0.1042
Leishmania major proteasome alpha 2 subunit, putative 0.0077 0.0601 0.1187
Giardia lamblia 20S proteasome alpha subunit 2 0.0077 0.0601 0.1033
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Brugia malayi Proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Plasmodium vivax proteasome subunit beta type-3, putative 0.0077 0.0601 0.1042
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0077 0.0601 0.0523
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0077 0.0601 0.1105
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0097 0.0017
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0077 0.0601 0.0523
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0077 0.0601 0.1187
Loa Loa (eye worm) hypothetical protein 0.0041 0.016 0.0228
Plasmodium falciparum proteasome subunit beta type-5 0.0436 0.5062 1
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0077 0.0601 0.1187
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0077 0.0601 0.0523
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0077 0.0601 0.5
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0436 0.5062 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0235 0.0464
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0599 0.0522
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0077 0.0601 0.1105
Trichomonas vaginalis chromobox protein, putative 0.0051 0.028 0.0552
Brugia malayi proteasome subunit beta type 3 0.0077 0.0601 0.1105
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.016 0.0228
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3202 0.6326
Echinococcus granulosus snurportin 1 0.0372 0.4266 0.422
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0097 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0087 0.0005
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0077 0.0601 0.0523
Loa Loa (eye worm) hypothetical protein 0.0037 0.0109 0.0124
Schistosoma mansoni chromobox protein 0.0084 0.0694 0.0618
Brugia malayi proteasome subunit beta type 2 0.0179 0.1879 0.3653
Leishmania major proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0179 0.0098
Schistosoma mansoni chromobox protein 0.0084 0.0694 0.0618
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0077 0.0601 0.0523
Plasmodium falciparum phd finger protein, putative 0.0035 0.0087 0.001
Trypanosoma brucei proteasome alpha 7 subunit 0.0077 0.0601 0.1105
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0397 0.07
Loa Loa (eye worm) hypothetical protein 0.006 0.0399 0.0703
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0087 0.001
Echinococcus multilocularis proteasome subunit alpha type 6 0.0077 0.0601 0.0523
Toxoplasma gondii proteasome subunit alpha type, putative 0.0077 0.0601 0.1042
Brugia malayi PHD-finger family protein 0.0035 0.0087 0.0081
Onchocerca volvulus 0.0286 0.3202 1
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0077 0.0601 0.1042
Plasmodium vivax proteasome subunit beta type-4, putative 0.0077 0.0601 0.1042
Brugia malayi RNA binding protein 0.0076 0.0599 0.1103
Echinococcus granulosus proteasome subunit beta type 6 0.0077 0.0601 0.0524
Leishmania major proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Loa Loa (eye worm) proteasome subunit beta type 1 0.0286 0.3204 0.6296
Echinococcus multilocularis chromobox protein 1 0.0084 0.0694 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0235 0.0464
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0077 0.0601 0.1187
Brugia malayi Proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0077 0.0601 0.1187
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0077 0.0601 0.1187
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0179 0.1879 0.1812
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0179 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0064 0.0127
Loa Loa (eye worm) RNA binding protein 0.0076 0.0599 0.1103
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0077 0.0601 0.1187
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0077 0.0601 0.1042
Onchocerca volvulus Notchless protein homolog 0.0077 0.0601 0.165
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0077 0.0601 0.1042
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0179 0.1879 0.3711
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0077 0.0601 0.1105
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0077 0.0601 0.0523
Trichomonas vaginalis chromobox protein, putative 0.0051 0.028 0.0552
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0077 0.0601 0.1042
Loa Loa (eye worm) proteasome subunit beta type 2 0.0179 0.1879 0.3653
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0077 0.0601 0.1187
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Echinococcus multilocularis chromobox protein 1 0.0084 0.0694 0.0618
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0077 0.0601 0.0524
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0082 0.0071
Onchocerca volvulus 0.005 0.0268 0.0583
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0077 0.0601 0.0523
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0436 0.5062 1
Brugia malayi Proteasome A-type and B-type family protein 0.0436 0.5062 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1082 0.1008
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4266 0.8413
Brugia malayi jmjC domain containing protein 0.0043 0.0179 0.0264
Toxoplasma gondii heat shock protein hslv, putative 0.0077 0.0601 0.1042
Brugia malayi Pre-SET motif family protein 0.0036 0.0097 0.0102
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0077 0.0601 0.1042
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Echinococcus granulosus proteasome prosome macropain 0.0436 0.5062 0.5022
Loa Loa (eye worm) proteasome subunit beta type 3 0.0077 0.0601 0.1105
Toxoplasma gondii proteasome subunit 0.0077 0.0601 0.1042
Echinococcus granulosus peregrin 0.0035 0.0087 0.0006
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0077 0.0601 0.1105
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0077 0.0601 0.1187
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0077 0.0601 0.1105
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0077 0.0601 0.1187
Giardia lamblia Proteasome subunit beta type 2 0.0179 0.1879 0.3602
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0639 0.1183
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1082 0.1009
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0077 0.0601 0.0523
Loa Loa (eye worm) hypothetical protein 0.006 0.0397 0.07
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Echinococcus multilocularis proteasome subunit alpha type 2 0.0077 0.0601 0.0523
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0286 0.3204 0.633
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0077 0.0601 0.0523
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0077 0.0601 0.1105
Leishmania major proteasome beta 2 subunit, putative 0.0077 0.0601 0.1187
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0179 0.1879 0.3653
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0179 0.1879 0.3608
Schistosoma mansoni hypothetical protein 0.0041 0.016 0.0079
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0077 0.0601 0.1187
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0077 0.0601 0.0523
Plasmodium vivax SET domain protein, putative 0.0036 0.0097 0.0031
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0436 0.5062 1
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0286 0.3204 0.633
Brugia malayi TAR-binding protein 0.0076 0.0599 0.1103
Brugia malayi chromobox protein homolog 3 0.0047 0.0235 0.0377
Loa Loa (eye worm) hypothetical protein 0.0047 0.0235 0.0377
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0077 0.0601 0.0524
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0179 0.0098
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0077 0.0601 0.1187
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0077 0.0601 0.1105
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0436 0.5062 1
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0077 0.0601 0.1042
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0286 0.3204 0.627
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1187
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0639 0.1183
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0046 0.0091
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0077 0.0601 0.1105
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0097 0.0015

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 1.77827941 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.818382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 3.548133892 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 8.912509381 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.4609 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 26.8545 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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