Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short chain dehydrogenase | 0.0557 | 1 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0279 | 0.3516 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 0.3516 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 0.3516 | 0.5 |
Brugia malayi | hypothetical protein | 0.0128 | 0 | 0.5 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 0.3516 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.28 uM | Inhibition of leukotriene A4 hydrolase in human recombinant assay | ChEMBL. | 12419366 |
IC50 (binding) | = 0.28 uM | Inhibition of leukotriene A4 hydrolase in human recombinant assay | ChEMBL. | 12419366 |
IC50 (functional) | = 0.29 uM | Inhibition of leukotriene B4 production in human whole blood | ChEMBL. | 12419366 |
IC50 (functional) | = 0.29 uM | Inhibition of leukotriene B4 production in human whole blood | ChEMBL. | 12419366 |
Inhibition (functional) | = 80 % | Ex vivo inhibition of LTB4 production in mouse whole blood at 10 mg/kg | ChEMBL. | 12419366 |
Inhibition (functional) | = 80 % | Ex vivo inhibition of LTB4 production in mouse whole blood at 10 mg/kg | ChEMBL. | 12419366 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12419366 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.