Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | fibroinase | 0.0053 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0582 | 0.2606 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0037 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0157 | 1 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0053 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0157 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0053 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0037 | 0.0582 | 0.2606 |
Entamoeba histolytica | cysteine protease, putative | 0.0053 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0053 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0053 | 0.1828 | 0.1828 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0053 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin F homolog | 0.0053 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0053 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0157 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0058 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0037 | 0.0582 | 0.0582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0053 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2232 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2232 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0037 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0053 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0582 | 0.0582 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0058 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0157 | 1 | 1 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0053 | 0.1828 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0053 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0058 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0037 | 0.0582 | 0.0582 |
Brugia malayi | Cathepsin L-like precursor | 0.0037 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | cathepsin B | 0.0058 | 0.2232 | 0.1752 |
Brugia malayi | cathepsin L-like precursor | 0.0037 | 0.0582 | 0.0582 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0053 | 0.1828 | 0.1323 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0053 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0058 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0053 | 0.1828 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0053 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.1828 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0053 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0053 | 0.1828 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.1828 | 0.1828 |
Toxoplasma gondii | cathepsin B | 0.0058 | 0.2232 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0053 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0058 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0157 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0053 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0037 | 0.0582 | 0.0582 |
Plasmodium vivax | vivapain-2 | 0.0053 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0053 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin b | 0.0157 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0157 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0053 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0058 | 0.2232 | 0.2232 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0157 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0053 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0053 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0053 | 0.1828 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.07 uM | Growth inhibition of human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 24650643 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.