TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.475 | Formula: C24H28O7
H donors: 0 H acceptors: 2 LogP: 4.59 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(C)cc2c1Oc1ccc(c(c1C(=O)OC2)OC)[C@@H](OC(=O)C)CC(C)C
InChi: 1S/C24H28O7/c1-13(2)9-19(30-15(4)25)17-7-8-18-21(23(17)28-6)24(26)29-12-16-10-14(3)11-20(27-5)22(16)31-18/h7-8,10-11,13,19H,9,12H2,1-6H3/t19-/m0/s1
InChiKey: KCGSFIODCSTCQI-IBGZPJMESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Brugia malayi	hypothetical protein	0.009	0.0041	0.0042
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.009	0.0041	0.0042
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Leishmania major	protein kinase, putative	0.009	0.0041	0.5
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Onchocerca volvulus		0.009	0.0041	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0201	0.0239	1
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Leishmania major	hypothetical protein, conserved	0.009	0.0041	0.5
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	C-terminal src kinase protein 1	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.009	0.0041	0.0042
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Plasmodium vivax	tyrosine kinase-like protein, putative	0.009	0.0041	0.5
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Receptor family ligand binding region containing protein	0.009	0.0041	0.0042
Brugia malayi	Protein kinase domain containing protein	0.557	0.9839	1
Entamoeba histolytica	receptor protein kinase, putative	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	SH2 domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.557	0.9839	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.557	0.9839	1
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/CSK protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	serine/threonine protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Onchocerca volvulus		0.009	0.0041	0.5
Trypanosoma brucei	protein kinase, putative	0.009	0.0041	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.009	0.0041	0.0041
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.009	0.0041	0.5
Loa Loa (eye worm)	TK/ALK protein kinase	0.009	0.0041	0.0035
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Plasmodium falciparum	tyrosine kinase-like protein	0.009	0.0041	0.5
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Toxoplasma gondii	STE kinase	0.009	0.0041	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.009	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	RGC/RGC protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	protein tyrosine kinase	0.009	0.0041	0.0041
Plasmodium falciparum	tyrosine kinase-like protein	0.009	0.0041	0.5
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Brugia malayi	bone morphogenetic protein type 1 receptor	0.009	0.0041	0.0042
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.009	0.0041	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK/ROR protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	hypothetical protein, conserved	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Onchocerca volvulus		0.009	0.0041	0.5
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Plasmodium falciparum	protein kinase, putative	0.009	0.0041	0.5
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Brugia malayi	SRC-1	0.009	0.0041	0.0042
Brugia malayi	SH2 domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0201	0.0239	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	hypothetical protein	0.009	0.0041	0.0041
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.009	0.0041	0.5
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trypanosoma brucei	Pseudokinase, putative	0.009	0.0041	1
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosin kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/Met protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Loa Loa (eye worm)	SRC-1	0.009	0.0041	0.0035
Entamoeba histolytica	tyrosin kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK/RYK protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.009	0.0041	0.5
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	RGC/RGC protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0195	0.0228	0.9555
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.013	0.0112	0.0114
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK/EGFR protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Onchocerca volvulus		0.009	0.0041	0.5
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	RGC/RGC protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/ABL protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TK/EPH protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Schistosoma mansoni	serine/threonine RGC	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Onchocerca volvulus		0.009	0.0041	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0089	0.0039	0.1637
Loa Loa (eye worm)	TK/INSR protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.016	0.0166	0.6931
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0378	0.0555	0.0525
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0097	0.0053	1
Brugia malayi	protein-tyrosine kinase	0.009	0.0041	0.0042
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.009	0.0041	0.5
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.013	0.0112	0.0108
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	hypothetical protein	0.009	0.0041	0.0042
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.009	0.0041	0.0035
Brugia malayi	integrin-linked kinase	0.009	0.0041	0.0042
Onchocerca volvulus		0.009	0.0041	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.013	0.0112	0.0073
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0041	0.0041
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Brugia malayi	Furin-like cysteine rich region family protein	0.009	0.0041	0.0042
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosin kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	protein kinase atn1, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TK/DDR protein kinase	0.009	0.0041	0.0035
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.009	0.0041	0.0041
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0378	0.0555	0.0555
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Onchocerca volvulus		0.009	0.0041	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/ACK protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	Tyrosine-protein kinase abl-1	0.009	0.0041	0.0042
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TK family protein kinase	0.009	0.0041	0.1726
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0378	0.0555	0.0525
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Plasmodium vivax	tyrosine kinase-like protein, putative	0.009	0.0041	0.5
Plasmodium vivax	protein kinase, putative	0.009	0.0041	0.5
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	ephrin receptor	0.009	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0201	0.0239	1
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.009	0.0041	0.5
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	receptor protein kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Entamoeba histolytica	tyrosin kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.009	0.0041	0.0041
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	ankyrin repeat protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TKL/MLK/LZK protein kinase	0.557	0.9839	1
Toxoplasma gondii	protein kinase	0.009	0.0041	0.5
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0138	0.0127	0.5294
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	AGC family protein kinase	0.009	0.0041	0.1726
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.009	0.0041	0.0042
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0201	0.0239	1
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Onchocerca volvulus		0.009	0.0041	0.5
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	cysteine surface protein, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.557	0.9839	1
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.009	0.0041	0.0042
Plasmodium falciparum	protein kinase, putative	0.009	0.0041	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Plasmodium falciparum	protein kinase, putative	0.009	0.0041	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.009	0.0041	0.0042
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0041	0.0042
Brugia malayi	Guanylyl cyclase protein 23	0.009	0.0041	0.0042
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Leishmania major	protein kinase, putative	0.009	0.0041	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Tyrosine-protein kinase PR2	0.009	0.0041	0.0042
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Brugia malayi	Raf kinase	0.009	0.0041	0.0042
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	hypothetical protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Onchocerca volvulus		0.009	0.0041	0.5
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0201	0.0239	1
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.009	0.0041	0.0035
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine protein kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0138	0.0127	0.5294
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.009	0.0041	0.0041
Trypanosoma brucei	Flagellum attachment zone protein 20	0.009	0.0041	1
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Brugia malayi	Immunoglobulin I-set domain containing protein	0.009	0.0041	0.0042
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0201	0.0239	1
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.009	0.0041	1
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Schistosoma mansoni	ephrin receptor	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0177	0.0196	0.0199
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Brugia malayi	hypothetical protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035
Brugia malayi	ephrin receptor 1 precursor	0.009	0.0041	0.0042
Trypanosoma cruzi	protein kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.013	0.0112	0.0073
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Entamoeba histolytica	serine/threonine kinase, putative	0.009	0.0041	0.1726
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.009	0.0041	0.5
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	CAMK family protein kinase	0.009	0.0041	0.1726
Onchocerca volvulus		0.009	0.0041	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	ankyrin repeat protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.009	0.0041	0.0035
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Brugia malayi	Protein kinase domain containing protein	0.009	0.0041	0.0042
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Toxoplasma gondii	protein kinase domain-containing protein	0.009	0.0041	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.009	0.0041	0.1726
Trypanosoma cruzi	protein kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	RGC/RGC protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	phosphatidylinositol 3	0.0337	0.0482	0.0484
Trichomonas vaginalis	STE family protein kinase	0.009	0.0041	0.1726
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0201	0.0239	0.0243
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Loa Loa (eye worm)	hypothetical protein	0.557	0.9839	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	tyrosine kinase, putative	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK/FER protein kinase	0.009	0.0041	0.0035
Entamoeba histolytica	protein kinase, putative	0.009	0.0041	0.1726
Schistosoma mansoni	tyrosine kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Trichomonas vaginalis	TKL family protein kinase	0.009	0.0041	0.1726
Entamoeba histolytica	hypothetical protein	0.016	0.0166	0.6931
Schistosoma mansoni	protein kinase	0.009	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.009	0.0041	0.1726
Loa Loa (eye worm)	TK protein kinase	0.009	0.0041	0.0035

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 uM	Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue	ChEMBL.	No reference
IC50 (binding)	= 21 uM	Compound was tested for its ability to inhibit binding of Oxytocin to its Oxytocin receptor in rat uterine tissue	ChEMBL.	No reference
IC50 (binding)	> 100 uM	Compound was tested for its ability to inhibit binding of arginine vasopressin to Vasopressin receptor (V1 subtype)	ChEMBL.	No reference
IC50 (binding)	> 100 uM	Compound was tested for its ability to inhibit binding of arginine vasopressin to Vasopressin receptor (V1 subtype)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL326085

Bibliographic References

No literature references available for this target.

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Detailed information for compound 188471