Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0172 | 0.2351 | 0.2351 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0472 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0472 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0141 | 0.1575 | 0.1575 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0141 | 0.1575 | 1 |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0141 | 0.1575 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0141 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0295 | 0.5486 | 0.5486 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0099 | 0.0501 | 0.2131 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0172 | 0.2351 | 0.2351 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0472 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0141 | 0.1575 | 0.1575 |
Giardia lamblia | Cathepsin B precursor | 0.0172 | 0.2351 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0141 | 0.1575 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0172 | 0.2351 | 0.1948 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0172 | 0.2351 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Onchocerca volvulus | Cathepsin F homolog | 0.0141 | 0.1575 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0172 | 0.2351 | 0.4286 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Plasmodium vivax | vivapain-2 | 0.0141 | 0.1575 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0141 | 0.1575 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0172 | 0.2351 | 0.5 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.1575 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0141 | 0.1575 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0141 | 0.1575 | 0.1575 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0172 | 0.2351 | 0.1985 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0141 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0099 | 0.0501 | 0.0501 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0099 | 0.0501 | 0.2131 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0295 | 0.5486 | 0.5486 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Plasmodium vivax | vivapain-2 | 0.0141 | 0.1575 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0472 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0099 | 0.0501 | 0.0501 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0141 | 0.1575 | 1 |
Echinococcus granulosus | cathepsin b | 0.0472 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0253 | 0.4412 | 0.4412 |
Echinococcus granulosus | cathepsin b | 0.0472 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0172 | 0.2351 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0472 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0141 | 0.1575 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0141 | 0.1575 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0472 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0172 | 0.2351 | 0.5 |
Loa Loa (eye worm) | ctsf protein | 0.0141 | 0.1575 | 0.113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0099 | 0.0501 | 0.0501 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0191 | 0.2838 | 0.2838 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0141 | 0.1575 | 0.1575 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1575 | 0.113 |
Echinococcus granulosus | cathepsin l1 | 0.0141 | 0.1575 | 0.1575 |
Echinococcus granulosus | cathepsin l1 | 0.0099 | 0.0501 | 0.0501 |
Leishmania major | cathepsin L-like protease | 0.0295 | 0.5486 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Leishmania major | cathepsin L-like protease | 0.0295 | 0.5486 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0295 | 0.5486 | 0.5486 |
Echinococcus multilocularis | cysteine protease | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Loa Loa (eye worm) | fibroinase | 0.0141 | 0.1575 | 0.113 |
Brugia malayi | cathepsin L-like precursor | 0.0099 | 0.0501 | 0.0501 |
Echinococcus multilocularis | cathepsin b | 0.0472 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Leishmania major | cathepsin L-like protease | 0.0295 | 0.5486 | 1 |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Onchocerca volvulus | 0.0141 | 0.1575 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0099 | 0.0501 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0295 | 0.5486 | 0.5486 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0141 | 0.1575 | 0.1575 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.1575 | 0.6698 |
Brugia malayi | Cathepsin L-like precursor | 0.0141 | 0.1575 | 0.1575 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0099 | 0.0501 | 0.0501 |
Loa Loa (eye worm) | cysteine protease | 0.0141 | 0.1575 | 0.113 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0141 | 0.1575 | 0.113 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0295 | 0.5486 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Escherichia coli assessed as growth inhibition after 7 days by microtiter plate assay | ChEMBL. | 24684842 |
MIC (functional) | > 5.32 uM | Antibacterial activity against 0.5 ug/ml Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 7 days by microtiter plate assay | ChEMBL. | 24684842 |
MIC (functional) | > 5.32 uM | Antibacterial activity against 1 ug/ml Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as growth inhibition after 7 days by microtiter plate assay | ChEMBL. | 24684842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.