Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0164 | 1 | 0.5 |
Onchocerca volvulus | 0.0095 | 0.2315 | 0.3084 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0142 | 0.7506 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0164 | 1 | 1 |
Onchocerca volvulus | 0.0142 | 0.7506 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.7506 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.7506 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0117 | 0.4679 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0164 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0117 | 0.4679 | 0.5 |
Onchocerca volvulus | 0.0117 | 0.4679 | 0.6234 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0117 | 0.4679 | 0.6234 |
Echinococcus granulosus | thymidylate synthase | 0.0117 | 0.4679 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0164 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.0142 | 0.7506 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0164 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0142 | 0.7506 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0117 | 0.4679 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0117 | 0.4679 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0117 | 0.4679 | 0.6234 |
Brugia malayi | thymidylate synthase | 0.0117 | 0.4679 | 0.6234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.