Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0772 | 0.1258 | 0.1258 |
Entamoeba histolytica | cysteine protease, putative | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0768 | 0.1231 | 0.3116 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0772 | 0.1258 | 0.1258 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1127 | 0.3952 | 0.3952 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.1127 | 0.3952 | 0.3952 |
Loa Loa (eye worm) | fibroinase | 0.1127 | 0.3952 | 0.3103 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.1127 | 0.3952 | 0.3952 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1127 | 0.3952 | 0.3952 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1925 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1925 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1127 | 0.3952 | 0.3952 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.1258 | 0.003 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1925 | 1 | 1 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.1127 | 0.3952 | 0.3103 |
Giardia lamblia | Cathepsin B precursor | 0.0768 | 0.1231 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0768 | 0.1231 | 0.1231 |
Echinococcus multilocularis | cysteine protease | 0.1127 | 0.3952 | 0.3952 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1127 | 0.3952 | 0.3952 |
Echinococcus granulosus | cathepsin l1 | 0.1127 | 0.3952 | 0.3952 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0772 | 0.1258 | 0.1258 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.1127 | 0.3952 | 0.3952 |
Loa Loa (eye worm) | hypothetical protein | 0.1127 | 0.3952 | 0.3103 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0772 | 0.1258 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.1127 | 0.3952 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1925 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1127 | 0.3952 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1127 | 0.3952 | 0.3952 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1925 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.1127 | 0.3952 | 0.3103 |
Loa Loa (eye worm) | hypothetical protein | 0.1925 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0768 | 0.1231 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0772 | 0.1258 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.1127 | 0.3952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.1258 | 0.003 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.1127 | 0.3952 | 0.3952 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1925 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0772 | 0.1258 | 0.1258 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0768 | 0.1231 | 0.3116 |
Loa Loa (eye worm) | ctsf protein | 0.1127 | 0.3952 | 0.3103 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Loa Loa (eye worm) | cysteine protease | 0.1127 | 0.3952 | 0.3103 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.1127 | 0.3952 | 0.3952 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0768 | 0.1231 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0768 | 0.1231 | 0.1231 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0772 | 0.1258 | 0.1258 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Brugia malayi | Cathepsin L-like precursor | 0.0772 | 0.1258 | 0.1258 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Leishmania major | cysteine peptidase A (CPA) | 0.1127 | 0.3952 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1127 | 0.3952 | 0.3952 |
Brugia malayi | cathepsin L-like precursor | 0.0772 | 0.1258 | 0.1258 |
Echinococcus granulosus | cathepsin b | 0.1925 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0772 | 0.1258 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.1127 | 0.3952 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1127 | 0.3952 | 0.3952 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1127 | 0.3952 | 0.3952 |
Onchocerca volvulus | Cathepsin F homolog | 0.1127 | 0.3952 | 1 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.1127 | 0.3952 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.1127 | 0.3952 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.1127 | 0.3952 | 1 |
Onchocerca volvulus | 0.1127 | 0.3952 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.1127 | 0.3952 | 1 |
Leishmania major | cathepsin L-like protease | 0.1127 | 0.3952 | 1 |
Plasmodium vivax | vivapain-2 | 0.1127 | 0.3952 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.1127 | 0.3952 | 0.3952 |
Loa Loa (eye worm) | hypothetical protein | 0.0772 | 0.1258 | 0.003 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.1127 | 0.3952 | 0.3952 |
Plasmodium vivax | vivapain-2 | 0.1127 | 0.3952 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1925 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1925 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.1127 | 0.3952 | 0.3952 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.