Detailed information for compound 1888087

Basic information

Technical information
  • TDR Targets ID: 1888087
  • Name: 2-(6-methoxy-2-methylquinolin-4-yl)sulfanyl-N -[(2-methoxynaphthalen-1-yl)methylideneamino] acetamide
  • MW: 445.533 | Formula: C25H23N3O3S
  • H donors: 1 H acceptors: 2 LogP: 5.27 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c(SCC(=O)N/N=C/c1c(OC)ccc3c1cccc3)cc(n2)C
  • InChi: 1S/C25H23N3O3S/c1-16-12-24(20-13-18(30-2)9-10-22(20)27-16)32-15-25(29)28-26-14-21-19-7-5-4-6-17(19)8-11-23(21)31-3/h4-14H,15H2,1-3H3,(H,28,29)/b26-14+
  • InChiKey: BWUKOBODZHJCND-VULFUBBASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(6-methoxy-2-methyl-4-quinolyl)sulfanyl]-N-[(2-methoxy-1-naphthyl)methyleneamino]acetamide
  • 2-[(6-methoxy-2-methyl-4-quinolyl)thio]-N-[(2-methoxy-1-naphthyl)methyleneamino]acetamide
  • 2-(6-methoxy-2-methyl-quinolin-4-yl)sulfanyl-N-[(2-methoxynaphthalen-1-yl)methylideneamino]ethanamide
  • BAS 02379916
  • (6-Methoxy-2-methyl-quinolin-4-ylsulfanyl)-acetic acid (2-methoxy-naphthalen-1-ylmethylene)-hydrazide
  • MLS000553005
  • SMR000177587

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase eta, putative 0.0054 0.7086 0.7086
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0752 0.1062
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.2432 0.2432
Echinococcus granulosus dna polymerase kappa 0.0023 0.2432 0.1816
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0752 0.1062
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.7086 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Schistosoma mansoni aldehyde dehydrogenase 0.0073 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0752 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 1 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.5662 0.5309
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2432 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.4654 0.6568
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 1 1
Trypanosoma brucei unspecified product 0.0016 0.1337 0.1887
Brugia malayi nuclear hormone receptor 0.0012 0.0752 0.1062
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0752 0.0752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0752 0.1062
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.5662 0.5309
Echinococcus multilocularis dna polymerase eta 0.0054 0.7086 0.6849
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0752 0.0752
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.2432 0.2432
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.5662 0.5309
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.5662 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.5662 0.5309
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0752 0.0752
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0752 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.2432 0.1816
Echinococcus granulosus dna polymerase eta 0.0054 0.7086 0.6849
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.2432 0.3432
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Brugia malayi steroid hormone receptor 0.0012 0.0752 0.1062
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.2432 0.3432
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.2432 0.2432
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0752 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0752 0.1062
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0752 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0752 0.1062
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0752 0.0752
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2432 0.3432
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.5662 0.7991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0752 0.1062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0752 0.1062
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.2432 0.2432
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0752 0.1062
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0752 0.0752
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0752 0.1062
Onchocerca volvulus 0.0012 0.0752 0.5
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.5662 0.7991
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0752 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0752 0.1062
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0752 0.1062
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.7086 1
Leishmania major DNA polymerase kappa, putative 0.0023 0.2432 0.2432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1337 0.1887
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0752 0.1062
Toxoplasma gondii aldehyde dehydrogenase 0.0073 1 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.5662 0.7991
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.5662 1
Schistosoma mansoni DNA polymerase eta 0.0054 0.7086 0.7086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.5662 1
Trypanosoma brucei unspecified product 0.0016 0.1337 0.1887
Brugia malayi nuclear receptor NHR-88 0.0012 0.0752 0.1062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0752 0.1062
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0752 0.1062
Plasmodium vivax DNA repair protein REV1, putative 0.0007 0 0.5
Schistosoma mansoni aldehyde dehydrogenase 0.0073 1 1
Echinococcus multilocularis dna polymerase kappa 0.0023 0.2432 0.1816
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.2432 0.1816
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Loa Loa (eye worm) hypothetical protein 0.0054 0.7086 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.2432 0.3432
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.2432 0.2432
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0752 0.1062
Brugia malayi ecdysteroid receptor 0.0012 0.0752 0.1062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0752 0.0752
Plasmodium falciparum DNA repair protein REV1, putative 0.0007 0 0.5
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.5662 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0752 0.1062
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.5662 0.5662
Trypanosoma brucei unspecified product 0.0023 0.2432 0.3432
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0752 0.0752
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.7086 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 1 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.5662 0.5662
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.5662 0.5309
Loa Loa (eye worm) hypothetical protein 0.0012 0.0752 0.1062
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1337 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.2432 0.3432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0752 0.1062
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0752 0.0752
Schistosoma mansoni coup transcription factor 0.0012 0.0752 0.0752
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.5662 0.7991
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0752 0.1062
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.1337 0.1887
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.5662 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0752 0.1062
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0752 0.0752
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0752 0.0752
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 1 1
Leishmania major DNA polymerase eta, putative 0.0038 0.4654 0.4654
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.5662 0.5662
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0752 0.0752
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0752 0.1062
Giardia lamblia DINP protein human, muc B family 0.0023 0.2432 0.4295
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0752 0.1062
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.4654 0.4654
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.5662 0.5309
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0752 0.1062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0045 0.5662 0.7991

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7943 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2281, AID463106, AID463254] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter. (Class of assay: confirmatory) [Related pubchem assays: 2281 (Summary of qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a), 463106 (LOPAC Validation Assay for Inhibitors of Ubiquitin-specific Protease USP2a)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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