Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | 0.0287 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2558 | 0.2689 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.1078 | 0.0943 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.001 | 0.0203 | 0.0519 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0037 | 0.1153 | 0.4346 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0012 | 0.0277 | 0.0318 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0129 | 0.0129 |
Onchocerca volvulus | 0.0037 | 0.1153 | 0.0084 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1153 | 0.1031 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0037 | 0.1153 | 0.4036 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0035 | 0.108 | 0.3723 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0067 | 0.2223 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Plasmodium vivax | SET domain protein, putative | 0.0037 | 0.1153 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1148 | 0.4325 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0075 | 0.2501 | 0.9771 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0037 | 0.1153 | 0.4036 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.1148 | 0.4014 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.1078 | 0.0948 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2558 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0037 | 0.1153 | 0.1036 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0037 | 0.1153 | 0.4346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0012 | 0.0277 | 0.0318 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2558 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2558 | 0.2685 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2558 | 0.2685 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Brugia malayi | Pre-SET motif family protein | 0.0252 | 0.8771 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.1078 | 0.4043 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.1148 | 0.4014 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0252 | 0.8771 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0037 | 0.1153 | 0.4346 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0037 | 0.1153 | 0.4036 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0129 | 0.0129 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2558 | 0.2685 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0129 | 0.0129 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2558 | 0.2689 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.1148 | 0.4325 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0037 | 0.1153 | 0.4346 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2558 | 0.2689 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2558 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3162 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.