Detailed information for compound 1888402

Basic information

Technical information
  • TDR Targets ID: 1888402
  • Name: (E)-[4-(methylthio)benzylidene]-(4-phenylpipe razin-1-yl)amine
  • MW: 311.444 | Formula: C18H21N3S
  • H donors: 0 H acceptors: 0 LogP: 4.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)/C=N/N1CCN(CC1)c1ccccc1
  • InChi: 1S/C18H21N3S/c1-22-18-9-7-16(8-10-18)15-19-21-13-11-20(12-14-21)17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3/b19-15+
  • InChiKey: FEUJFHLHUSWSKD-XDJHFCHBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [4-(methylthio)benzylidene]-(4-phenylpiperazin-1-yl)amine
  • ZINC05009130
  • STOCK3S-58863
  • N-[4-(methylthio)benzylidene]-4-phenyl-1-piperazinamine
  • SMR000267601
  • MLS000683257
  • Oprea1_566054

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0183 0.1487
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0034 0.0191 0.1556
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Onchocerca volvulus 0.0118 0.1228 0.5405
Schistosoma mansoni cathepsin F (C01 family) 0.0084 0.0807 0.0807
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0118 0.1228 1
Echinococcus granulosus cathepsin L 0.0068 0.0611 0.0611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Brugia malayi Muscleblind-like protein 0.0158 0.1716 0.2755
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0611 0.087
Echinococcus multilocularis muscleblind protein 1 0.0158 0.1716 0.1716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Giardia lamblia Pyruvate kinase 0.0035 0.0211 0.1066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Echinococcus granulosus jumonji domain containing protein 0.0046 0.0341 0.0341
Echinococcus multilocularis cathepsin b 0.0504 0.5964 0.5964
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0034 0.0191 0.0153
Echinococcus granulosus cysteine protease 0.0068 0.0611 0.0611
Onchocerca volvulus 0.0034 0.0191 0.007
Brugia malayi intermediate filament protein 0.0033 0.0177 0.013
Brugia malayi fibroinase precursor 0.0034 0.0191 0.0153
Schistosoma mansoni cathepsin s 0.0034 0.0198 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Trypanosoma brucei cysteine peptidase C (CPC) 0.0179 0.1977 1
Schistosoma mansoni hypothetical protein 0.0179 0.1977 0.1977
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0045 0.0332 0.168
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.007 0.007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.0286 0.3281 0.5495
Giardia lamblia Cathepsin L-like protease 0.0034 0.0191 0.0966
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0397 0.0397
Schistosoma mansoni cathepsin S (C01 family) 0.0034 0.0191 0.0191
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0177 0.013
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.005 0.0397 0.0654
Loa Loa (eye worm) hypothetical protein 0.0191 0.212 0.3547
Onchocerca volvulus 0.0084 0.0807 0.3242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0371 0.0371
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Brugia malayi Cathepsin L-like precursor 0.0084 0.0807 0.1205
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0397 0.0654
Schistosoma mansoni cathepsin C 0.0034 0.0191 0.0191
Brugia malayi Papain family cysteine protease containing protein 0.0118 0.1228 0.1921
Echinococcus multilocularis cathepsin L cysteine protease 0.0118 0.1228 0.1228
Schistosoma mansoni hypothetical protein 0.0133 0.1411 0.1411
Onchocerca volvulus Alhambra homolog 0.0033 0.0183 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Schistosoma mansoni hypothetical protein 0.0058 0.0492 0.0492
Trypanosoma cruzi cruzipain precursor, putative 0.0034 0.0198 0.0012
Leishmania major hypothetical protein, conserved 0.0045 0.0332 0.0687
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Brugia malayi cathepsin L-like precursor 0.0084 0.0807 0.1205
Echinococcus granulosus geminin 0.0179 0.1977 0.1977
Schistosoma mansoni intermediate filament proteins 0.0033 0.0177 0.0177
Echinococcus multilocularis cathepsin b 0.0504 0.5964 0.5964
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0034 0.0198 0.0165
Schistosoma mansoni survival motor neuron protein 0.0058 0.0492 0.0492
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Echinococcus multilocularis jumonji domain containing protein 0.0046 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0035 0.0211 0.0342
Brugia malayi PHD-finger family protein 0.0033 0.0183 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0807 0.3452
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0244
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0552 0.0552
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0183 0.0924
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0034 0.0191 0.0966
Giardia lamblia Hypothetical protein 0.0034 0.0191 0.0966
Leishmania major cysteine peptidase A (CPA) 0.0118 0.1228 0.5758
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0034 0.0191 0.1556
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0122
Echinococcus multilocularis phd:f box containing protein 0.0045 0.0332 0.0332
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0238 0.2692 0.2692
Echinococcus granulosus jumonji domain containing 1A 0.0045 0.0332 0.0332
Echinococcus multilocularis lamin 0.0033 0.0177 0.0177
Giardia lamblia PHD finger protein 15 0.0033 0.0183 0.0924
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0211 0.0034
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0046 0.0065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Schistosoma mansoni hypothetical protein 0.0033 0.0183 0.0183
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0034 0.0191 0.1556
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Plasmodium falciparum serine repeat antigen 8 0.0034 0.0191 0.1556
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Echinococcus granulosus cathepsin l1 0.0084 0.0807 0.0807
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Brugia malayi mbt repeat family protein 0.005 0.0397 0.0504
Echinococcus multilocularis musashi 0.0033 0.0177 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0611 0.2268
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0482 0.0482
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0183 0.0183
Echinococcus multilocularis jumonji domain containing 1A 0.0045 0.0332 0.0332
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0177 0.0286
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0191 0.0309
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Schistosoma mansoni lamin 0.0033 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Echinococcus granulosus cathepsin L cysteine protease 0.0068 0.0611 0.0611
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0371 0.0461
Echinococcus granulosus lamin dm0 0.0033 0.0177 0.0177
Plasmodium falciparum serine repeat antigen 1 0.0034 0.0191 0.1556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1543 0.1543
Echinococcus multilocularis pyruvate kinase 0.0035 0.0211 0.0211
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1543 0.1543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.0807 0.3452
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0371 0.0371
Echinococcus granulosus cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Onchocerca volvulus 0.0118 0.1228 0.5405
Loa Loa (eye worm) hypothetical protein 0.0158 0.1716 0.2869
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0211 0.011
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0198 0.0321
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0191 0.1556
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0034 0.0191 0.1556
Echinococcus multilocularis tumor protein p63 0.0357 0.4162 0.4162
Echinococcus multilocularis protein patched 0.0051 0.0404 0.0404
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Giardia lamblia Encystation-specific protease 0.0034 0.0191 0.0966
Loa Loa (eye worm) fibroinase 0.0118 0.1228 0.2049
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0183 0.0183
Echinococcus granulosus pyruvate kinase 0.0035 0.0211 0.0211
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0482 0.0482
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0199 0.2217 0.2217
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0034 0.0191 0.0191
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1236 1
Toxoplasma gondii cathepsin B 0.0179 0.1977 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0198 0.0165
Brugia malayi cathepsin B-like cysteine proteinase 0.0504 0.5964 1
Echinococcus granulosus intermediate filament protein 0.0033 0.0177 0.0177
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0211 0.0034
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.075 0.075
Schistosoma mansoni jumonji domain containing protein 0.0215 0.2419 0.2419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax serine-repeat antigen (SERA) 0.0034 0.0191 0.1556
Echinococcus multilocularis peregrin 0.0035 0.0213 0.0213
Brugia malayi Bromodomain containing protein 0.0035 0.0213 0.0191
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.007 0.007
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3281 0.3281
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Plasmodium falciparum pyruvate kinase 0.0035 0.0211 0.1716
Brugia malayi cathepsin L precursor 0.0034 0.0191 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Echinococcus granulosus lysine specific demethylase 6a 0.0045 0.0332 0.0332
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0211 0.011
Brugia malayi N-terminal motif family protein 0.0191 0.212 0.3444
Brugia malayi jmjC domain containing protein 0.0171 0.1881 0.3036
Echinococcus multilocularis pyruvate kinase 0.0028 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0179 0.1977 0.1977
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0191 0.0153
Echinococcus multilocularis cysteine protease 0.0118 0.1228 0.1228
Entamoeba histolytica cysteine proteinase, putative 0.0118 0.1228 0.9925
Plasmodium falciparum JmjC domain-containing protein, putative 0.0045 0.0332 0.2705
Brugia malayi Bromodomain containing protein 0.0079 0.0751 0.1109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0211 0.1716
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0404 0.0404
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0034 0.0191 0.1556
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0045 0.0331 0.0544
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Plasmodium vivax JmjC domain containing protein 0.0045 0.0332 0.2705
Echinococcus granulosus expressed conserved protein 0.0112 0.1148 0.1148
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni jumonji/arid domain-containing protein 0.0171 0.1881 0.1881
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Echinococcus granulosus zinc finger protein 0.0021 0.0032 0.0032
Echinococcus multilocularis lamin dm0 0.0033 0.0177 0.0177
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0211 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Onchocerca volvulus 0.0118 0.1228 0.5405
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.1411 0.1411
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.075 0.075
Echinococcus multilocularis pyruvate kinase 0.0035 0.0211 0.0211
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Schistosoma mansoni cathepsin B (C01 family) 0.0034 0.0191 0.0191
Onchocerca volvulus Cathepsin L homolog 0.0118 0.1228 0.5405
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.008 0.0122
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.075 0.075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0034 0.0191 0.0309
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Plasmodium falciparum cysteine proteinase falcipain 1 0.0068 0.0611 0.4979
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0052 0.042 0.0692
Giardia lamblia Hypothetical protein 0.0034 0.0191 0.0966
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0404 0.1191
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1862 0.1862
Loa Loa (eye worm) hypothetical protein 0.0119 0.1236 0.2063
Echinococcus granulosus cathepsin b 0.0504 0.5964 0.5964
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Loa Loa (eye worm) cathepsin B 0.0179 0.1977 0.3306
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0611 0.0728
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0191 0.0962
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0397 0.113
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0034 0.0191 0.1556
Trypanosoma cruzi cruzipain precursor, putative 0.0118 0.1228 0.1795
Loa Loa (eye worm) hypothetical protein 0.0041 0.0276 0.0451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax vivapain-2 0.0118 0.1228 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0118 0.1228 0.1228
Loa Loa (eye worm) hypothetical protein 0.0504 0.5964 1
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0397 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni hypothetical protein 0.0022 0.0046 0.0046
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Onchocerca volvulus 0.0052 0.042 0.1247
Echinococcus granulosus pyruvate kinase 0.0035 0.0211 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus multilocularis zinc finger protein 0.0021 0.0032 0.0032
Echinococcus granulosus lamin 0.0033 0.0177 0.0177
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Entamoeba histolytica cysteine proteinase 1, putative 0.0068 0.0611 0.4596
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1236 0.1236
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0546
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0371 0.0612
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Loa Loa (eye worm) hypothetical protein 0.0062 0.0544 0.0902
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0045 0.0332 0.0332
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0687
Entamoeba histolytica cysteine proteinase, putative 0.0118 0.1228 0.9925
Echinococcus granulosus cathepsin l1 0.0118 0.1228 0.1228
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Echinococcus multilocularis cysteine protease 0.0118 0.1228 0.1228
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Loa Loa (eye worm) hypothetical protein 0.0158 0.1716 0.2869
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0118 0.1228 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0332 0.0546
Plasmodium falciparum serine repeat antigen 7 0.0034 0.0191 0.1556
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0482 0.0482
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0404 0.0666
Echinococcus granulosus cathepsin L cysteine proteinase 0.0118 0.1228 0.1228
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0177 0.0286
Toxoplasma gondii cathepsin CPC2 0.0034 0.0191 0.0966
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0244 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0118 0.1228 0.2049
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0034 0.0191 0.1556
Brugia malayi Bromodomain containing protein 0.0041 0.0275 0.0296
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0191 0.1556
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0244 0.0244
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0183 0.0924
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0034 0.0191 0.1556
Plasmodium falciparum serine repeat antigen 4 0.0034 0.0191 0.1556
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Schistosoma mansoni zinc finger protein 0.0021 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0198 0.0012
Onchocerca volvulus 0.0058 0.0492 0.1621
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3281 0.3281
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0034 0.0191 0.0962
Onchocerca volvulus 0.0118 0.1228 0.5405
Echinococcus multilocularis protein dispatched 1 0.0058 0.0492 0.0492
Schistosoma mansoni hypothetical protein 0.0079 0.075 0.075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni protein phosphatase 2C 0.0045 0.0332 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Echinococcus granulosus cathepsin b 0.0504 0.5964 0.5964
Schistosoma mansoni phd/f-box containing protein 0.0045 0.0332 0.0332
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0238 0.2692 0.2692
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0045 0.0332 0.0244
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.1543 0.1543
Toxoplasma gondii cathepsin CPC1 0.0034 0.0191 0.0966
Echinococcus multilocularis cathepsin L cysteine protease 0.0118 0.1228 0.1228
Toxoplasma gondii preprocathepsin c precursor, putative 0.0034 0.0191 0.0966
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0371 0.0371
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0613 0.1018
Echinococcus granulosus tumor protein p63 0.0357 0.4162 0.4162
Schistosoma mansoni jumonji/arid domain-containing protein 0.0171 0.1881 0.1881
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0504 0.5964 0.5964
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0211 0.5
Echinococcus granulosus muscleblind protein 0.0158 0.1716 0.1716
Entamoeba histolytica cysteine protease, putative 0.0118 0.1228 0.9925
Onchocerca volvulus 0.0118 0.1228 0.5405
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0397 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.042 0.042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0034 0.0191 0.1556
Brugia malayi jmjC domain containing protein 0.0238 0.2692 0.4419
Loa Loa (eye worm) hypothetical protein 0.0118 0.1228 0.2049
Schistosoma mansoni bromodomain containing protein 0.0067 0.0599 0.0599
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Trypanosoma cruzi cysteine peptidase, putative 0.0118 0.1228 0.1795
Plasmodium vivax vivapain-1 0.0068 0.0611 0.4979
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0191 0.212 1
Schistosoma mansoni cathepsin F (C01 family) 0.0118 0.1228 0.1228
Brugia malayi Cathepsin L-like precursor 0.0084 0.0807 0.1205
Loa Loa (eye worm) hypothetical protein 0.0051 0.0404 0.0666
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.0807 0.6291
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0357 0.0357
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus multilocularis lysine specific demethylase 6a 0.0045 0.0332 0.0332
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0191 0.0309
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0611 0.087
Chlamydia trachomatis pyruvate kinase 0.0035 0.0211 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0695 0.1156
Loa Loa (eye worm) hypothetical protein 0.0057 0.0482 0.0798
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0179 0.1977 0.3093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1259 0.1259
Schistosoma mansoni jumonji domain containing protein 0.0045 0.0332 0.0332
Plasmodium falciparum serine repeat antigen 3 0.0034 0.0191 0.1556
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Echinococcus granulosus lysine specific demethylase 5A 0.0171 0.1881 0.1881
Echinococcus granulosus phd:f box containing protein 0.0045 0.0332 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0611 0.2268
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0191 0.0153
Brugia malayi hypothetical protein 0.0079 0.075 0.1106
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0191 0.0153
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0118 0.1228 0.5805
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0211 0.1066
Schistosoma mansoni pyruvate kinase 0.0035 0.0211 0.0211
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0397 0.0397
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0504 0.5964 1
Plasmodium falciparum phd finger protein, putative 0.0033 0.0183 0.1487
Entamoeba histolytica hypothetical protein 0.0079 0.075 0.5792
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0034 0.0191 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0397 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni pyruvate kinase 0.0035 0.0211 0.0211
Plasmodium falciparum serine repeat antigen 5 0.0034 0.0191 0.1556
Entamoeba histolytica hypothetical protein 0.0034 0.0191 0.0962
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0211 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Echinococcus multilocularis cathepsin L 0.0034 0.0191 0.0191
Loa Loa (eye worm) jmjC domain-containing protein 0.0171 0.1881 0.3146
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0034 0.0191 0.0966
Brugia malayi cathepsin L-like cysteine proteinase 0.0034 0.0191 0.0153
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0211 0.0342
Loa Loa (eye worm) hypothetical protein 0.0032 0.017 0.0274
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Schistosoma mansoni hypothetical protein 0.0307 0.354 0.354
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0397 0.0397
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0183 0.0295
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0068 0.0611 0.0611
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0357 0.0357
Onchocerca volvulus 0.005 0.0397 0.113
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Brugia malayi mbt repeat family protein 0.005 0.0397 0.0504
Giardia lamblia Cysteine protease 0.0034 0.0191 0.0966
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0611 0.2353
Loa Loa (eye worm) hypothetical protein 0.0043 0.0306 0.0503
Brugia malayi hypothetical protein 0.0286 0.3281 0.5423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0611 0.2353
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni lamin 0.0033 0.0177 0.0177
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0191 0.007
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Giardia lamblia Cathepsin B precursor 0.0179 0.1977 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0371 0.0371
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0611 0.0728
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0068 0.0611 0.0728
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0034 0.0191 0.0191
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0492 0.0667
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0034 0.0191 0.1556
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.007 0.007
Loa Loa (eye worm) cysteine protease 0.0118 0.1228 0.2049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Plasmodium falciparum serine repeat antigen 6 0.0034 0.0191 0.1556
Plasmodium vivax unspecified product 0.0034 0.0198 0.1613
Brugia malayi cathepsin Z-like cysteine proteinase 0.0034 0.0191 0.0153
Loa Loa (eye worm) hypothetical protein 0.0033 0.0183 0.0295
Echinococcus multilocularis geminin 0.0179 0.1977 0.1977
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Plasmodium falciparum cysteine proteinase falcipain 3 0.0118 0.1228 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0084 0.0807 0.1068
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0034 0.0191 0.0191
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1236 0.1236
Plasmodium vivax unspecified product 0.0068 0.0611 0.4979
Echinococcus multilocularis lysine specific demethylase 5A 0.0169 0.1856 0.1856
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0482 0.065
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Plasmodium vivax vivapain-2 0.0118 0.1228 1
Brugia malayi Cathepsin L-like precursor 0.0118 0.1228 0.1921
Plasmodium falciparum serine repeat antigen 9 0.0034 0.0191 0.1556
Schistosoma mansoni phosphatidylserine receptor 0.0045 0.0332 0.0332
Onchocerca volvulus 0.0118 0.1228 0.5405
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Plasmodium falciparum serine repeat antigen 2 0.0034 0.0191 0.1556
Entamoeba histolytica cysteine protease, putative 0.0068 0.0611 0.4596
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0034 0.0191 0.1556
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1862 0.1862
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0118 0.1228 0.5805
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0404 0.0404
Toxoplasma gondii cathepsin CPL 0.0118 0.1228 0.6211
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0199 0.2217 0.2217
Onchocerca volvulus Cathepsin F homolog 0.0118 0.1228 0.5405
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0045 0.0332 0.168
Schistosoma mansoni hypothetical protein 0.0049 0.0381 0.0381
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0177 0.0286
Echinococcus granulosus JmjC domain containing protein 4 0.0045 0.0332 0.0332
Echinococcus granulosus cathepsin L 0.0034 0.0191 0.0191
Trypanosoma cruzi cysteine proteinase, putative 0.0068 0.0611 0.0728
Onchocerca volvulus Cathepsin L homolog 0.0118 0.1228 0.5405
Echinococcus granulosus peregrin 0.0035 0.0213 0.0213
Loa Loa (eye worm) MBCTL1 0.0057 0.0482 0.0798
Entamoeba histolytica cysteine protease, putative 0.0034 0.0191 0.0962
Entamoeba histolytica cysteine proteinase 2 0.0068 0.0611 0.4596
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0034 0.0191 0.1556
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0179 0.1977 1
Echinococcus multilocularis expressed conserved protein 0.0112 0.1148 0.1148
Echinococcus multilocularis JmjC domain containing protein 4 0.0045 0.0332 0.0332
Brugia malayi cathepsin F-like cysteine proteinase 0.0034 0.0198 0.0165
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0404 0.0404
Echinococcus multilocularis muscleblind protein 0.0158 0.1716 0.1716
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Loa Loa (eye worm) ctsf protein 0.0118 0.1228 0.2049
Echinococcus multilocularis cathepsin L 0.0068 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0091 0.0895 0.1491
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0118 0.1228 0.2049
Leishmania major cathepsin L-like protease 0.0118 0.1228 0.5758
Loa Loa (eye worm) hypothetical protein 0.0034 0.0198 0.0321
Trypanosoma cruzi cysteine protease, putative 0.0068 0.0611 0.0728
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1236 0.1936
Giardia lamblia Cathepsin L precursor 0.0034 0.0191 0.0966
Entamoeba histolytica cysteine proteinase, putative 0.0068 0.0611 0.4596
Schistosoma mansoni cathepsin F (C01 family) 0.0118 0.1228 0.1228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0118 0.1228 0.5758
Schistosoma mansoni patched 1 0.0051 0.0404 0.0404
Brugia malayi Cathepsin L-like cysteine proteinase 0.0084 0.0807 0.1205
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0183 0.0183
Giardia lamblia Cathepsin B precursor 0.0034 0.0191 0.0966
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0504 0.5964 0.5964
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0179 0.1977 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0211 0.5
Loa Loa (eye worm) hypothetical protein 0.0084 0.0807 0.1343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0179 0.1977 0.1977
Plasmodium vivax vivapain-3 0.0068 0.0611 0.4979
Brugia malayi jmjC domain containing protein 0.0045 0.0332 0.0394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0371 0.0371
Brugia malayi CHE-14 protein 0.0051 0.0404 0.0516
Giardia lamblia Cathepsin L-like protease 0.0034 0.0191 0.0966
Plasmodium vivax unspecified product 0.0034 0.0191 0.1556
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0211 0.0172
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0332 0.0546
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0552 0.0552
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0211 0.0187
Loa Loa (eye worm) hypothetical protein 0.0034 0.0191 0.0309
Onchocerca volvulus 0.0118 0.1228 0.5405
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.1411 0.1411

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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