Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Onchocerca volvulus | 0.0035 | 0.4403 | 0.5 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.5396 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.5381 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 0.6015 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 0.6015 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.0453 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.7362 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.7362 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.7362 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.7362 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.7362 | 0.7362 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.