Detailed information for compound 188866

Basic information

Technical information
  • TDR Targets ID: 188866
  • Name: 5,7-diamino-2-(4-aminophenyl)-6-hydroxychrome n-4-one
  • MW: 283.282 | Formula: C15H13N3O3
  • H donors: 4 H acceptors: 2 LogP: 1.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ccc(cc1)c1cc(=O)c2c(o1)cc(c(c2N)O)N
  • InChi: 1S/C15H13N3O3/c16-8-3-1-7(2-4-8)11-6-10(19)13-12(21-11)5-9(17)15(20)14(13)18/h1-6,20H,16-18H2
  • InChiKey: ALORFJGZFRLFCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5,7-diamino-2-(4-aminophenyl)-6-hydroxy-chromen-4-one
  • 5,7-diamino-2-(4-aminophenyl)-6-hydroxy-1-benzopyran-4-one
  • 2-(4-aminophenyl)-5,7-bis(azanyl)-6-hydroxy-chromen-4-one
  • 5,7-diamino-2-(4-aminophenyl)-6-hydroxy-chromone
  • 5,7-diamino-2-(4-aminophenyl)-6-hydroxy-4-chromenone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Chlamydia trachomatis glutamine binding protein 0.0041 0.1395 1
Plasmodium falciparum DNA topoisomerase 2 0.0063 0.2817 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0057 0.241 0.7752
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0053 0.2197 0.7064
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.1949 0.6265
Trypanosoma brucei metacaspase MCA2 0.0049 0.1949 0.6265
Echinococcus granulosus nmda type glutamate receptor 0.0057 0.2417 0.3365
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.3132 0.9881
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Trypanosoma brucei metacaspase 5, putative 0.0049 0.1949 0.6265
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.3132 0.4364
Echinococcus multilocularis glutamate receptor 2 0.0024 0.0321 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0919 0.2943
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0034 0.0963 0.3076
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.3169 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0063 0.2817 0.3923
Leishmania major mitochondrial DNA topoisomerase II 0.0049 0.1953 0.6155
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0053 0.2197 0.7064
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Plasmodium vivax metacaspase 1, putative 0.0049 0.1949 0.6801
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1435 0.4606
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0068 0.3169 1
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.3107 0.9797
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0963 0.1335
Echinococcus granulosus caspase 3 0.0081 0.3994 0.5567
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.1672 0.537
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0063 0.2817 0.5735
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0049 0.1949 0.2712
Trypanosoma cruzi metacaspase, putative 0.0049 0.1949 0.6265
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0024 0.0321 0.0437
Schistosoma mansoni glutamate receptor NMDA 0.0024 0.0321 0.0437
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0057 0.2417 0.3365
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0321 0.0437
Plasmodium falciparum metacaspase-like protein 0.0049 0.1949 0.6801
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0021 0.0104 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Loa Loa (eye worm) hypothetical protein 0.0053 0.2197 0.4469
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.1198 0.3842
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0044 0.1579 0.1573
Entamoeba histolytica DNA topoisomerase II, putative 0.0063 0.2817 1
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3132 0.4364
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Loa Loa (eye worm) hypothetical protein 0.0028 0.0561 0.1131
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.1672 0.5265
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.1953 0.6278
Trichomonas vaginalis FMN-dependent NADH-azoreductase, putative 0.0044 0.1579 0.1573
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0068 0.3169 0.4415
Trypanosoma brucei DNA topoisomerase ii 0.0049 0.1953 0.6278
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.1198 0.2431
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0024 0.0321 0.0437
Echinococcus granulosus apoptotic protease activating factor 1 0.0046 0.1731 0.2407
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.1198 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Loa Loa (eye worm) hypothetical protein 0.0042 0.1487 0.302
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.3107 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0049 0.1949 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trypanosoma brucei Metacaspase-4 0.0049 0.1949 0.6265
Brugia malayi Cell death protein 3 precursor 0.0095 0.4906 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0063 0.2817 0.3923
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0068 0.3169 0.6454
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0321 0.0437
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Plasmodium vivax DNA topoisomerase II, putative 0.0063 0.2817 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.3107 1
Giardia lamblia NADPH oxidoreductase, putative 0.0175 1 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0321 0.0437
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0053 0.2197 0.7792
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.1672 0.5115
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.1198 0.2431
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.3169 0.4415
Echinococcus granulosus glutamate receptor 2 0.0024 0.0321 0.0437
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.1198 0.4239
Trypanosoma brucei unspecified product 0.0026 0.0446 0.1415
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trypanosoma brucei metacaspase MCA3 0.0049 0.1949 0.6265
Brugia malayi hypothetical protein 0.0046 0.1731 0.3519
Trypanosoma cruzi metacaspase 5, putative 0.0049 0.1949 0.6265
Echinococcus multilocularis caspase 8 0.0049 0.1949 0.2712
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.1949 0.6223
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0041 0.1395 1
Leishmania major DNA polymerase eta, putative 0.0038 0.1198 0.3767
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.3132 0.4364
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.3132 0.4364
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0019 0.0007 0.0023
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0053 0.2197 0.7064
Echinococcus granulosus protein arginine methyltransferase 0.0034 0.0963 0.1335
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.3107 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1731 0.3519
Entamoeba histolytica hypothetical protein 0.0044 0.1579 0.5594
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.3107 0.9797
Echinococcus multilocularis protein arginine methyltransferase 0.0034 0.0963 0.1335
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0175 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.3132 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0068 0.3169 1
Echinococcus granulosus caspase 8 0.0049 0.1949 0.2712
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0034 0.0963 0.1335
Echinococcus multilocularis dna polymerase kappa 0.0067 0.3107 0.4328
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Brugia malayi hypothetical protein 0.0053 0.2197 0.4469
Onchocerca volvulus 0.0046 0.1731 0.0081
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Loa Loa (eye worm) hypothetical protein 0.0042 0.1487 0.302
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.1198 0.3842
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.1198 0.3569
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0175 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Echinococcus multilocularis caspase 0.0131 0.7169 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.3107 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.241 0.7752
Echinococcus granulosus caspase 2 0.0095 0.4906 0.6841
Toxoplasma gondii bicoid-interacting protein BIN3 0.0019 0.0007 0.0023
Echinococcus granulosus caspase 0.0131 0.7169 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Loa Loa (eye worm) hypothetical protein 0.0028 0.0561 0.1131
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.1949 0.6223
Echinococcus multilocularis dna polymerase eta 0.0038 0.1198 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.1198 0.1663
Leishmania major arginine N-methyltransferase-like protein 0.0034 0.0963 0.3024
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Loa Loa (eye worm) hypothetical protein 0.0038 0.1198 0.2431
Echinococcus multilocularis nmda type glutamate receptor 0.0057 0.2417 0.3365
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.1198 0.2431
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0041 0.1395 1
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Leishmania major DNA topoisomerase ii 0.0057 0.241 0.76
Trypanosoma cruzi metacaspase, putative 0.0049 0.1949 0.6265
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0049 0.1953 0.6278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.1198 0.1663
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0919 0.2943
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trypanosoma brucei unspecified product 0.006 0.2633 0.8472
Plasmodium vivax hypothetical protein, conserved 0.0049 0.1949 0.6801
Loa Loa (eye worm) TOPoisomerase family member 0.0063 0.2817 0.5735
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.3107 0.3102
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3132 0.9881
Plasmodium falciparum metacaspase 1 0.0049 0.1949 0.6801
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Schistosoma mansoni caspase-3 (C14 family) 0.0131 0.7169 1
Leishmania major metacaspase, putative 0.0049 0.1949 0.6142
Trypanosoma cruzi metacaspase, putative 0.0049 0.1949 0.6265
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0919 0.2943
Echinococcus granulosus protein arginine N methyltransferase 8 0.0034 0.0963 0.1335
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0963 0.1335
Brugia malayi Probable DNA topoisomerase II 0.0063 0.2817 0.5735
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0131 0.7169 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0041 0.1395 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0034 0.0963 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0963 0.0957
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0068 0.3169 0.4415
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0963 0.0957
Entamoeba histolytica iron-sulfur flavoprotein, putative 0.0044 0.1579 0.5594
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.2633 0.8472
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0321 0.0437
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3132 0.9881
Loa Loa (eye worm) hypothetical protein 0.0095 0.4906 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0041 0.1395 0.421
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0019 0.0007 0.0023
Onchocerca volvulus Cell death protein 3 homolog 0.0095 0.4906 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.1198 0.1663
Leishmania major DNA polymerase kappa, putative 0.0045 0.1672 0.5265
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0068 0.3169 1
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.3107 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.1435 0.4606
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.3132 0.9885
Trypanosoma cruzi metacaspase, putative 0.0049 0.1949 0.6265
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.3107 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0041 0.1395 0.421
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0034 0.0963 0.0957
Loa Loa (eye worm) hypothetical protein 0.0041 0.1435 0.2914
Loa Loa (eye worm) hypothetical protein 0.0049 0.1949 0.3964
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0034 0.0968 0.6694
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.0095 0.4906 0.6841
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Brugia malayi polk-prov protein 0.0041 0.1435 0.2914
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0131 0.7195 0.7193
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.3107 0.3102
Schistosoma mansoni caspase-7 (C14 family) 0.0131 0.7169 1
Entamoeba histolytica hypothetical protein 0.0053 0.2197 0.7792
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0034 0.0963 0.3167
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0044 0.1579 0.1573
Toxoplasma gondii DNA topoisomerase 2, putative 0.0063 0.2817 0.8993
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Schistosoma mansoni hypothetical protein 0.0046 0.1731 0.2407
Schistosoma mansoni DNA polymerase eta 0.0038 0.1198 0.1663
Echinococcus multilocularis caspase 3 0.0081 0.3994 0.5567
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0024 0.0321 0.0437
Echinococcus granulosus dna polymerase eta 0.0038 0.1198 0.1663
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0034 0.0963 0.3167
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0131 0.7169 1
Echinococcus granulosus dna polymerase kappa 0.0067 0.3107 0.4328
Trichomonas vaginalis NAD(P)H dehydrogenase, putative 0.0175 1 1
Schistosoma mansoni DNA topoisomerase II 0.0063 0.2817 0.3923
Echinococcus multilocularis caspase 2 0.0095 0.4906 0.6841
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.2614 0.5322
Trypanosoma brucei unspecified product 0.0026 0.0446 0.1415
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.3132 0.9881
Entamoeba histolytica modulator of drug activity B homolog, putative 0.0044 0.1579 0.5594
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.1949 0.1943
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0024 0.0321 0.0437
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0057 0.241 0.7752
Trypanosoma brucei metacaspase 0.0049 0.1949 0.6265
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.1579 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0049 0.1949 0.6223
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0104 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0175 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.3107 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0063 0.2817 0.5735
Trichomonas vaginalis DNA topoisomerase II, putative 0.0063 0.2817 0.2812
Giardia lamblia NADPH oxidoreductase, putative 0.0175 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0057 0.241 0.7752
Giardia lamblia DNA topoisomerase II 0.006 0.2638 0.1161
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0049 0.1949 0.1943
Trichomonas vaginalis modulator of drug activity B, putative 0.0044 0.1579 0.1573
Echinococcus multilocularis apoptotic protease activating factor 1 0.0046 0.1731 0.2407

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 18 uM In vitro inhibition of protein-tyrosine activity of p56lck enzyme in presence of 50 uM ATP ChEMBL. 7932563
IC50 (binding) = 18 uM In vitro inhibition of protein-tyrosine activity of p56lck enzyme in presence of 50 uM ATP ChEMBL. 7932563
IC50 (binding) > 50 uM Inhibition of in vitro protein-tyrosine kinase activity of p60v-src enzyme in presence of 5 uM ATP. ChEMBL. 7932563
IC50 (binding) > 50 uM Inhibition of in vitro protein-tyrosine kinase activity of p60v-src enzyme in presence of 5 uM ATP. ChEMBL. 7932563
IC50 (binding) > 100 uM Inhibition of in vitro activity of EGFr enzyme from A431 cells in presence of 5 uM ATP ChEMBL. 7932563
IC50 (binding) > 100 uM Inhibition of in vitro activity of EGFr enzyme from A431 cells in presence of 5 uM ATP ChEMBL. 7932563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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