Detailed information for compound 1888714

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.708 | Formula: C13H14ClNO3
  • H donors: 1 H acceptors: 1 LogP: 3.3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC1OC(=C(/C/1=N\c1ccccc1C)Cl)O
  • InChi: 1S/C13H14ClNO3/c1-3-17-13-11(10(14)12(16)18-13)15-9-7-5-4-6-8(9)2/h4-7,13,16H,3H2,1-2H3/b15-11+
  • InChiKey: IUBJIEILKOGSHV-RVDMUPIBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0522 0.0519
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0407 0.1838
Brugia malayi ecdysone receptor 0.0011 0.0003 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0298 0.1347
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0298 0.0295
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0003 0.0013
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0407 0.1827
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0298 0.0295
Brugia malayi intermediate filament protein 0.0027 0.0407 0.1838
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0298 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0887 0.0884
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0298 0.0295
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0298 0.0295
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1254 0.5
Echinococcus granulosus lamin dm0 0.0027 0.0407 0.0404
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0519
Trypanosoma brucei protein kinase, putative 0.0062 0.1254 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0298 0.1347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0298 0.1336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0887 0.0884
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0298 0.0295
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0143
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1254 0.1252
Schistosoma mansoni lamin 0.0027 0.0407 0.0404
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0522 0.2348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0298 0.1347
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1254 0.1252
Schistosoma mansoni cpg binding protein 0.0037 0.0642 0.0639
Echinococcus granulosus intermediate filament protein 0.0027 0.0407 0.0404
Echinococcus multilocularis cpg binding protein 0.0037 0.0642 0.0639
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1254 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0394 0.1772
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0522 0.0519
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0519
Echinococcus multilocularis lamin 0.0027 0.0407 0.0404
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0013 0.0011
Schistosoma mansoni hypothetical protein 0.0152 0.3483 0.3481
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1254 1
Echinococcus granulosus geminin 0.0346 0.8265 0.8264
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1254 0.1252
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0298 0.1347
Brugia malayi nuclear receptor NHR-88 0.0023 0.0298 0.1347
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0298 0.1347
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1329 0.1326
Echinococcus granulosus lamin 0.0027 0.0407 0.0404
Echinococcus multilocularis thyroid hormone receptor alpha 0.0175 0.4042 0.404
Brugia malayi ecdysteroid receptor 0.0023 0.0298 0.1347
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0209
Brugia malayi RNA binding protein 0.0065 0.1329 0.6005
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1329 0.1326
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0298 0.0295
Brugia malayi nuclear hormone receptor 0.0011 0.0003 0.0013
Brugia malayi nuclear receptor RXR 0.0011 0.0003 0.0013
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1254 0.1252
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0298 0.5002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0298 0.1347
Brugia malayi hypothetical protein 0.0011 0.0003 0.0013
Brugia malayi MAP kinase sur-1 0.0062 0.1254 0.567
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0298 0.1347
Loa Loa (eye worm) hypothetical protein 0.01 0.2213 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0143
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0298 0.0295
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0351 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1329 0.6
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0522 0.0519
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Echinococcus granulosus GPCR family 2 0.0032 0.0522 0.0519
Schistosoma mansoni thyroid hormone receptor 0.0175 0.4042 0.404
Loa Loa (eye worm) hypothetical protein 0.0013 0.0061 0.0264
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0593 0.2672
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0003 0.0001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1254 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0887 0.4008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1357 1
Schistosoma mansoni thyroid hormone receptor 0.0175 0.4042 0.404
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1254 0.5664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0298 0.0295
Echinococcus multilocularis musashi 0.0027 0.0407 0.0404
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0003 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1254 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0298 0.0295
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0003 0.0013
Brugia malayi nuclear receptor NHR-88 0.0011 0.0003 0.0013
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0887 0.0884
Schistosoma mansoni hypothetical protein 0.0417 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Loa Loa (eye worm) hypothetical protein 0.0013 0.0049 0.0209
Schistosoma mansoni lamin 0.0027 0.0407 0.0404
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2213 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0034 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0298 0.1347
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0011
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1254 0.5
Schistosoma mansoni cpg binding protein 0.0037 0.0642 0.0639
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0298 0.0295
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0522 0.2358
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0407 0.1827
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1551 0.1548
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0298 0.0295
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0003 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.143 0.6458
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0298 0.1347
Loa Loa (eye worm) RNA binding protein 0.0065 0.1329 0.6
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1254 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0061 0.0058
Onchocerca volvulus 0.0023 0.0298 0.5002
Brugia malayi hypothetical protein 0.0025 0.0351 0.1585
Brugia malayi conserved hypotetical protein 0.0011 0.0003 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0298 0.1336
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0298 0.1347
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0298 0.1336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0351 0.5
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1254 0.1252
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0034 0.0032
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1254 1
Schistosoma mansoni hypothetical protein 0.0069 0.143 0.1428
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0298 0.0295
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0298 0.0295
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0013 0.0011
Brugia malayi TAR-binding protein 0.0065 0.1329 0.6005
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0061 0.0058
Schistosoma mansoni intermediate filament proteins 0.0027 0.0407 0.0404
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0097 0.0437
Schistosoma mansoni cpg binding protein 0.0035 0.0593 0.0591
Onchocerca volvulus 0.0027 0.0407 0.6839
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1329 0.6
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0298 0.0295
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0298 0.0295
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0298 0.0295
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0298 0.0295
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0298 0.0295
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0034 0.0032
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0298 0.1336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0887 0.0884
Onchocerca volvulus 0.0035 0.0593 1
Brugia malayi tailless protein 0.0011 0.0003 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0887 0.0884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0298 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0298 0.1336
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0298 0.5002
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0003 0.0013
Echinococcus multilocularis GPCR, family 2 0.0032 0.0522 0.0519
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0298 0.5002
Brugia malayi nuclear receptor NHR-67 0.0011 0.0003 0.0013
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0003 0.0013
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1254 1
Schistosoma mansoni hypothetical protein 0.0346 0.8265 0.8264
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.143 0.6463
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0298 0.1347
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.3483 0.3481
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1329 0.6005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0298 0.1336
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1254 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0034 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0298 0.1347
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0298 0.0295
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1329 0.1326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0887 0.0884
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0522 0.2358
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0522 0.0519
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0298 0.0295
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0887 0.4001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2213 1
Brugia malayi hypothetical protein 0.0016 0.0134 0.0606
Schistosoma mansoni coup transcription factor 0.0023 0.0298 0.0295
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0097 0.0425
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0298 0.0295
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1254 0.8979
Brugia malayi hypothetical protein 0.0012 0.0034 0.0156
Brugia malayi CXXC zinc finger family protein 0.0035 0.0593 0.2681
Loa Loa (eye worm) hypothetical protein 0.0023 0.0298 0.1336
Echinococcus multilocularis geminin 0.0346 0.8265 0.8264
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0298 0.0295
Echinococcus granulosus cpg binding protein 0.0037 0.0642 0.0639
Brugia malayi nuclear hormone receptor 0.0023 0.0298 0.1347
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0298 0.0295
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0298 0.0295
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0351 0.5
Onchocerca volvulus 0.0027 0.0407 0.6839
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0887 0.0884
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1329 0.1326
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.3483 0.3481
Loa Loa (eye worm) hypothetical protein 0.0025 0.0351 0.1575
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0298 0.1347
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0519
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0143
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0034 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1329 0.1326
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0298 0.1347
Echinococcus granulosus tar DNA binding protein 0.0065 0.1329 0.1326
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0003 0.0013
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1254 0.5
Brugia malayi hypothetical protein 0.0011 0.0003 0.0013
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1254 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.0522 0.0519
Loa Loa (eye worm) hypothetical protein 0.0032 0.0522 0.2348
Schistosoma mansoni hypothetical protein 0.0346 0.8265 0.8264
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0034 0.0156
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0298 0.1347
Brugia malayi hypothetical protein 0.0012 0.0034 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0298 0.1347
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2213 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0298 0.0295
Loa Loa (eye worm) hypothetical protein 0.0027 0.0407 0.1827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0298 0.1336
Echinococcus multilocularis lamin dm0 0.0027 0.0407 0.0404
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1329 0.1326
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0034 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0298 0.0295
Brugia malayi steroid hormone receptor 0.0023 0.0298 0.1347
Brugia malayi nuclear receptor RXR 0.0012 0.0034 0.0156

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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