TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 367.417 | Formula: C21H22FN3O2
H donors: 2 H acceptors: 2 LogP: 3.88 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CNC(=O)c1cccc(c1)F)N/N=C(\c1ccc2c(c1)CCCC2)/C
InChi: 1S/C21H22FN3O2/c1-14(16-10-9-15-5-2-3-6-17(15)11-16)24-25-20(26)13-23-21(27)18-7-4-8-19(22)12-18/h4,7-12H,2-3,5-6,13H2,1H3,(H,23,27)(H,25,26)/b24-14-
InChiKey: OSZKYDKJQXRRBX-OYKKKHCWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Tubulin beta 2C chain	0.0051	0.6692	1
Trichomonas vaginalis	tubulin, putative	0.0011	0.0907	0.0776
Schistosoma mansoni	alpha tubulin	0.002	0.216	0.216
Brugia malayi	Tubulin alpha chain	0.002	0.216	0.2648
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Echinococcus multilocularis	Tubulin alpha 1 chain	0.002	0.216	0.2648
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.4331	0.617
Echinococcus multilocularis	hypothetical protein	0.002	0.216	0.2648
Trypanosoma brucei	tubulin gamma chain	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Leishmania major	beta tubulin	0.0051	0.6692	1
Echinococcus multilocularis	beta tubulin	0.0051	0.6692	1
Echinococcus granulosus	tubulin beta 1 chain	0.0051	0.6692	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0011	0.0907	0.0616
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0528	0.0171
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Echinococcus granulosus	tubulin alpha chain	0.002	0.216	0.2648
Loa Loa (eye worm)	tubulin alpha 2	0.0011	0.0907	0.0616
Trypanosoma brucei	beta tubulin	0.0051	0.6692	1
Loa Loa (eye worm)	alpha-tubulin	0.002	0.216	0.2648
Trypanosoma brucei	alpha tubulin, putative	0.0011	0.0907	0.0616
Trypanosoma cruzi	epsilon tubulin, putative	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0009	0.0528	0.0171
Treponema pallidum	cell division protein FtsZ	0.0009	0.0528	0.5
Entamoeba histolytica	tubulin family protein	0.0051	0.6692	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin alpha chain, putative	0.0051	0.6692	1
Echinococcus multilocularis	tubulin alpha	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Trypanosoma brucei	beta tubulin	0.0051	0.6692	1
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Echinococcus granulosus	tubulin subunit beta	0.0051	0.6692	1
Trypanosoma brucei	alpha tubulin	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin, putative	0.0011	0.0907	0.0776
Echinococcus multilocularis	tubulin alpha 3 chain	0.002	0.216	0.2648
Schistosoma mansoni	cpg binding protein	0.0037	0.4619	0.4619
Echinococcus granulosus	tubulin beta 4A class IVa	0.0051	0.6692	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0907	0.0616
Echinococcus granulosus	alpha tubulin	0.002	0.216	0.2648
Loa Loa (eye worm)	beta-tubulin	0.0051	0.6692	1
Trichomonas vaginalis	tubulin, putative	0.0051	0.6692	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0051	0.6692	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0011	0.0907	0.0776
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Echinococcus multilocularis	Tubulin beta 2C chain	0.0051	0.6692	1
Trypanosoma cruzi	alpha tubulin, putative	0.002	0.216	0.2648
Leishmania major	gamma-tubulin	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Plasmodium vivax	tubulin beta chain, putative	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit beta	0.0009	0.0528	0.0528
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0907	0.0776
Echinococcus granulosus	tubulin alpha chain	0.002	0.216	0.2648
Brugia malayi	beta-tubulin, identical	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit alpha	0.0009	0.0528	0.0528
Leishmania major	beta tubulin	0.0051	0.6692	1
Loa Loa (eye worm)	tubulin alpha chain	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Schistosoma mansoni	cpg binding protein	0.0037	0.4619	0.4619
Brugia malayi	Tubulin beta chain	0.0011	0.0907	0.0616
Echinococcus granulosus	Tubulin beta 2C chain	0.0051	0.6692	1
Entamoeba histolytica	tubulin family protein	0.0051	0.6692	1
Echinococcus granulosus	tubulin alpha 1C chain	0.002	0.216	0.2648
Brugia malayi	Tubulin gamma chain	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.002	0.216	0.2648
Echinococcus multilocularis	peroxisome assembly protein 26	0.002	0.216	0.2648
Plasmodium vivax	tubulin alpha chain, putative	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Echinococcus granulosus	cpg binding protein	0.0037	0.4619	0.6638
Echinococcus multilocularis	tubulin alpha 1C chain	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin gamma chain, putative	0.0009	0.0528	0.0171
Trichomonas vaginalis	tubulin gamma chain, putative	0.002	0.216	0.2774
Echinococcus granulosus	tubulin alpha	0.002	0.216	0.2648
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0839	0.0506
Echinococcus multilocularis	Tubulin alpha 1 chain	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Plasmodium falciparum	tubulin gamma chain	0.002	0.216	0.2648
Plasmodium falciparum	alpha tubulin 1	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0907	0.0776
Echinococcus multilocularis	tubulin beta 1 chain	0.0051	0.6692	1
Giardia lamblia	Alpha-tubulin	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin subunit beta	0.0051	0.6692	1
Trypanosoma cruzi	tubulin gamma chain	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin alpha 1C chain	0.002	0.216	0.2648
Brugia malayi	Tubulin alpha-2 chain	0.002	0.216	0.2648
Toxoplasma gondii	beta-1 tubulin, putative	0.0051	0.6692	0.7403
Schistosoma mansoni	tubulin subunit alpha	0.002	0.216	0.216
Trypanosoma brucei	epsilon tubulin	0.002	0.216	0.2648
Schistosoma mansoni	alpha tubulin	0.002	0.216	0.216
Echinococcus granulosus	peroxisome assembly protein 26	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0531	0.0531
Echinococcus granulosus	Tubulin beta 2C chain	0.0051	0.6692	1
Echinococcus granulosus	tubulin gamma 1 chain	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin gamma 1 chain	0.002	0.216	0.2648
Echinococcus multilocularis	cpg binding protein	0.0037	0.4619	0.6638
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0009	0.0528	0.0171
Echinococcus granulosus	Tubulin beta 2C chain	0.0051	0.6692	1
Trypanosoma brucei	beta tubulin	0.0051	0.6692	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0051	0.6692	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0009	0.0528	0.0171
Trypanosoma brucei	beta tubulin	0.0051	0.6692	1
Trypanosoma cruzi	beta tubulin, putative	0.0051	0.6692	1
Giardia lamblia	Alpha-tubulin	0.002	0.216	0.2648
Echinococcus granulosus	tubulin alpha chain	0.002	0.216	0.2648
Plasmodium falciparum	tubulin epsilon chain, putative	0.002	0.216	0.2648
Echinococcus granulosus	beta tubulin	0.0051	0.6692	1
Echinococcus granulosus	tubulin alpha chain	0.002	0.216	0.2648
Echinococcus granulosus	tubulin alpha 3 chain	0.002	0.216	0.2648
Trypanosoma brucei	alpha tubulin	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Leishmania major	beta tubulin	0.0051	0.6692	1
Trypanosoma cruzi	epsilon tubulin, putative	0.002	0.216	0.2648
Echinococcus granulosus	tubulin epsilon chain	0.002	0.216	0.2648
Echinococcus granulosus	tubulin alpha 3 chain	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0051	0.6692	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.002	0.216	0.2648
Plasmodium vivax	tubulin alpha chain, putative	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.002	0.216	0.2648
Echinococcus multilocularis	Tubulin alpha 1 chain	0.002	0.216	0.2648
Plasmodium falciparum	tubulin beta chain	0.0051	0.6692	1
Schistosoma mansoni	cpg binding protein	0.0035	0.4331	0.4331
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0531	0.0005
Leishmania major	beta tubulin	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Loa Loa (eye worm)	tubulin beta-1 chain	0.0051	0.6692	1
Leishmania major	beta tubulin	0.0051	0.6692	1
Leishmania major	beta tubulin	0.0051	0.6692	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0051	0.6692	1
Loa Loa (eye worm)	tubulin alpha 2	0.0011	0.0907	0.0616
Toxoplasma gondii	alpha-tubulin I, putative	0.002	0.216	0.1961
Echinococcus multilocularis	tubulin epsilon chain	0.002	0.216	0.2648
Loa Loa (eye worm)	alpha-tubulin	0.002	0.216	0.2648
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0009	0.0531	0.0005
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0011	0.0907	0.0776
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0051	0.6692	1
Brugia malayi	tubulin alpha-2 chain	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin epsilon chain, putative	0.002	0.216	0.2774
Plasmodium vivax	tubulin gamma chain, putative	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Leishmania major	beta tubulin	0.0051	0.6692	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.216	0.2648
Onchocerca volvulus		0.0035	0.4331	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0051	0.6692	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.4331	0.617
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin gamma chain, putative	0.002	0.216	0.2774
Loa Loa (eye worm)	tubulin alpha chain	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.002	0.216	0.2648
Loa Loa (eye worm)	BEN-1 protein	0.0051	0.6692	1
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Brugia malayi	alpha-tubulin	0.002	0.216	0.2648
Trypanosoma brucei	alpha tubulin	0.002	0.216	0.2648
Trypanosoma brucei	epsilon tubulin	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.002	0.216	0.2774
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.002	0.216	0.1961
Echinococcus granulosus	Tubulin alpha 1 chain	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Toxoplasma gondii	beta tubulin	0.0051	0.6692	0.7403
Echinococcus multilocularis	Tubulin beta 2C chain	0.0051	0.6692	1
Mycobacterium leprae	cell division protein FtsZ	0.0009	0.0528	0.5
Schistosoma mansoni	tubulin subunit beta	0.0051	0.6692	0.6692
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0839	0.0506
Toxoplasma gondii	beta-tubulin, putative	0.0051	0.6692	0.7403
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0009	0.0528	0.5
Giardia lamblia	Gamma tubulin	0.002	0.216	0.2648
Echinococcus multilocularis	beta tubulin	0.0051	0.6692	1
Leishmania major	beta tubulin	0.0051	0.6692	1
Echinococcus granulosus	tubulin subunit TubB	0.002	0.216	0.2648
Toxoplasma gondii	alpha tubulin TUBA1	0.002	0.216	0.1961
Echinococcus granulosus	beta tubulin	0.0051	0.6692	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0528	0.0171
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0051	0.6692	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0011	0.0907	0.0776
Leishmania major	beta tubulin	0.0051	0.6692	1
Brugia malayi	Tubulin alpha-2 chain	0.002	0.216	0.2648
Schistosoma mansoni	alpha tubulin	0.002	0.216	0.216
Schistosoma mansoni	tubulin subunit epsilon	0.002	0.216	0.216
Trichomonas vaginalis	tubulin alpha chain, putative	0.002	0.216	0.2774
Echinococcus multilocularis	tubulin alpha chain	0.002	0.216	0.2648
Echinococcus multilocularis	Tubulin beta 2C chain	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit alpha	0.002	0.216	0.216
Trichomonas vaginalis	tubulin, putative	0.0009	0.0528	0.0171
Plasmodium vivax	tubulin epsilon chain, putative	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin subunit TubB	0.002	0.216	0.2648
Schistosoma mansoni	tubulin subunit delta	0.0009	0.0528	0.0528
Giardia lamblia	Beta tubulin	0.0051	0.6692	1
Brugia malayi	Tubulin beta-1 chain	0.0051	0.6692	1
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Trichomonas vaginalis	tubulin beta chain, putative	0.002	0.216	0.2774
Trichomonas vaginalis	tubulin alpha chain, putative	0.0011	0.0907	0.0776
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.8854	1
Loa Loa (eye worm)	BEN-1 protein	0.0051	0.6692	1
Trypanosoma brucei	epsilon tubulin	0.002	0.216	0.2648
Echinococcus multilocularis	tubulin alpha 3 chain	0.002	0.216	0.2648
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0531	0.0005
Loa Loa (eye worm)	tubulin alpha-2 chain	0.002	0.216	0.2648
Loa Loa (eye worm)	tubulin beta chain	0.0051	0.6692	1
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Leishmania major	beta tubulin	0.0051	0.6692	1
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0009	0.0528	0.5
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0839	0.0506
Trichomonas vaginalis	tubulin epsilon chain, putative	0.002	0.216	0.2774
Echinococcus granulosus	tubulin alpha 1C chain	0.002	0.216	0.2648
Brugia malayi	tubulin alpha chain - mouse	0.002	0.216	0.2648
Loa Loa (eye worm)	tubulin gamma chain	0.002	0.216	0.2648
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0009	0.0531	0.0005
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.0819	0.0473
Echinococcus granulosus	Tubulin beta 2C chain	0.0051	0.6692	1
Giardia lamblia	Beta tubulin	0.0051	0.6692	1
Leishmania major	beta tubulin	0.0051	0.6692	1
Leishmania major	epsilon tubulin, putative	0.002	0.216	0.2648
Leishmania major	alpha tubulin	0.002	0.216	0.2648
Schistosoma mansoni	tubulin subunit alpha	0.002	0.216	0.216
Echinococcus granulosus	tubulin alpha chain	0.002	0.216	0.2648
Trypanosoma brucei	alpha tubulin	0.002	0.216	0.2648
Loa Loa (eye worm)	tubulin beta-2A chain	0.0051	0.6692	1
Schistosoma mansoni	tubulin subunit gamma	0.002	0.216	0.216
Giardia lamblia	Beta tubulin	0.0051	0.6692	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0009	0.0528	0.5
Echinococcus multilocularis	tubulin alpha chain	0.002	0.216	0.2648
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0051	0.6692	1
Plasmodium falciparum	alpha tubulin 2	0.002	0.216	0.2648
Trypanosoma brucei	beta tubulin	0.002	0.216	0.2648

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	= 50.1187 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3211315

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1888733