Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.032 | 0.0592 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.032 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2558 | 0.2501 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0866 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5281 | 0.5245 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2136 | 0.2136 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4212 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.0608 | 0.1287 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2143 | 0.2083 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0608 | 0.1188 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.0423 | 0.035 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.4212 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.5695 | 0.5695 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2373 | 0.2314 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0866 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1907 | 0.4427 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0423 | 0.0774 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.032 | 0.0546 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0135 | 0.006 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1907 | 0.4427 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0866 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.4559 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0866 | 0.0866 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0866 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.0608 | 0.1287 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.