Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.8268 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4729 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.8268 | 0.8268 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.4403 | 0.4715 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.8268 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0651 | 0.0651 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.8268 | 0.5 |
Plasmodium falciparum | zinc finger protein, putative | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0542 | 0.0635 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0062 | 0.8268 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.8268 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.8268 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.8268 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0004 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0062 | 0.8268 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.8268 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.4688 | 0.4688 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.04 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0956 | 0.04 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Onchocerca volvulus | 0.0035 | 0.4403 | 0.5 | |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.8268 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.8869 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.8268 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.8268 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.4688 | 0.5299 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0542 | 0.0635 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.8268 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0127 | 0.0127 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0542 | 0.0635 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.4688 | 0.5299 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.8268 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4403 | 0.4403 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.