Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0012 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0012 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0012 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | 0.0012 | 1 | 0.5 | |
Brugia malayi | nuclear hormone receptor | 0.0012 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0012 | 1 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0012 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0012 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0012 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0012 | 1 | 0.5 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0012 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0012 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0012 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0012 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0012 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0012 | 1 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0012 | 1 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0012 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0012 | 1 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0012 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0012 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0012 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.