TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 235.348 | Formula: C12H17N3S
H donors: 1 H acceptors: 0 LogP: 2.42 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCn1cccc/c/1=N/C(=S)NCC=C
InChi: 1S/C12H17N3S/c1-3-8-13-12(16)14-11-7-5-6-10-15(11)9-4-2/h3,5-7,10H,1,4,8-9H2,2H3,(H,13,16)/b14-11-
InChiKey: XIVACNZRYBFJFI-KAMYIIQDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Schistosoma mansoni	Thioredoxin glutathione reductase	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium hominis	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Babesia bovis	thiodoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium yoelii	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	Thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus multilocularis	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Cryptosporidium parvum	thioredoxin reductase 1	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium yoelii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma brucei gambiense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	thioredoxin glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma cruzi	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Theileria parva	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania donovani	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Toxoplasma gondii	thioredoxin reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania major	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Trypanosoma congolense	trypanothione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	MGC84926 protein, related	Get druggable targets OG5_126785	All targets in OG5_126785
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma brucei	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Leishmania braziliensis	trypanothione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium berghei	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium knowlesi	thioredoxin reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium berghei	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Neospora caninum	Glutathione reductase, related	Get druggable targets OG5_126785	All targets in OG5_126785
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Candida albicans	similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase	Get druggable targets OG5_126785	All targets in OG5_126785
Schistosoma japonicum	ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium vivax	glutathione reductase, putative	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	Get druggable targets OG5_126785	All targets in OG5_126785
Plasmodium falciparum	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785
Loa Loa (eye worm)	glutathione reductase	Get druggable targets OG5_126785	All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	521 aa	21.5 %
Plasmodium knowlesi	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	518 aa	22.0 %
Plasmodium berghei	dihydrolipoyl dehydrogenase, apicoplast, putative	Thioredoxin glutathione reductase	598 aa	538 aa	25.3 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Neospora caninum	hypothetical protein	Thioredoxin glutathione reductase	598 aa	485 aa	30.5 %
Neospora caninum	Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related	Thioredoxin glutathione reductase	598 aa	512 aa	28.3 %
Plasmodium yoelii	dihydrolipoamide dehydrogenase	Thioredoxin glutathione reductase	598 aa	537 aa	24.2 %
Neospora caninum	glutathione reductase, putative	Thioredoxin glutathione reductase	598 aa	532 aa	34.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Toxoplasma gondii	NADPH-glutathione reductase	Thioredoxin glutathione reductase	598 aa	555 aa	33.5 %
Onchocerca volvulus		Thioredoxin glutathione reductase	598 aa	533 aa	50.8 %
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	Thioredoxin glutathione reductase	598 aa	513 aa	25.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.037	0.0376
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0412	0.118
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0412	0.118
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.2805	1
Schistosoma mansoni	Smad4	0.001	0.0241	0.0241
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0412	0.118
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0671	0.1923
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0104	0.699	0.8837
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3489	0.3489
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0412	0.0418
Schistosoma mansoni	smad1 5 8 and	0.001	0.0241	0.0241
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0412	0.118
Onchocerca volvulus		0.0012	0.0412	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3489	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0412	0.0418
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0412	0.118
Loa Loa (eye worm)	Smad1	0.001	0.0241	0.0245
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0412	0.0418
Brugia malayi	glutathione reductase	0.0046	0.2805	0.2849
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Toxoplasma gondii	thioredoxin reductase	0.0046	0.2805	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0412	0.0418
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.7822	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0412	0.118
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0104	0.699	0.8837
Brugia malayi	ecdysteroid receptor	0.0012	0.0412	0.0418
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0412	0.118
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0412	0.0412
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0671	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0412	0.118
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0671	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0412	0.0418
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.3489	0.3543
Mycobacterium tuberculosis	Probable reductase	0.0104	0.699	0.8837
Schistosoma mansoni	smad1 5 8 and	0.001	0.0241	0.0241
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0412	0.5
Brugia malayi	steroid hormone receptor	0.0012	0.0412	0.0418
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0241	0.0692
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0412	0.118
Echinococcus multilocularis	smad	0.001	0.0241	0.0692
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0412	0.0418
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.3489	0.3543
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0412	0.0418
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0412	0.118
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.9848	1
Brugia malayi	MH2 domain containing protein	0.001	0.0241	0.0245
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0241	0.0692
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.9848	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0412	0.0412
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0412	0.0418
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0412	0.0412
Brugia malayi	MH2 domain containing protein	0.0144	0.9848	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0412	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0412	0.0418
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0412	0.0412
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0412	0.0418
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0241	0.0692
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3489	1
Schistosoma mansoni	smad1 5 8 and	0.001	0.0241	0.0241
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3489	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0412	0.0418
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0241	0.0245
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0412	0.0418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0412	0.0418
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0671	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0412	0.0412
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0104	0.699	0.8837
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.2805	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.2849	0.8166
Loa Loa (eye worm)	glutathione reductase	0.0046	0.2805	0.2849
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0104	0.699	0.8837
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.037	0.0376
Brugia malayi	Smad1	0.001	0.0241	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0671	0.5
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0671	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0412	0.118
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0412	0.118
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.7822	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0104	0.699	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.2805	0.2849
Plasmodium falciparum	glutathione reductase	0.0046	0.2805	1
Brugia malayi	MH1 domain containing protein	0.001	0.0241	0.0245
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0412	0.118
Leishmania major	trypanothione reductase	0.0046	0.2805	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0241	0.0245
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0412	0.0418
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0671	0.5
Echinococcus multilocularis	Smad4	0.001	0.0241	0.0692
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3489	0.3489
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0241	0.0692
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0671	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0412	0.0412
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0412	0.118
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0671	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0412	0.0412
Brugia malayi	Thioredoxin reductase	0.0046	0.2805	0.2849
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0412	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0412	0.118
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0412	0.0418
Trypanosoma brucei	trypanothione reductase	0.0046	0.2805	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0412	0.0418
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0412	0.118
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0412	0.0418
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0412	0.0418
Schistosoma mansoni	coup transcription factor	0.0012	0.0412	0.0412
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0671	0.0671
Brugia malayi	nuclear hormone receptor	0.0012	0.0412	0.0418
Brugia malayi	MH2 domain containing protein	0.001	0.0241	0.0245
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0412	0.0412
Echinococcus granulosus	smad	0.001	0.0241	0.0692
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0412	0.0412
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0671	0.1923
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0671	0.0681
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0412	0.0412
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.7822	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0241	0.0241
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0412	0.0418
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0412	0.0412
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0412	0.118
Plasmodium falciparum	thioredoxin reductase	0.0046	0.2805	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.2805	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0671	0.5
Echinococcus granulosus	Smad4	0.001	0.0241	0.0692
Treponema pallidum	NADH oxidase	0.0016	0.0671	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.7822	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0412	0.0418
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.2805	0.2985
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0412	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0412	0.0418
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3489	0.3489
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0412	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0412	0.0418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0412	0.0418
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0412	0.0418
Brugia malayi	MH1 domain containing protein	0.001	0.0241	0.0245
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.2849	0.8166
Schistosoma mansoni	smad	0.001	0.0241	0.0241
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3489	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0412	0.118

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 7.9433 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3210078

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1890248