Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | flap structure-specific endonuclease 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Trypanosoma brucei | exonuclease, putative | flap structure-specific endonuclease 1 | 380 aa | 322 aa | 24.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | flap endonuclease 1, putative | 0.0031 | 0.1264 | 1 |
Echinococcus granulosus | flap endonuclease 1 | 0.0031 | 0.1264 | 0.1264 |
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3536 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3536 | 0.3536 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3536 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3536 | 0.3536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3536 | 0.3536 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3536 | 0.3536 |
Brugia malayi | Flap endonuclease-1 | 0.0031 | 0.1264 | 0.3574 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0031 | 0.1264 | 0.3574 |
Entamoeba histolytica | Flap nuclease, putative | 0.0031 | 0.1264 | 1 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0031 | 0.1264 | 1 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0031 | 0.1264 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.1264 | 1 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0031 | 0.1264 | 0.1264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3536 | 0.3536 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.1264 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3536 | 0.3536 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0031 | 0.1264 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3536 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3536 | 1 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0031 | 0.1264 | 1 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.1264 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3536 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3536 | 1 |
Schistosoma mansoni | flap endonuclease-1 | 0.0028 | 0.1112 | 0.1112 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3536 | 0.3536 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 0.5805 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 100 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.