Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxypeptidase A2 precursor | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.737 | 0.8472 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.0641 | 0.0635 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0068 | 0.0641 | 0.0709 |
Onchocerca volvulus | Cytosolic carboxypeptidase 1 homolog | 0.0084 | 0.0966 | 0.0577 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0068 | 0.0641 | 0.0635 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | 0.0084 | 0.0966 | 0.0997 | |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0084 | 0.0966 | 0.1068 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Brugia malayi | Pre-SET motif family protein | 0.0471 | 0.87 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.4584 | 0.5269 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0189 | 0.3069 | 0.3393 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0328 | 0.0377 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0488 | 0.9045 | 0.9004 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Echinococcus granulosus | geminin | 0.0376 | 0.6804 | 0.7503 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0189 | 0.3069 | 0.334 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.0641 | 0.6368 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0413 | 0.0457 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0966 | 0.1068 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Trichomonas vaginalis | set domain proteins, putative | 0.0536 | 1 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0189 | 0.3069 | 0.334 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0084 | 0.0966 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.0737 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0592 | 0.0579 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.0641 | 0.0737 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3069 | 0.3393 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0672 | 0.0772 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0068 | 0.0641 | 0.0635 |
Echinococcus multilocularis | geminin | 0.0376 | 0.6804 | 0.7503 |
Toxoplasma gondii | flagellar/basal body protein | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.4584 | 0.5269 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.4584 | 0.5269 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0413 | 0.0475 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0072 | 0.0079 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0328 | 0.0377 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0413 | 0.0457 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Plasmodium vivax | hypothetical protein, conserved | 0.0084 | 0.0966 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Onchocerca volvulus | 0.0068 | 0.0641 | 0.0238 | |
Onchocerca volvulus | 0.0102 | 0.1325 | 0.0951 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0328 | 0.0377 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0488 | 0.9045 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0471 | 0.87 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Brugia malayi | hypothetical protein | 0.0189 | 0.3069 | 0.3527 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0328 | 0.0377 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.