Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0189 | 0.3069 | 0.334 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | geminin | 0.0376 | 0.6804 | 0.7503 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0488 | 0.9045 | 0.9004 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0328 | 0.0377 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0189 | 0.3069 | 0.3393 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.4584 | 0.5269 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0471 | 0.87 | 1 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0084 | 0.0966 | 0.1068 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Echinococcus multilocularis | 0.0084 | 0.0966 | 0.0997 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | Cytosolic carboxypeptidase 1 homolog | 0.0084 | 0.0966 | 0.0577 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0068 | 0.0641 | 0.0635 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0068 | 0.0641 | 0.0709 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.0641 | 0.0635 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.737 | 0.8472 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.0641 | 0.0737 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0592 | 0.0579 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.0737 |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0084 | 0.0966 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0189 | 0.3069 | 0.334 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Trichomonas vaginalis | set domain proteins, putative | 0.0536 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0966 | 0.1068 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0413 | 0.0457 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.0641 | 0.6368 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0328 | 0.0377 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0072 | 0.0079 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0413 | 0.0475 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.4584 | 0.5269 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.4584 | 0.5269 |
Toxoplasma gondii | flagellar/basal body protein | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Echinococcus multilocularis | geminin | 0.0376 | 0.6804 | 0.7503 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0068 | 0.0641 | 0.0635 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3069 | 0.3393 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0328 | 0.0377 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | hypothetical protein | 0.0189 | 0.3069 | 0.3527 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0471 | 0.87 | 1 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0488 | 0.9045 | 1 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0084 | 0.0966 | 0.0997 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | 0.0102 | 0.1325 | 0.0951 | |
Onchocerca volvulus | 0.0068 | 0.0641 | 0.0238 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0328 | 0.0377 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Plasmodium vivax | hypothetical protein, conserved | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0413 | 0.0457 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.