Detailed information for compound 1891142

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 478.439 | Formula: C14H15N8NaO6S2
  • H donors: 3 H acceptors: 10 LogP: -1.82 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCS(=O)(=O)CC(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)[O-])CNc1nnnn1C.[Na+]
  • InChi: 1S/C14H16N8O6S2.Na/c1-21-14(18-19-20-21)16-4-7-5-29-12-9(11(24)22(12)10(7)13(25)26)17-8(23)6-30(27,28)3-2-15;/h9,12H,3-6H2,1H3,(H,17,23)(H,25,26)(H,16,18,20);/q;+1/p-1/t9-,12-;/m1./s1
  • InChiKey: DDALZNWVWXDUAZ-WYUVZMMLSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0064 0.0003
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0578 0.052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0578 0.052
Onchocerca volvulus 0.005 0.1048 1
Schistosoma mansoni lamin 0.0025 0.0342 0.0282
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0578 0.052
Loa Loa (eye worm) hypothetical protein 0.0034 0.0591 0.0591
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0064 0.0003
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0218 0.0218
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.1045 1
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0064 0.0082
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0578 0.052
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0119 0.0151
Brugia malayi RNA, U transporter 1 0.0096 0.2375 0.3008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0342 0.0342
Schistosoma mansoni coup transcription factor 0.0034 0.0578 0.052
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0119 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1421 0.1368
Plasmodium falciparum importin beta, putative 0.0034 0.058 0.5114
Brugia malayi nuclear receptor RXR 0.0018 0.0119 0.0151
Brugia malayi MH2 domain containing protein 0.013 0.3353 0.4248
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0578 0.5224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0578 0.052
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0064 0.0003
Loa Loa (eye worm) hypothetical protein 0.0245 0.6674 0.6674
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0322 0.087
Schistosoma mansoni nuclear receptor 0.0016 0.0064 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0578 0.0732
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.1094 0.1094
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0218 0.0157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0578 0.052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0578 0.052
Brugia malayi nuclear hormone receptor 0.0016 0.0064 0.0082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0064 0.0082
Brugia malayi acetyltransferase, GNAT family protein 0.0169 0.45 0.57
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0322 0.148
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0322 0.1266
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0119 0.0151
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1421 0.1567
Echinococcus multilocularis lamin dm0 0.0025 0.0342 0.0282
Loa Loa (eye worm) TAR-binding protein 0.0268 0.7342 0.7342
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0578 0.052
Brugia malayi TAR-binding protein 0.0268 0.7342 0.9299
Brugia malayi glutaminase DH11.1 0.0287 0.7895 1
Echinococcus multilocularis lamin 0.0025 0.0342 0.0282
Brugia malayi Importin beta-1 subunit 0.0034 0.058 0.0734
Brugia malayi steroid hormone receptor 0.0034 0.0578 0.0732
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.1045 0.6877
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0064 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0064 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0578 0.052
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0064 0.0064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0268 0.7342 0.7342
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1421 0.1567
Brugia malayi hypothetical protein 0.0016 0.0064 0.0082
Plasmodium vivax importin-beta 2, putative 0.0034 0.058 0.4373
Loa Loa (eye worm) hypothetical protein 0.005 0.1046 0.1046
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1094 0.1039
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0578 0.0732
Brugia malayi hypothetical protein 0.0016 0.0064 0.0082
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0814 0.0757
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0578 0.0732
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1046 0.1325
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0119 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.1421 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.1421 0.1368
Loa Loa (eye worm) RNA binding protein 0.0268 0.7342 0.7342
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Echinococcus granulosus lamin dm0 0.0025 0.0342 0.0282
Mycobacterium ulcerans glutaminase 0.0287 0.7895 1
Brugia malayi nuclear hormone receptor 0.0034 0.0578 0.0732
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0578 0.052
Onchocerca volvulus 0.0034 0.0578 0.5224
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0064 0.0003
Echinococcus granulosus intermediate filament protein 0.0025 0.0342 0.0282
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0578 0.052
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0322 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0578 0.0732
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0578 0.052
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0578 0.0578
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0578 0.052
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0218 0.0276
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0062 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0578 0.0732
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0578 0.5224
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0064 0.0003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0578 0.0578
Entamoeba histolytica hypothetical protein 0.0042 0.0814 0.843
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1094 0.1039
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0395 0.0231
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1094 0.1039
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0578 0.052
Schistosoma mansoni ran 0.0025 0.0322 0.0262
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.036 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1094 0.1039
Brugia malayi hypothetical protein 0.0018 0.0119 0.0151
Schistosoma mansoni hypothetical protein 0.005 0.1048 0.0992
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.1421 0.1368
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0578 0.052
Trichomonas vaginalis ran, putative 0.0025 0.0322 0.0136
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0322 0.2894
Entamoeba histolytica hypothetical protein 0.0042 0.0814 0.843
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0064 0.0003
Echinococcus granulosus tar DNA binding protein 0.0268 0.7342 0.7325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0062 0.0062
Brugia malayi hypothetical protein 0.0245 0.6674 0.8454
Schistosoma mansoni ap endonuclease 0.0021 0.0218 0.0157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Brugia malayi nuclear receptor NHR-88 0.0016 0.0064 0.0082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0578 0.0732
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Brugia malayi RNA binding protein 0.0268 0.7342 0.9299
Schistosoma mansoni lamin 0.0025 0.0342 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0578 0.0578
Schistosoma mansoni tar DNA-binding protein 0.0268 0.7342 0.7325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0578 0.0732
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.3353 0.3353
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1046 0.1046
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0322 0.5895
Schistosoma mansoni hypothetical protein 0.0187 0.5001 0.497
Brugia malayi nuclear receptor NHR-67 0.0016 0.0064 0.0082
Onchocerca volvulus 0.0025 0.0342 0.2818
Schistosoma mansoni zinc finger protein 0.0016 0.0064 0.0003
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0119 0.0058
Entamoeba histolytica hypothetical protein 0.0027 0.0395 0.2511
Loa Loa (eye worm) acetyltransferase 0.0169 0.45 0.45
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.058 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0395 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0578 0.052
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0064 0.0082
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.1045 0.1078
Schistosoma mansoni survival motor neuron protein 0.005 0.1048 0.0992
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0591 0.0748
Schistosoma mansoni ran 0.0025 0.0322 0.0262
Schistosoma mansoni tar DNA-binding protein 0.0268 0.7342 0.7325
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0169 0.45 0.4466
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0064 0.0003
Schistosoma mansoni ap endonuclease 0.0021 0.0218 0.0157
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0064 0.0003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0578 0.052
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0064 0.0003
Schistosoma mansoni intermediate filament proteins 0.0025 0.0342 0.0282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0578 0.0578
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0578 0.052
Schistosoma mansoni tar DNA-binding protein 0.0268 0.7342 0.7325
Brugia malayi tailless protein 0.0016 0.0064 0.0082
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0064 0.0003
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0322 0.0262
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Schistosoma mansoni hypothetical protein 0.036 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0322 0.0322
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0925 1
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0578 0.052
Echinococcus multilocularis tar DNA binding protein 0.0268 0.7342 0.7325
Echinococcus multilocularis geminin 0.0187 0.5001 0.497
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0578 0.0732
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.6674 0.6653
Loa Loa (eye worm) hypothetical protein 0.0025 0.0342 0.0342
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0578 0.0732
Brugia malayi hypothetical protein 0.0018 0.0119 0.0151
Loa Loa (eye worm) glutaminase 2 0.0287 0.7895 0.7895
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0925 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0322 0.148
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.1094 0.1386
Brugia malayi RNA recognition motif domain containing protein 0.0268 0.7342 0.9299
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0342 0.0433
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0064 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0578 0.0578
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0578 0.052
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0578 0.052
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0064 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0578 0.0732
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0578 0.052
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0814 0.0757
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0578 0.0732
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0169 0.45 0.4466
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.3353 0.3353
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Brugia malayi ecdysteroid receptor 0.0034 0.0578 0.0732
Schistosoma mansoni hypothetical protein 0.0187 0.5001 0.497
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0578 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0578 0.0732
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0042 0.0814 0.0757
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.1045 0.099
Brugia malayi hypothetical protein 0.0042 0.0814 0.1031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0578 0.052
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0064 0.0064
Echinococcus multilocularis musashi 0.0025 0.0342 0.0282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0322 0.5895
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0342 0.0342
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0395 0.0231
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1046 0.1325
Leishmania major GTP-binding protein, putative 0.0025 0.0322 0.087
Echinococcus multilocularis snurportin 1 0.036 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0578 0.0578
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0395 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0578 0.052
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0062 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0578 0.5224
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1048 0.1327
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.1421 0.1567
Entamoeba histolytica hypothetical protein 0.0042 0.0814 0.843
Brugia malayi conserved hypotetical protein 0.0016 0.0064 0.0082
Trichomonas vaginalis glutaminase, putative 0.0287 0.7895 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0218 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0578 0.0732
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0064 0.0003
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0064 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.1094 0.1039
Echinococcus granulosus geminin 0.0187 0.5001 0.497
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.058 1
Brugia malayi ecdysone receptor 0.0016 0.0064 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0578 0.052
Entamoeba histolytica hypothetical protein 0.0042 0.0814 0.843
Loa Loa (eye worm) hypothetical protein 0.0025 0.0328 0.0328
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.1045 0.1078
Leishmania major importin beta-1 subunit, putative 0.0027 0.0395 0.1476
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0064 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0578 0.0732
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0064 0.0082
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0034 0.0578 0.052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0119 0.0058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.4363 0.4328
Loa Loa (eye worm) hypothetical protein 0.0034 0.058 0.058
Schistosoma mansoni nuclear receptor 0.0016 0.0064 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.1421 0.1368
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0064 0.0082
Brugia malayi intermediate filament protein 0.0025 0.0342 0.0433
Schistosoma mansoni importin beta-1 0.0034 0.058 0.0521
Brugia malayi nuclear receptor NHR-88 0.0034 0.0578 0.0732
Echinococcus multilocularis importin subunit beta 1 0.0034 0.058 0.0521
Schistosoma mansoni glutaminase 0.0287 0.7895 0.7882
Schistosoma mansoni tar DNA-binding protein 0.0268 0.7342 0.7325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.1094 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0578 0.0732
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.1421 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0578 0.052
Onchocerca volvulus 0.0025 0.0342 0.2818
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0322 0.0262
Echinococcus granulosus importin subunit beta 1 0.0034 0.058 0.0521
Schistosoma mansoni tar DNA-binding protein 0.0268 0.7342 0.7325
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.058 0.3007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0578 0.0732
Loa Loa (eye worm) DR-78 0.0016 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0578 0.052
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0218 0.0157
Schistosoma mansoni retinoic acid receptor RXR 0.0034 0.0578 0.052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0064 0.0064
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.6674 0.6653
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0578 0.052
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.1421 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0578 0.0578
Brugia malayi nuclear receptor RXR 0.0016 0.0064 0.0082
Entamoeba histolytica Ran family GTPase 0.0025 0.0322 0.148
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0119 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.1094 0.1039
Schistosoma mansoni hypothetical protein 0.0034 0.0591 0.0532
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0814 0.0757
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0064 0.0003
Echinococcus granulosus lamin 0.0025 0.0342 0.0282
Loa Loa (eye worm) glutaminase 0.0287 0.7895 0.7895
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0925 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.1045 0.6877
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0218 0.5

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 1.6 ug ml-1 Antibacterial activity against Escherichia coli 12140 after overnight incubation by twofold agar dilution method ChEMBL. 319233

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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