Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | Immunoglobulin epsilon Fc receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Mycobacterium tuberculosis | Mce-family protein Mce2C | Immunoglobulin epsilon Fc receptor | 321 aa | 283 aa | 21.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0064 | 0.095 | 1 | |
Entamoeba histolytica | type A flavoprotein, putative | 0.012 | 0.2992 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0064 | 0.095 | 0.095 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0761 | 0.8016 |
Chlamydia trachomatis | sulfite reductase | 0.0194 | 0.5659 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.2111 | 0.1283 |
Entamoeba histolytica | type A flavoprotein, putative | 0.012 | 0.2992 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0314 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0194 | 0.5659 | 0.5203 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0314 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0278 | 0.871 | 0.8159 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0314 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0194 | 0.5659 | 0.5301 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0314 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0064 | 0.095 | 0.095 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0761 | 0.8016 |
Entamoeba histolytica | type A flavoprotein, putative | 0.012 | 0.2992 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.095 | 0.0204 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0314 | 1 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0064 | 0.095 | 0.095 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0314 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0314 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0314 | 1 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0156 | 0.4282 | 0.4282 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0314 | 1 | 1 |
Treponema pallidum | flavodoxin | 0.012 | 0.2992 | 1 |
Leishmania major | p450 reductase, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0064 | 0.095 | 0.0204 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0156 | 0.4282 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0314 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0952 | 0.0952 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0278 | 0.871 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0314 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0278 | 0.871 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.0179 | 0.5132 | 0.5132 |
Echinococcus granulosus | methionine synthase reductase | 0.0194 | 0.5659 | 0.5203 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0194 | 0.5659 | 0.5659 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.095 | 0.0204 |
Brugia malayi | flavodoxin family protein | 0.012 | 0.2992 | 0.2992 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.095 | 0.0204 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0156 | 0.4282 | 0.5 |
Loa Loa (eye worm) | flavodoxin family protein | 0.012 | 0.2992 | 0.2414 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0278 | 0.871 | 0.8159 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0314 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.012 | 0.2992 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.012 | 0.2992 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0314 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0314 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0278 | 0.871 | 0.8159 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0314 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.2111 | 0.1283 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0064 | 0.095 | 0.0204 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0158 | 0.4368 | 0.4368 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0064 | 0.095 | 0.0204 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0314 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0194 | 0.5659 | 0.5659 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0952 | 0.0206 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells | ChEMBL. | 9871623 |
IC50 (binding) | = 16 nM | Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells | ChEMBL. | 9871623 |
IC50 (binding) | <= 100 nM | Inhibitory activity of the compound towards human recombinant fibroblast collagenase | ChEMBL. | 9871623 |
IC50 (binding) | <= 100 nM | Inhibitory activity of the compound towards human recombinant fibroblast collagenase | ChEMBL. | 9871623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.