Detailed information for compound 1891554

Basic information

Technical information
  • TDR Targets ID: 1891554
  • Name: 1-acetyl-3-chloro-5,5-bis(4-chlorophenyl)imid azolidine-2,4-dione
  • MW: 397.64 | Formula: C17H11Cl3N2O3
  • H donors: 0 H acceptors: 3 LogP: 4.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1(c2ccc(cc2)Cl)N(C(=O)C)C(=O)N(C1=O)Cl
  • InChi: 1S/C17H11Cl3N2O3/c1-10(23)21-16(25)22(20)15(24)17(21,11-2-6-13(18)7-3-11)12-4-8-14(19)9-5-12/h2-9H,1H3
  • InChiKey: KUGHXCWFPQFOKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-acetyl-3-chloro-5,5-bis(4-chlorophenyl)hydantoin
  • 3-chloro-5,5-bis(4-chlorophenyl)-1-ethanoyl-imidazolidine-2,4-dione
  • 62031-91-8
  • 2,4-Imidazolidinedione, 1-acetyl-3-chloro-5,5-bis(4-chlorophenyl)-
  • NSC169807

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.2686 0.7583
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0418 0.0418
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0418 0.118
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0418 0.118
Brugia malayi MH1 domain containing protein 0.0009 0.0245 0.0245
Loa Loa (eye worm) Smad1 0.0009 0.0245 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0418 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0418 0.0418
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0245 0.0692
Entamoeba histolytica hypothetical protein 0.004 0.2686 0.5
Echinococcus multilocularis Smad4 0.0009 0.0245 0.0692
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0418 0.118
Loa Loa (eye worm) transcription factor SMAD2 0.0132 1 1
Entamoeba histolytica hypothetical protein 0.004 0.2686 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0418 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0418 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.3543 1
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0418 0.118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0418 0.0418
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0418 0.118
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0418 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3543 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0418 0.118
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.3543 0.3543
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0418 0.118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Schistosoma mansoni smad1 5 8 and 0.0009 0.0245 0.0692
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0418 0.118
Schistosoma mansoni smad1 5 8 and 0.0009 0.0245 0.0692
Brugia malayi Smad1 0.0009 0.0245 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0418 0.0418
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0418 0.118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0418 0.118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3543 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.3543 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0418 0.0418
Brugia malayi steroid hormone receptor 0.0011 0.0418 0.0418
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0418 0.0418
Schistosoma mansoni smad1 5 8 and 0.0009 0.0245 0.0692
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0418 0.118
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0418 0.118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Entamoeba histolytica hypothetical protein 0.004 0.2686 0.5
Entamoeba histolytica hypothetical protein 0.004 0.2686 0.5
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0418 0.118
Schistosoma mansoni coup transcription factor 0.0011 0.0418 0.118
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0418 0.118
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0418 0.0418
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0418 0.118
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0245 0.0245
Onchocerca volvulus 0.0011 0.0418 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0418 0.0418
Schistosoma mansoni hypothetical protein 0.004 0.2686 0.7583
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.3543 1
Brugia malayi hypothetical protein 0.004 0.2686 0.2686
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0418 0.118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0418 0.0418
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0418 0.0418
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0418 0.0418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0418 0.118
Brugia malayi nuclear hormone receptor 0.0011 0.0418 0.0418
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0418 0.118
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.3543 1
Brugia malayi MH2 domain containing protein 0.0009 0.0245 0.0245
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0245 0.0692
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0418 0.0418
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0011 0.0418 0.0418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.3543 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.3543 0.3543
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0418 0.118
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0418 0.118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0418 0.0418
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0418 0.118
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0418 0.118
Echinococcus multilocularis smad 0.0009 0.0245 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0418 0.0418
Brugia malayi nuclear receptor NHR-88 0.0011 0.0418 0.0418
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0418 0.5
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0245 0.0692
Echinococcus granulosus Smad4 0.0009 0.0245 0.0692
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0418 0.118
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0245 0.0692
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0418 0.118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0418 0.0418
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0418 0.0418
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.2686 0.7583
Brugia malayi ecdysteroid receptor 0.0011 0.0418 0.0418
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0418 0.118
Schistosoma mansoni Smad4 0.0009 0.0245 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0418 0.0418
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0418 0.118
Brugia malayi MH2 domain containing protein 0.0009 0.0245 0.0245
Brugia malayi MH1 domain containing protein 0.0009 0.0245 0.0245
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0245 0.0692
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0418 0.118
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0418 0.0418
Schistosoma mansoni smad 0.0009 0.0245 0.0692
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0418 0.118
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0418 0.118
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0245 0.0245
Schistosoma mansoni transcription factor LCR-F1 0.004 0.2686 0.7583
Echinococcus granulosus smad 0.0009 0.0245 0.0692
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0418 0.118

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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