Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.0672 | 0.0669 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | geminin | 0.0376 | 0.6804 | 0.7503 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0065 | 0.0592 | 0.0579 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Onchocerca volvulus | Cytosolic carboxypeptidase 1 homolog | 0.0084 | 0.0966 | 0.0577 |
Echinococcus granulosus | cytosolic carboxypeptidase 1 | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | Pre-SET motif family protein | 0.0068 | 0.0641 | 0.0737 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | Carboxypeptidase A2 precursor | 0.0084 | 0.0966 | 0.111 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Onchocerca volvulus | 0.0068 | 0.0641 | 0.0238 | |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0176 | 0.2807 | 0.3227 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.0672 | 0.0772 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0471 | 0.87 | 1 |
Echinococcus multilocularis | 0.0084 | 0.0966 | 0.0997 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0189 | 0.3069 | 0.3393 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0405 | 0.737 | 0.8472 |
Schistosoma mansoni | hypothetical protein | 0.0084 | 0.0966 | 0.1068 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0265 | 0.4584 | 0.5269 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Echinococcus granulosus | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0084 | 0.0966 | 0.0577 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0328 | 0.0377 |
Brugia malayi | MH2 domain containing protein | 0.0265 | 0.4584 | 0.5269 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0068 | 0.0641 | 0.0635 |
Trichomonas vaginalis | set domain proteins, putative | 0.0536 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0413 | 0.0475 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0068 | 0.0641 | 0.0635 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0068 | 0.0641 | 0.0709 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0488 | 0.9045 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0275 | 0.4788 | 0.5257 |
Echinococcus granulosus | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0328 | 0.0377 |
Echinococcus multilocularis | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.0997 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0068 | 0.0641 | 0.0635 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.0084 | 0.0966 | 1 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Schistosoma mansoni | protease m14 carboxypeptidase | 0.0084 | 0.0966 | 0.1068 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.0672 | 0.0772 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Toxoplasma gondii | flagellar/basal body protein | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0641 | 0.0737 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.0084 | 0.0966 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.3069 | 0.3393 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0328 | 0.0377 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0072 | 0.0079 |
Echinococcus granulosus | geminin | 0.0376 | 0.6804 | 0.7503 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0488 | 0.9045 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | 0.0084 | 0.0966 | 0.0577 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0189 | 0.3069 | 0.334 |
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0265 | 0.4584 | 0.5269 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Echinococcus multilocularis | cytosolic carboxypeptidase protein 5 | 0.0084 | 0.0966 | 0.0997 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0068 | 0.0641 | 0.6368 |
Brugia malayi | Pre-SET motif family protein | 0.0471 | 0.87 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.0084 | 0.0966 | 0.5 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0413 | 0.0457 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | carboxypeptidase N (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Brugia malayi | hypothetical protein | 0.0275 | 0.4788 | 0.5504 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.6804 | 0.7523 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.0672 | 0.0772 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0072 | 0.0083 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0176 | 0.2807 | 0.3048 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0084 | 0.0966 | 0.111 |
Onchocerca volvulus | 0.0102 | 0.1325 | 0.0951 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Onchocerca volvulus | 0.0488 | 0.9045 | 0.9004 | |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Brugia malayi | hypothetical protein | 0.0189 | 0.3069 | 0.3527 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0189 | 0.3069 | 0.334 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.0672 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Schistosoma mansoni | metallocarboxypeptidase D peptidase unit 2 (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0966 | 0.111 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.3069 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0328 | 0.0377 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0488 | 0.9045 | 0.9004 |
Plasmodium vivax | hypothetical protein, conserved | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0068 | 0.0641 | 0.0709 |
Schistosoma mansoni | peptidase | 0.0084 | 0.0966 | 0.1068 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0413 | 0.0457 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | family M14 non-peptidase homologue (M14 family) | 0.0084 | 0.0966 | 0.1068 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.0084 | 0.0966 | 1 |
Trichomonas vaginalis | Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase | 0.0084 | 0.0966 | 0.0901 |
Schistosoma mansoni | alpha-glucosidase | 0.0152 | 0.2318 | 0.2562 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.0672 | 0.0772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.