Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0163 | 0.1874 | 0.4423 |
Brugia malayi | hypoxia-induced factor 1 | 0.0171 | 0.1988 | 0.6313 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.3148 | 0.3148 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0604 | 0.192 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.3169 | 0.7478 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.0366 | 0.028 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Trichomonas vaginalis | dexras1, putative | 0.0065 | 0.0604 | 0.0639 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Echinococcus granulosus | single minded 2 | 0.0041 | 0.0286 | 0.0286 |
Echinococcus granulosus | dna polymerase kappa | 0.0047 | 0.0366 | 0.0366 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.0321 | 0.0321 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0161 | 0.1851 | 0.4368 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0034 | 0.0195 | 0.0195 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0181 | 0.2114 | 0.6715 |
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.3148 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0043 | 0.0313 | 0.0995 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0043 | 0.0313 | 0.0988 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.3148 | 0.3148 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0217 | 0.0689 |
Toxoplasma gondii | thioredoxin reductase | 0.0043 | 0.0313 | 0.0988 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.3169 | 0.7478 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0098 | 0.1033 | 0.3281 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1632 | 0.5182 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.052 | 0.1227 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0195 | 0.0619 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0019 | 0 | 0.0001 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0024 | 0.0067 | 0.0212 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0786 | 1 | 1 |
Brugia malayi | Ras protein let-60 | 0.0065 | 0.0604 | 0.192 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0537 | 0.1705 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0161 | 0.1851 | 0.4368 |
Plasmodium falciparum | topoisomerase I | 0.0215 | 0.2555 | 0.8064 |
Plasmodium vivax | SET domain protein, putative | 0.0034 | 0.0195 | 0.0614 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0109 | 0.1176 | 0.0676 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0109 | 0.1176 | 0.3735 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.3169 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.0557 | 0.1767 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0215 | 0.2555 | 0.8116 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0215 | 0.2555 | 0.2555 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0537 | 0.1705 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.1632 | 0.5182 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0333 | 0.4092 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.0217 | 0.0511 |
Onchocerca volvulus | 0.013 | 0.1444 | 0.4061 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0024 | 0.0067 | 0.0157 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.1444 | 0.4044 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0098 | 0.1033 | 0.3281 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0786 | 1 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.0215 | 0.2555 | 0.8064 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.0366 | 0.0864 |
Brugia malayi | glutathione reductase | 0.0043 | 0.0313 | 0.0995 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.3148 | 1 |
Leishmania major | trypanothione reductase | 0.0043 | 0.0313 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0537 | 0.1705 |
Brugia malayi | bHLH-PAS transcription factor | 0.0041 | 0.0286 | 0.0909 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0062 | 0.0557 | 0.051 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0033 | 0.0179 | 0.0179 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0537 | 0.1705 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0382 | 0.0901 |
Echinococcus granulosus | ras gtpase | 0.0065 | 0.0604 | 0.0604 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0054 | 0.0456 | 0.1076 |
Trichomonas vaginalis | rap1 and, putative | 0.0065 | 0.0604 | 0.0639 |
Trichomonas vaginalis | rheb, putative | 0.0065 | 0.0604 | 0.0639 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0237 | 0.2842 | 0.9028 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0195 | 0.0195 |
Onchocerca volvulus | 0.0041 | 0.0286 | 0.0297 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0034 | 0.0195 | 0.0195 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0382 | 0.0901 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0195 | 0.0195 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0163 | 0.1872 | 0.554 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0034 | 0.0195 | 0.0614 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0055 | 0.0474 | 0.0474 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.0321 | 0.0321 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0065 | 0.0604 | 0.0639 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0054 | 0.0456 | 0.1076 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0043 | 0.0313 | 0.0739 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.3148 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.0557 | 0.1768 |
Echinococcus multilocularis | ras gtpase | 0.0065 | 0.0604 | 0.0604 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.2175 | 0.691 |
Loa Loa (eye worm) | glutathione reductase | 0.0043 | 0.0313 | 0.0995 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0163 | 0.1872 | 0.3966 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.3148 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0024 | 0.0067 | 0.0157 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0163 | 0.1874 | 0.4423 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0382 | 0.0901 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0109 | 0.1176 | 0.3735 |
Trichomonas vaginalis | set domain proteins, putative | 0.027 | 0.3269 | 0.7792 |
Brugia malayi | hypothetical protein | 0.0186 | 0.2175 | 0.691 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.1444 | 0.4585 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.1444 | 0.1444 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0098 | 0.1033 | 0.3281 |
Brugia malayi | Isocitrate dehydrogenase | 0.0019 | 0 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0288 | 0.0288 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.1632 | 0.5182 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0034 | 0.0195 | 0.0195 |
Brugia malayi | DNA topoisomerase I | 0.0215 | 0.2555 | 0.8116 |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.3148 | 0.3148 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.1444 | 0.4585 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0065 | 0.0604 | 0.0639 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0036 | 0.0217 | 0.0511 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0215 | 0.2555 | 0.8064 |
Plasmodium vivax | glutathione reductase, putative | 0.0043 | 0.0313 | 0.0988 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0041 | 0.0286 | 0.0286 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0288 | 0.0916 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0034 | 0.0195 | 0.0195 |
Mycobacterium ulcerans | hypothetical protein | 0.0181 | 0.2114 | 0.6387 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0344 | 0.4237 | 1 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0171 | 0.1988 | 0.6313 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0047 | 0.0366 | 0.028 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0215 | 0.2555 | 0.2555 |
Brugia malayi | Pre-SET motif family protein | 0.0237 | 0.2842 | 0.9028 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0163 | 0.1872 | 0.5945 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0163 | 0.1874 | 0.4423 |
Trypanosoma brucei | unspecified product | 0.004 | 0.0268 | 0.0631 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.1444 | 0.1941 |
Brugia malayi | Thioredoxin reductase | 0.0043 | 0.0313 | 0.0995 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0048 | 0.0382 | 0.0901 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.3148 | 1 |
Trichomonas vaginalis | ral, putative | 0.0065 | 0.0604 | 0.0639 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0344 | 0.4237 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0043 | 0.0313 | 0.0994 |
Mycobacterium tuberculosis | Probable reductase | 0.0098 | 0.1033 | 0.3281 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0161 | 0.1851 | 0.1851 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.3148 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 0.3169 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0043 | 0.0313 | 0.0739 |
Plasmodium falciparum | glutathione reductase | 0.0043 | 0.0313 | 0.0988 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0054 | 0.0456 | 0.1076 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0161 | 0.1851 | 0.1851 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.3169 | 0.7478 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0215 | 0.2555 | 0.2555 |
Echinococcus multilocularis | dna polymerase kappa | 0.0047 | 0.0366 | 0.0366 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0034 | 0.0195 | 0.0195 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.1444 | 0.1444 |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.3148 | 1 |
Brugia malayi | polk-prov protein | 0.0036 | 0.0217 | 0.0689 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0047 | 0.0366 | 0.0864 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 0.3169 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0098 | 0.1033 | 0.3281 |
Brugia malayi | PAS domain containing protein | 0.0055 | 0.0474 | 0.1506 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0288 | 0.0916 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0065 | 0.0604 | 0.192 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.1444 | 0.1444 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0475 | 0.1498 |
Schistosoma mansoni | single-minded | 0.0055 | 0.0474 | 0.0474 |
Onchocerca volvulus | 0.027 | 0.3269 | 1 | |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0047 | 0.0366 | 0.0864 |
Leishmania major | DNA polymerase kappa, putative | 0.0024 | 0.0067 | 0.0157 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0344 | 0.4237 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0344 | 0.4237 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0333 | 0.4092 | 1 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0065 | 0.0604 | 0.192 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0098 | 0.1033 | 0.3281 |
Brugia malayi | Pre-SET motif family protein | 0.0034 | 0.0195 | 0.0619 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0268 | 0.0631 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0062 | 0.0557 | 0.1313 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0109 | 0.1176 | 0.3735 |
Brugia malayi | thymidylate synthase | 0.013 | 0.1444 | 0.4585 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0333 | 0.4092 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0043 | 0.0313 | 0.0988 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0161 | 0.1851 | 0.4368 |
Brugia malayi | isocitrate dehydrogenase | 0.0019 | 0 | 0.0001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MCD (functional) | = 80 mg kg-1 | Antimalarial activity against trophozoite-induced Plasmodium berghei infected in sc dosed mouse assessed as minimum curative dose | ChEMBL. | 117107 |
MIC (functional) | > 25 ug ml-1 | Antibacterial activity against Escherichia coli Vogel assessed as growth inhibition | ChEMBL. | 117107 |
MIC (functional) | > 25 ug ml-1 | Antibacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition | ChEMBL. | 117107 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.