Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus genotype 1a (isolate 1) (HCV) | Hepatitis C virus polyprotein | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_130943 | All targets in OG5_130943 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | Get druggable targets OG5_130943 | All targets in OG5_130943 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | Get druggable targets OG5_130943 | All targets in OG5_130943 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.0094 | 0 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.0094 | 0 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.029 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.029 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.029 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.029 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.029 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Plasmodium falciparum | adenosine deaminase | 0.029 | 1 | 1 |
Treponema pallidum | adenosine deaminase | 0.029 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.029 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.029 | 1 | 1 |
Entamoeba histolytica | adenosine deaminase, putative | 0.029 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.029 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Trypanosoma cruzi | AMP deaminase 2, putative | 0.0094 | 0 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.029 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.029 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.029 | 1 | 1 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.0094 | 0 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0195 | 0.5169 | 0.5169 |
Trypanosoma brucei | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.0094 | 0 | 0.5 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.029 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 1 | 1 |
Mycobacterium ulcerans | adenosine deaminase | 0.029 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.029 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibition of Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B activity. | ChEMBL. | 12951122 |
IC50 (binding) | = 13 uM | Inhibition of Hepatitis C RNA dependent RNA polymerase Nonstructural protein 5B activity. | ChEMBL. | 12951122 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.